Pediatric patients with inflammatory bowel disease exhibit increased serum levels of proinflammatory cytokines and chemokines, but decreased circulating levels of macrophage inhibitory protein-1β, interleukin-2 and interleukin-17

Kleiner,Giulio; Zanin,Valentina; Monasta,Lorenzo; Crovella,Sergio; Caruso,Lorenzo; Milani,Daniela; Marcuzzi,Annalisa

doi:10.3892/etm.2015.2370

Pediatric patients with inflammatory bowel disease exhibit increased serum levels of proinflammatory cytokines and chemokines, but decreased circulating levels of macrophage inhibitory protein-1β, interleukin-2 and interleukin-17

Authors:
- Giulio Kleiner
- Valentina Zanin
- Lorenzo Monasta
- Sergio Crovella
- Lorenzo Caruso
- Daniela Milani
- Annalisa Marcuzzi
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Affiliations: Department of Advanced Diagnostic and Clinical Trials, Institute for Maternal and Child Health - IRCCS ‘Burlo Garofolo’, Trieste 34137, Italy, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara 44121, Italy
Published online on: March 19, 2015 https://doi.org/10.3892/etm.2015.2370
Pages: 2047-2052
Copyright: © Kleiner et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory condition of the gastrointestinal tract. Although the causative events that lead to the onset of IBD are yet to be fully elucidated, deregulation of immune and inflammatory mechanisms are hypothesized to significantly contribute to this disorder. Since the onset of IBD is often during infancy, in the present study, the serum values of a large panel of cytokines and chemokines in pediatric patients (<18 years; n=26) were compared with age‑matched controls (n=37). While elevations in the serum level of several proinflammatory and immune regulating cytokines were confirmed, such as interleukin (IL)‑1β, IL‑5, IL‑7, interferon (IFN)‑γ‑inducible protein‑10, IL‑16, cutaneous T‑cell‑attracting chemokine, leukemia inhibitory factor, monokine induced by γ‑IFN, IFN‑α2 and IFN‑γ, notably decreased levels of IL‑2, IL‑17 and macrophage inhibitory protein‑1β were also observed. Therefore, while a number of proinflammatory cytokines exhibit increased levels in IBD patients, pediatric IBD patients may also exhibit certain aspects of a reduced immunological response.

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