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Article

Effect of exercise training on long‑term potentiation and NMDA receptor channels in rats with cerebral infarction

  • Authors:
    • Qian Yu
    • Xiaohong Li
    • Jing Wang
    • Yufeng Li
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China, Department of Neurology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China, Department of Nutrition, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China
  • Pages: 1431-1436
    |
    Published online on: September 27, 2013
       https://doi.org/10.3892/etm.2013.1319
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Abstract

The aim of the present study was to investigate the effects of exercise training on the characteristics of long‑term potentiation (LTP) and N-methyl-D aspartate (NMDA) receptor channels in the hippocampal CA3 neurons of rats with cerebral infarction. Wistar rats were randomly allocated into the model without any training and rehabilitation with exercise training. A model of cerebral infarction was established by middle cerebral artery occlusion . Using chronically embedded electrodes combined with an electrophysiological method, the population spike (PS) amplitude and latency, as well as changes in the NMDA single channel current in the hippocampal neurons were determined prior to and following Y-maze discrimination learning 60 times in the two groups. The formation of learning‑dependent LTP and synaptic efficacy in the hippocampal CA3 area after exercise training in the rehabilitation group was significantly faster compared with that in the model group without any training (P<0.05). The incubation period of the PS in the CA3 area of the rats in the rehabilitation group was significantly shorter compared with that in the model group. The PS amplitude in the rehabilitation group was significantly higher compared with that in the model group. Furthermore, the opening probability of the NMDA receptor channel in the rehabilitation group was significantly higher compared with that in the model group. In conclusion, exercise training improved the opening conductance level, time and probability of NMDA receptor channels and accelerated the formation of learning‑dependent LTP in the contralateral hippocampal CA3 area.
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Copy and paste a formatted citation
Spandidos Publications style
Yu Q, Li X, Wang J and Li Y: Effect of exercise training on long‑term potentiation and NMDA receptor channels in rats with cerebral infarction. Exp Ther Med 6: 1431-1436, 2013.
APA
Yu, Q., Li, X., Wang, J., & Li, Y. (2013). Effect of exercise training on long‑term potentiation and NMDA receptor channels in rats with cerebral infarction. Experimental and Therapeutic Medicine, 6, 1431-1436. https://doi.org/10.3892/etm.2013.1319
MLA
Yu, Q., Li, X., Wang, J., Li, Y."Effect of exercise training on long‑term potentiation and NMDA receptor channels in rats with cerebral infarction". Experimental and Therapeutic Medicine 6.6 (2013): 1431-1436.
Chicago
Yu, Q., Li, X., Wang, J., Li, Y."Effect of exercise training on long‑term potentiation and NMDA receptor channels in rats with cerebral infarction". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1431-1436. https://doi.org/10.3892/etm.2013.1319
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Q, Li X, Wang J and Li Y: Effect of exercise training on long‑term potentiation and NMDA receptor channels in rats with cerebral infarction. Exp Ther Med 6: 1431-1436, 2013.
APA
Yu, Q., Li, X., Wang, J., & Li, Y. (2013). Effect of exercise training on long‑term potentiation and NMDA receptor channels in rats with cerebral infarction. Experimental and Therapeutic Medicine, 6, 1431-1436. https://doi.org/10.3892/etm.2013.1319
MLA
Yu, Q., Li, X., Wang, J., Li, Y."Effect of exercise training on long‑term potentiation and NMDA receptor channels in rats with cerebral infarction". Experimental and Therapeutic Medicine 6.6 (2013): 1431-1436.
Chicago
Yu, Q., Li, X., Wang, J., Li, Y."Effect of exercise training on long‑term potentiation and NMDA receptor channels in rats with cerebral infarction". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1431-1436. https://doi.org/10.3892/etm.2013.1319
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