Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus

  • Authors:
    • Yong Su
    • Ya-Li Su
    • Li-Fang Lv
    • Li-Min Wang
    • Quan-Zhong Li
    • Zhi-Gang Zhao
  • View Affiliations

  • Published online on: March 27, 2014     https://doi.org/10.3892/etm.2014.1637
  • Pages: 1752-1756
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Abstract

The aim of this study was to assess the efficacy of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus. Type II diabetic patients exhibiting poor glycemic control following α-glucosidase inhibitor treatment for at least two months were selected and randomly distributed into vildagliptin and placebo groups. The body weight, fasting blood glucose (FBG), postprandial glucose (PPG), glycated hemoglobin (HBA1c) and blood lipid levels and hepatorenal functions of the patients were determined before and 12 weeks after the trial. Following the trial, the FBG, PPG, HbA1c, cholesterol (CHOL) and triglyceride (TG) levels in the vildagliptin group were significantly decreased compared with the pretreatment levels (P<0.05), whereas only the PPG level in the placebo group decreased (P<0.05). The FBG, PPG and HbA1c levels in the vildagliptin group were markedly lower than those in the placebo group 12 weeks after the trial. A comparison of the body weights and hepatorenal functions before and after the trial or between groups did not show statistically significant differences. The combination therapy of vildagliptin plus an α-glucosidase inhibitor effectively reduced the FBG, PPG and HbA1c levels in patients without inducing weight gain or hepatorenal dysfunction. However, the therapy may have caused a reduction in the blood lipid levels.
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June-2014
Volume 7 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Su Y, Su Y, Lv L, Wang L, Li Q and Zhao Z: Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus. Exp Ther Med 7: 1752-1756, 2014.
APA
Su, Y., Su, Y., Lv, L., Wang, L., Li, Q., & Zhao, Z. (2014). Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus. Experimental and Therapeutic Medicine, 7, 1752-1756. https://doi.org/10.3892/etm.2014.1637
MLA
Su, Y., Su, Y., Lv, L., Wang, L., Li, Q., Zhao, Z."Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus". Experimental and Therapeutic Medicine 7.6 (2014): 1752-1756.
Chicago
Su, Y., Su, Y., Lv, L., Wang, L., Li, Q., Zhao, Z."Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1752-1756. https://doi.org/10.3892/etm.2014.1637