Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review)

  • Authors:
    • Chong Di
    • Yaodong Zhao
  • View Affiliations

  • Published online on: December 16, 2014     https://doi.org/10.3892/etm.2014.2141
  • Pages: 289-293
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Abstract

In recent years, the cancer stem cell (CSC) theory has provided a new angle in the research of cancer, and has gradually gained significance. According to this theory, the multiple drug resistance (MDR) of cancer is most likely due to the resistance of CSCs, and a significant quantity of research has been carried out into the MDR mechanisms of CSC. Over time, some of these mechanisms have been gradually accepted, including ATP‑binding cassette transporters, aldehyde dehydrogenase, the CSC microenvironment and epithelial to mesenchymal transition. In the present review, we summarize these mechanisms in detail and review possible appropriate therapy plans against CSCs based on CSC theory.
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February-2015
Volume 9 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Di C and Zhao Y: Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review). Exp Ther Med 9: 289-293, 2015.
APA
Di, C., & Zhao, Y. (2015). Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review). Experimental and Therapeutic Medicine, 9, 289-293. https://doi.org/10.3892/etm.2014.2141
MLA
Di, C., Zhao, Y."Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review)". Experimental and Therapeutic Medicine 9.2 (2015): 289-293.
Chicago
Di, C., Zhao, Y."Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review)". Experimental and Therapeutic Medicine 9, no. 2 (2015): 289-293. https://doi.org/10.3892/etm.2014.2141