Pituitary stalk management during the microsurgery of craniopharyngiomas

Xiao,Gelei; Yuan,Xianrui; Yuan,Jian; Krumtally,Nadeem Akhtar; Li,Yifeng; Feng,Chengyuan; Liu,Qing; Peng,Zefeng; Li,Xuejun; Ding,Xiping

doi:10.3892/etm.2014.1561

Pituitary stalk management during the microsurgery of craniopharyngiomas

Authors:
- Gelei Xiao
- Xianrui Yuan
- Jian Yuan
- Nadeem Akhtar Krumtally
- Yifeng Li
- Chengyuan Feng
- Qing Liu
- Zefeng Peng
- Xuejun Li
- Xiping Ding
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Affiliations: Institute of Skull Base Surgery and Neurooncology at Hunan, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
Published online on: February 19, 2014 https://doi.org/10.3892/etm.2014.1561
Pages: 1055-1064

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Abstract

In the present study, 203 patients that had previously undergone microsurgery for craniopharyngiomas (CPs) between 1992 and 2012 were analyzed retrospectively on a long‑term follow‑up basis to investigate the differences in the recurrence rate and endocrine function between patients with preserved and resected pituitary stalks. To summarize the possible outcomes of microsurgery, the 203 patients were divided into 2 groups: Group A that had preserved pituitary stalks and Group B that had undergone resections of the pituitary stalk. Tumor origins and the involvement of the pituitary stalk during surgery were observed. From 2010 onwards, an ultra‑electron microscope was used postoperatively to detect whether pituitary stalk specimens were infiltrated or invaded with tumor cells. Long‑term follow‑up observations of the patients included tumor recurrence, postoperative endocrine dysfunction and visual acuity and field. Among the 203 patients, 175 patients received gross‑total resection (GTR) (175/203, 86.2%), 28 patients underwent subtotal resection (28/203, 13.8%) and 34 patients had surgery that preserved the pituitary stalk (34/203, 16.7%). There was no significant difference in the recurrence rate between Group A (4/34, 11.8%) and the patients in Group B (10/123, 8.1%) who underwent GTR and also received follow‑ups. Of the 157 patients who were followed up, 91 individuals underwent endocrine evaluation and the outcome was divided into normal, satisfactory and poor grades. The results for Group A were 5, 18 and 0, respectively, while the results for Group B were 1, 60 and 7, respectively, which showed a statistically significant difference between the groups. Pituitary stalk specimens of 15 patients were studied postoperatively using an ultra‑electron microscope and all samples showed tumor cells had invaded the pituitary stalk (15/15, 100%). Total resections of CPs with the pituitary stalk were recommended if the pituitary stalk was intraoperatively invaded. In cases where the pituitary stalk was not involved, microsurgical excisions preserving the pituitary stalk were preferred, as there was no significant increase in the recurrence rate and the patients experienced less endocrine dysfunction.

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