Correlation between fungal sIgE and bronchial asthma severity

Zou,Hui; Su,Lei; Fang,Qiu-Hong; Ma,Ying-Min

doi:10.3892/etm.2013.1153

Correlation between fungal sIgE and bronchial asthma severity

Authors:
- Hui Zou
- Lei Su
- Qiu-Hong Fang
- Ying-Min Ma
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Affiliations: Department of Pulmonary and Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China
Published online on: June 10, 2013 https://doi.org/10.3892/etm.2013.1153
Pages: 537-541

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Abstract

Fungal sensitisation is closely associated with asthma; however, the correlation between fungi and asthma severity remains unclear. The aim of this study was to investigate the severity of asthma in 100 patients with asthma due to fungal and non-fungal allergens. A total of 100 outpatients and inpatients with asthma were selected from 2010 to 2011 and were divided into three groups (mild, moderate and severe) according to their clinical manifestations, lung function results and treatment situations. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of specific immunoglobulin E (sIgE) to five fungal allergens and seven non-fungal allergens in the serum of all patients. The levels of sIgE to Aspergillus, Penicillium and Candida albicans allergens in the severe group were significantly higher compared with those in the moderate and mild groups (P<0.001 and P<0.05, respectively); those of the moderate group were significantly higher compared with those of the mild group (P<0.05). No significant difference was observed for the levels of sIgE to Alternaria alternata among the three groups. sIgE to Cladosporium herbarum was not present for all three groups. No significant difference was observed for the levels of sIgE to non-fungal allergens among the three groups. Fungal allergens are closely correlated with the severity of asthma, whereas non-fungal allergens are not.

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1.	Chung KF, Godard P, Adelroth E, et al: Difficult/therapy-resistant asthma. Eur Respir J. 13:1198–1208. 1999.
2.	Targonski PV, Persky VW and Ramekrishnan V: Effect of environmental molds on risk of death from asthma during the pollen season. J Allergy Clin Immunol. 95:955–961. 1995. View Article : Google Scholar : PubMed/NCBI
3.	Delfino RJ, Zeiger RS, Seltzer JM, Street DH, Matteucci RM, Anderson PR and Koutrakis P: The effect of outdoor fungal spore concentrations on daily asthma severity. Environ Health Perspect. 105:622–635. 1997. View Article : Google Scholar : PubMed/NCBI
4.	Neas LM, Dockery DW, Burge H, Koutrakis P and Speizer FE: Fungus spores, air pollutants and other determinants of peak expiratory flow rate in children. Am J Epidemiol. 143:797–807. 1996. View Article : Google Scholar
5.	Salvaggio J, Seabury J and Schoenhardt E: New Orleans Asthma. V. Relationship between Charity Hospital admission rates, semi-quantitative pollen and fungal spore counts, and total particulate aerometric sampling data. J Allergy Clin Immunol. 48:96–114. 1971. View Article : Google Scholar
6.	Newson R, Strachan D, Corden J and Millington W: Fungal and other spore counts as predictors of admissions for asthma in the Trent region. Occup Environ Med. 57:786–792. 2000. View Article : Google Scholar : PubMed/NCBI
7.	Denning DW, O’Driscoll BR, Hogaboam CM, Bowyer P and Niven RM: The link between fungi and severe asthma: a summary of the evidence. Eur Respir J. 27:615–626. 2006. View Article : Google Scholar : PubMed/NCBI
8.	Black PN, Udy AA and Brodie SM: Sensitivity to fungal allergens is a risk factor for life-threatening asthma. Allergy. 55:501–504. 2000. View Article : Google Scholar : PubMed/NCBI
9.	O’Driscoll RB, Hopkinson L and Denning DW: Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions. BMC Pulm Med. 5:42005.PubMed/NCBI
10.	Neukirch C, Henry C, Leynaert B, Liard R, Bousquet J and Neukirch F: Is sensitization to Alternaria alternata a risk factor for severe asthma? A population-based study. J Allergy Clin Immunol. 103:709–711. 1999.
11.	Zureik M, Neukirch C, Leynaert B, Liard R, Bousquet J and Neukirch F; European Community Respiratory Health Survey: Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community respiratory health survey. BMJ. 325:411–417. 2002. View Article : Google Scholar : PubMed/NCBI
12.	O’Hollaren MT, Yunginger JW, Offord KP, Somers MJ, O’Connell EJ, Ballard DJ and Sachs MI: Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med. 324:359–363. 1991.PubMed/NCBI
13.	Asthma Group of Respiratory Disease Division of Chinese Medical Association: Guidelines for the prevention and treatment of bronchial asthma. Chinese Journal of Tuberculosis and Respiratory Diseases. 31:177–185. 2008.(In Chinese).
14.	Kleyn JG, Johnson WM and Wetzler TF: Microbial aerosols and actinomycetes in etiological considerations of mushroom workers’ lungs. Appl Environ Microbiol. 41:1454–1460. 1981.PubMed/NCBI
15.	Zhai JH, Cui H, Chen ML, Xu XZ, Shun ZH, Hu QX and Sun RQ: Analysis and identification of airborne fungus in Beijing and Nanjing. China Public Health. 16:10262000.(In Chinese).
16.	Matsuoka H, Niimi A, Matsumoto H, et al: Specific IgE response to trichophyton and asthma severity. Chest. 135:898–903. 2009. View Article : Google Scholar : PubMed/NCBI
17.	Ward GW Jr, Karlsson G, Rose G and Platts-Mills TA: Trichophyton asthma: sensitization of bronchi and upper airways to dermatophyte antigen. Lancet. 1:859–862. 1989. View Article : Google Scholar : PubMed/NCBI
18.	Riding DM, Denning DW, Francis HC and Niven RM: The effect of itraconazole therapy in severe asthma patients allergic to aspergillus: a retrospective audit. In: Presented at the Advances against aspergillosis conference (abstract 75); 2004, http://www.advancesagainstaspergillosis.org/pdfs/2004syllabus.pdfuri.
19.	Ward GW Jr, Woodfolk JA, Hayden ML, Jackson S and Platts-Mills TA: Treatment of late-onset asthma with fluconazole. J Allergy Clin Immunol. 104:541–546. 1999. View Article : Google Scholar : PubMed/NCBI
20.	Denning DW, O’Driscoll BR, Powell G, et al: Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med. 179:11–18. 2009. View Article : Google Scholar : PubMed/NCBI