A lack of association between the IKZF2 rs12619285 polymorphism and coronary heart disease

Ye,Huadan; Hong,Qingxiao; Li,Yirun; Xu,Xuting; Huang,Yi; Xu,Limin; Zhou,Annan; Deng,Youping; Duan,Shiwei

doi:10.3892/etm.2015.2282

A lack of association between the IKZF2 rs12619285 polymorphism and coronary heart disease

Authors:
- Huadan Ye
- Qingxiao Hong
- Yirun Li
- Xuting Xu
- Yi Huang
- Limin Xu
- Annan Zhou
- Youping Deng
- Shiwei Duan
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Affiliations: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Department of Neurosurgery, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. China, Rush University Cancer Center, and Department of Internal Medicine and Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA
Published online on: February 10, 2015 https://doi.org/10.3892/etm.2015.2282
Pages: 1309-1313

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Abstract

The IKZF2 rs12619285 polymorphism is associated with the eosinophil count, which has multidimensional functions in the pathogenesis of coronary heart disease (CHD). The aim of the present study was to investigate the contribution of the IKZF2 rs12619285 polymorphism to the risk of CHD in a Han Chinese population. In total, 721 CHD cases and 631 non‑CHD controls were recruited for an association study of the IKZF2 rs12619285 polymorphism. Genotyping was performed using the melting temperature‑shift polymerase chain reaction method. No statistically significant association was observed between the IKZF2 rs12619285 polymorphism and CHD (odds ratio, 1.139, 95% confidence interval, 0.927‑1.334; P=0.17). In addition, subgroup analyses by gender or age were unable to identify any association between IKZF2 rs12619285 and CHD (P>0.05), and there was no significant correlation between IKZF2 rs12619285 and the severity of CHD (P>0.05). The power of the case‑control study was determined to be 63.3%. In addition, the G allele frequency was calculated as 63.6% in the Han Chinese population, which was similar to the 59.3% recorded for the HapMap Chinese population of Han Chinese individuals living in Beijing, compared with 24.3% in European descendents (HapMap‑CEU). Therefore, the results indicated that the IKZF2 rs12619285 polymorphism was not associated with CHD in a Han Chinese population. The discrepancy in the association between rs12619285 and CHD may be due to the ethnic differences between Han Chinese and European populations.

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