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Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet

  • Authors:
    • Raluca Ecaterina Haliga
    • Veronica Mocanu
    • Magda Badescu

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  • Published online on: December 3, 2014     https://doi.org/10.3892/etm.2014.2102
  • Pages: 533-538
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Abstract

Oxidative stress has previously been shown to play a role in the pathogenesis of diabetes mellitus (DM) and its complications. In the present study, the effects of supplementation with dietary antioxidants, flaxseed and α‑tocopherol were investigated in diabetic golden Syrian hamsters fed with a high‑fat diet. Thirty‑five golden Syrian hamsters were randomly divided into a control group (C) and four diabetic groups (DM, DM + flax, DM + E and DM + Flax + E). The hamsters received four different diets for a 20‑week period, as follows: i) Groups C and DM received a high‑fat diet (40% energy as fat), deficient in α‑linolenic acid (ALA); ii) the DM + Flax group received a high‑fat diet enriched with ground flaxseed 15 g/100 g of food, rich in ALA; iii) the DM + E group received a high‑fat diet enriched with vitamin E, 40 mg α‑tocopherol/100 g of food; and iv) the DM + Flax + E group received a high‑fat diet enriched with flaxseed and vitamin E. The results of serum lipid and oxidative stress analysis suggested that the antiatherogenic effect of flaxseed, α‑tocopherol and their combination added to a high‑fat diet in diabetic hamsters was based primarily on their antioxidative role, demonstrated by decreased serum lipid peroxidation and increased liver glutathione content. Improvements of serum glucose and non‑high‑density lipoprotein cholesterol (HDL-C) levels were observed and may have contributed to the prevention of diabetic macroangiopathy evidenced in the histopathological examination. The antioxidant effect of flaxseed was similar to that of α‑tocopherol in diabetic hamsters fed a high‑fat diet and combined supplementation did not appear to bring more benefits than flaxseed alone. Moreover, the high dose of ground flaxseed alone may have a better cardioprotective effect than α‑tocopherol in diabetic hamsters by reducing total cholesterol and non‑HDL-C levels and increasing HDL‑C levels.
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February-2015
Volume 9 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Haliga RE, Mocanu V and Badescu M: Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet. Exp Ther Med 9: 533-538, 2015.
APA
Haliga, R.E., Mocanu, V., & Badescu, M. (2015). Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet. Experimental and Therapeutic Medicine, 9, 533-538. https://doi.org/10.3892/etm.2014.2102
MLA
Haliga, R. E., Mocanu, V., Badescu, M."Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet". Experimental and Therapeutic Medicine 9.2 (2015): 533-538.
Chicago
Haliga, R. E., Mocanu, V., Badescu, M."Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet". Experimental and Therapeutic Medicine 9, no. 2 (2015): 533-538. https://doi.org/10.3892/etm.2014.2102