Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis

Shi,Jing; Tong,Jianhua; Cai,Shuang; Qu,Xiujuan; Liu,Yunpeng

doi:10.3892/etm.2013.1148

Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis

Authors:
- Jing Shi
- Jianhua Tong
- Shuang Cai
- Xiujuan Qu
- Yunpeng Liu
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Affiliations: Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Drug Clinical Trials, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Pharmacy, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
Published online on: June 7, 2013 https://doi.org/10.3892/etm.2013.1148
Pages: 435-444

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Abstract

Recent investigations have suggested that common genetic polymorphisms in BRCA1‑associated C‑terminal helicase 1 (BACH1) are important in the development of breast cancer. However, individually published studies and previous meta‑analyses have demonstrated inconclusive results. The aim of this meta‑analysis was to derive a more precise estimation of the correlation between a common polymorphism [proline (Pro) 919 serine (Ser); rs4986764 C>T] in the BACH1 gene and susceptibility to breast cancer. A literature search of PubMed, Embase, Web of Science and Chinese BioMedicine (CBM) databases was conducted on articles published prior to March 1, 2013. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Eleven case‑control studies were included with a total of 6,903 breast cancer cases and 8,154 healthy controls. The meta‑analysis results revealed that the BACH1 919Ser polymorphism may be correlated with a decreased risk of breast cancer among Caucasian populations (Ser allele versus Pro allele: OR=0.90, 95% CI=0.86‑0.95; Pro/Ser + Ser/Ser versus Pro/Pro: OR=0.90, 95% CI=0.84‑0.98; Ser/Ser versus Pro/Pro + Pro/Ser: OR=0.84, 95% CI=0.76‑0.92; Ser/Ser versus Pro/Pro: OR=0.81, 95% CI=0.73‑0.91; Ser/Ser versus Pro/Ser: OR=0.86, 95% CI=0.78‑0.95), although not among Asian populations. Further subgroup analyses indicated that there were significant correlations between the BACH1 919Ser polymorphism and a decreased risk of breast cancer in postmenopausal females, females with a family history of breast cancer and females without BRCA1/2 mutations. Univariate and multivariate meta‑regression analyses revealed that none of the factors explained the heterogeneity (all P>0.05). The present meta‑analysis suggested that the BACH1 919Ser polymorphism may decrease the risk of breast cancer among Caucasian populations, particularly in postmenopausal females with a family history of breast cancer and without BRCA1/2 mutations.

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