Effect of emodin on the cariogenic properties of Streptococcus mutans and the development of caries in rats

  • Authors:
    • Jing-Shu Xu
    • Yun Cui
    • Xian-Min Liao
    • Xiao-Bin Tan
    • Xue Cao
  • View Affiliations

  • Published online on: July 21, 2014     https://doi.org/10.3892/etm.2014.1857
  • Pages: 1308-1312
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Abstract

Emodin is an active herbal component traditionally used in East Asian countries for treating a variety of diseases. The present study investigated the effects of emodin on specific virulence factors of Streptococcus mutans (S. mutans) in vitro and on caries development in vivo. The growth and acid production of S. mutans were significantly inhibited by emodin (0.5‑2 mg/ml). Emodin also significantly suppressed the synthesis of insoluble glucans by S. mutans. Furthermore, the topical application of emodin reduced the incidence and severity of carious lesions in rats. These results suggest that the natural compound emodin may be a novel pharmacological agent for the prevention and treatment of dental caries.
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October 2014
Volume 8 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xu J, Cui Y, Liao X, Tan X and Cao X: Effect of emodin on the cariogenic properties of Streptococcus mutans and the development of caries in rats. Exp Ther Med 8: 1308-1312, 2014.
APA
Xu, J., Cui, Y., Liao, X., Tan, X., & Cao, X. (2014). Effect of emodin on the cariogenic properties of Streptococcus mutans and the development of caries in rats. Experimental and Therapeutic Medicine, 8, 1308-1312. https://doi.org/10.3892/etm.2014.1857
MLA
Xu, J., Cui, Y., Liao, X., Tan, X., Cao, X."Effect of emodin on the cariogenic properties of Streptococcus mutans and the development of caries in rats". Experimental and Therapeutic Medicine 8.4 (2014): 1308-1312.
Chicago
Xu, J., Cui, Y., Liao, X., Tan, X., Cao, X."Effect of emodin on the cariogenic properties of Streptococcus mutans and the development of caries in rats". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1308-1312. https://doi.org/10.3892/etm.2014.1857