Astrocytoma development following complete multiple myeloma remission in a 49‑year‑old patient: A case report

Han,Xiaoyan; Jin,Dian; Zheng,Gaofeng; Luo,Yi; Cai,Zhen

doi:10.3892/etm.2013.1179

Astrocytoma development following complete multiple myeloma remission in a 49‑year‑old patient: A case report

Authors:
- Xiaoyan Han
- Dian Jin
- Gaofeng Zheng
- Yi Luo
- Zhen Cai
View Affiliations

Affiliations: Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
Published online on: June 25, 2013 https://doi.org/10.3892/etm.2013.1179
Pages: 509-512

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Multiple myeloma (MM), one of the B‑cell non‑Hodgkin lymphomas, is a bone marrow‑derived, antibody‑producing cancer of the plasma cells. In the advanced stages, the cancer cells frequently cause widespread osteolytic bone damage; however, in rare cases, MM also manifests as an intracranial plasmacytoma. In the present study, we describe a case in which a patient, initially treated for MM and with subsequent complete remission, was admitted to hospital with a lesion in the right cerebellar hemisphere and neurological symptoms of a brain tumor. Our initial diagnosis was an MM relapse with the rare occurring intracranial manifestation. However, pathological tests confirmed the diagnosis of a high‑grade astrocytoma. In this case report, we describe the characteristics, as well as the treatment issues, diagnoses and clinical developments of this patient.

View Figures

View References

1.	Dimopoulos MA and Terpos E: Multiple myeloma. Ann Oncol. 21(Suppl 7): 143–150. 2010. View Article : Google Scholar
2.	Fassas AB, Muwalla F, Berryman T, et al: Myeloma of the central nervous system: association with high-risk chromosomal abnormalities, plasmablastic morphology and extramedullary manifestations. Br J Haematol. 117:103–108. 2002. View Article : Google Scholar
3.	Schneider T, Mawrin C, Scherlach C, Skalej M and Firsching R: Gliomas in adults. Dtsch Arztebl Int. 107:799–807. 2010.PubMed/NCBI
4.	Kato I, Kinouchi H, Imaizumi S, Katakura R and Yoshimoto T: An autopsy case of cerebral astrocytoma associated with multiple myeloma. No Shinkei Geka. 17:877–881. 1989.(In Japanese).
5.	Gisserot O, de Jaureguiberry JP, Ribeil JA, Villemagne B and Jaubert D: Cerebral glioblastoma complicating the course of myeloma. Presse Med. 26:11971997.(In French).
6.	González Silva M: Second neoplasm in a patient diagnosed with IgD myeloma. Presentation of a case and review of the literature. Sangre (Barc). 38:47–49. 1993.(In Spanish).
7.	Sonoda Y, Kumabe T, Umezawa K, Shimizu H, Murakawa Y, Kanamaru R and Yoshimoto T: Rapid growth of glioblastoma during therapy for multiple myeloma: case report. No Shinkei Geka. 26:737–741. 1998.(In Japanese).
8.	Nieuwenhuizen L and Biesma DH: Central nervous system myelomatosis: review of the literature. Eur J Haematol. 80:1–9. 2008.
9.	Cerase A, Tarantino A, Gozzetti A, et al: Intracranial involvement in plasmacytomas and multiple myeloma: a pictorial essay. Neuroradiology. 50:665–674. 2008. View Article : Google Scholar : PubMed/NCBI
10.	Sathornsumetee S, Rich JN and Reardon DA: Diagnosis and treatment of high-grade astrocytoma. Neurol Clin. 25:1111–1139. 2007. View Article : Google Scholar
11.	Schluterman KO, Fassas AB, Van Hemert RL and Harik SI: Multiple myeloma invasion of the central nervous system. Arch Neurol. 61:1423–1429. 2004. View Article : Google Scholar : PubMed/NCBI
12.	Quach H, Ryan G, Ganju V and Prince HM: Effective treatment of leptomeningeal multiple myeloma with total craniospinal irradiation supported by second allogeneic donor stem cell infusion. Bone Marrow Transplant. 35:423–424. 2005. View Article : Google Scholar
13.	Gozzetti A, Cerase A, Lotti F, et al: Extramedullary intracranial localization of multiple myeloma and treatment with novel agents: a retrospective survey of 50 patients. Cancer. 118:1574–1584. 2011. View Article : Google Scholar : PubMed/NCBI
14.	Synhaeve NE, van der Heul C and Tijssen CC: Intracranial mass of multiple myeloma with good response to chemotherapy. BMJ Case Rep. 2012:2012.PubMed/NCBI
15.	Weller M: Novel diagnostic and therapeutic approaches to malignant glioma. Swiss Med Wkly. 141:w132102011.PubMed/NCBI
16.	Wainwright DA, Balyasnikova IV, Han Y and Lesniak MS: The expression of BST2 in human and experimental mouse brain tumors. Exp Mol Pathol. 91:440–446. 2011. View Article : Google Scholar : PubMed/NCBI
17.	Goto T, Kennel SJ, Abe M, Takishita M, Kosaka M, Solomon A and Saito S: A novel membrane antigen selectively expressed on terminally differentiated human B cells. Blood. 84:1922–1930. 1994.PubMed/NCBI
18.	Goswami S, Gupta A and Sharma SK: Interleukin-6-mediated autocrine growth promotion in human glioblastoma multiforme cell line U87MG. J Neurochem. 71:1837–1845. 1998. View Article : Google Scholar : PubMed/NCBI
19.	Liu Q, Li G, Li R, et al: IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines. J Neurooncol. 100:165–176. 2010. View Article : Google Scholar : PubMed/NCBI
20.	Tanabe K, Matsushima-Nishiwaki R, Yamaguchi S, Iida H, Dohi S and Kozawa O: Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells. J Neuroinflammation. 7:162010. View Article : Google Scholar : PubMed/NCBI
21.	Thomas A, Mailankody S, Korde N, Kristinsson SY, Turesson I and Landgren O: Second malignancies after multiple myeloma: from 1960s to 2010s. Blood. 119:2731–2737. 2012. View Article : Google Scholar : PubMed/NCBI