Targeting CD83 for the treatment of graft-versus-host disease (Review)

Wang,Xiongfei; Wei,Ming  Q.; Liu,Xiaosong

doi:10.3892/etm.2013.1033

Targeting CD83 for the treatment of graft-versus-host disease (Review)

Authors:
- Xiongfei Wang
- Ming Q. Wei
- Xiaosong Liu
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Affiliations: Division of Molecular and Gene Therapies, Griffith Health Institute and School of Medical Science, Griffith University, Gold Coast, Queensland 4222, Australia, Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, P.R. China
Published online on: April 2, 2013 https://doi.org/10.3892/etm.2013.1033
Pages: 1545-1550

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Abstract

Graft-versus-host disease (GVHD) is a common and often fatal complication of bone marrow transplantation. Antigen-presenting cells from donor and recipient play a critical role in the initiation and maintenance of GVHD. CD83, which is expressed in activated lymphocytes and dendritic cells, is regarded as a marker of mature dendritic cells. Targeting CD83 using soluble CD83 molecules or antibodies has been demonstrated to have therapeutic effects against GVHD in preclinical models. Understanding the biological function of CD83 and the underlying mechanisms through which targeting CD83 attenuates GVHD is likely to greatly improve current treatments and provide new methods for the treatment of GVHD.

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