Doxapram hastens the recovery following total intravenous anesthesia with dexmedetomidine, propofol and remifentanil

Wang,Huan‑Liang; Tang,Shu‑Hai; Wang,Xue‑Qin; Gong,Wen‑Hua; Liu,Xiao‑Mei; Lei,Wei‑Fu

doi:10.3892/etm.2015.2249

Doxapram hastens the recovery following total intravenous anesthesia with dexmedetomidine, propofol and remifentanil

Authors:
- Huan‑Liang Wang
- Shu‑Hai Tang
- Xue‑Qin Wang
- Wen‑Hua Gong
- Xiao‑Mei Liu
- Wei‑Fu Lei
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Affiliations: Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China
Published online on: February 2, 2015 https://doi.org/10.3892/etm.2015.2249
Pages: 1518-1522

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Abstract

Dexmedetomidine is a suitable sedative for awake fiberoptic intubation in patients with obstructive sleep apnea (OSA). However, previous studies have shown that dexmedetomidine delays recovery from propofol‑remifentanil anesthesia. This study aimed to determine whether doxapram may hasten the recovery following dexmedotomidine‑propofol‑remifentanil anesthesia. Sixty patients scheduled for uvulopalatopharyngoplasty with total intravenous anesthesia were randomized to two groups according to the medicine given at the end of surgery. These were the doxapram (1 mg/kg) and control (normal saline) groups (n=30 per group). The primary outcome was the time to eye opening on verbal command. The time to return to spontaneous breathing, to hand squeezing in response to verbal command, to extubation of the trachea, and the heart rate (HR), bispectral index (BIS) values, respiratory rate (RR) and pulse oximetry values were also recorded and compared. The time to return to spontaneous breathing (5.2±2.9 vs. 11.7±3.4 min, P<0.001), eye opening (9.3±4.7 vs. 15.9±6.3 min, P<0.001), hand squeeze to command (11.8±6.5 vs. 17.6±7.7 min, P=0.0026) and extubation (14.2±7.8 vs. 19.2±9.6 min, P=0.0308) were significantly shorter in the doxapram group compared with the control group. BIS scores (at 3‑14 min), RR (at 4‑10 min) and HR (at 2‑13 min) were significantly higher in the doxapram group compared with those in the control group (P<0.05). Doxapram hastens the recovery from dexmedetomidine‑propofol‑remifentanil anesthesia in patients undergoing uvulopalatopharyngoplasty, and may benefit patients with OSA.

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