Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant

Cao,Li‑Hua; Li,Yun‑Ru; Wang,Shou‑Yun; Liu,Zhi‑Min; Sun,Shao‑Chun; Xu,Dong‑Bo; Zhang,Ji‑Dong

doi:10.3892/etm.2015.2483

Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant

Authors:
- Li‑Hua Cao
- Yun‑Ru Li
- Shou‑Yun Wang
- Zhi‑Min Liu
- Shao‑Chun Sun
- Dong‑Bo Xu
- Ji‑Dong Zhang
View Affiliations

Affiliations: Liver Disease Center, Qinhuangdao Third Hospital, Qinhuangdao, Hebei 066001, P.R. China, The Affiliated Beijing Ditan Hospital, Capital Medical University, Beijing 100000, P.R. China, Qinhuangdao Women and Children's Hospital, Qinhuangdao, Hebei 066000, P.R. China
Published online on: May 8, 2015 https://doi.org/10.3892/etm.2015.2483
Pages: 279-284

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The aim of the present study was to investigate the effects of vaccination with the hepatitis B vaccine (HBVac) in HB surface antibody (HBsAb)‑negative pregnant mothers on the vertical transmission of HB virus (HBV) from father to infant. All the fathers tested positive for the serum HBV DNA and HB surface antigen (HBsAg) markers. The pregnant females were divided into an observation group or a control group depending on whether their serum was HBsAb‑negative or positive. A total of 93 healthy individuals without HBV infection were included in a blank group, while 96 females who were serum HBV marker‑negative or HB core antibody (HBcAb)‑positive/(HBsAb)‑negative were included in the observation group. The control group comprised 89 females who all tested positive for serum HBsAb, HB envelope antibodies and HBcAb. In the observation group, the positive rate of HBV DNA in the newborns was 7.29% (7/96), the positive rate of HBsAg was 3.13% (3/96) and the positive rate of HBsAb was 81.3% (78/96). In the control group, the positive rates of HBV DNA, HBsAg and HBsAb in the newborns were 4.49% (4/89), 2.25% (2/89) and 89.9% (80/89), respectively. No statistically significant differences were observed between the two groups. Therefore, the results of the present study indicate that HBVac treatment for HBsAb‑negative pregnant females may have a positive role in blocking the vertical transmission of HBV from father to infant, as long as the vaccination is able to induce the production of a sufficient quantity of HBsAb. The HBVac exhibited no difference compared with pre‑pregnancy HBsAb in blocking the vertical transmission of HBV from father to infant.

View Figures

View References

1	Blumberg BS: Australia antigen and the biology of hepatitis B. Science. 197:17–25. 1977. View Article : Google Scholar : PubMed/NCBI
2	Huang JM, Huang TH, Qiu HY, Fang XW, Zhuang TG and Qiu JW: Studies on the integration of hepatitis B virus DNA sequence in human sperm chromosomes. Asian J Androl. 4:209–212. 2002.PubMed/NCBI
3	Araki K, Miyazaki J, Hino O, Tomita N, Chisaka O, Matsubara K and Yamamura K: Expression and replication of hepatitis B virus genome in transgenic mice. Proc Natl Acad Sci USA. 86:207–211. 1989. View Article : Google Scholar : PubMed/NCBI
4	Ali BA, Huang TH and Xie QD: Detection and expression of hepatitis B virus X gene in one and two-cell embryos from golden hamster oocytes in vitro fertilized with human spermatozoa carrying HBV DNA. Mol Reprod Dev. 70:30–36. 2005. View Article : Google Scholar : PubMed/NCBI
5	Ali BA, Huang TH, Salem HH and Xie QD: Expression of hepatitis B virus genes in early embryonic cells originated from hamster ova and human spermatozoa transfected with the complete viral genome. Asian J Androl. 8:273–279. 2006. View Article : Google Scholar : PubMed/NCBI
6	Zhuang YL: Influence of viral hepatitis during pregnancy on perinatal infants. Zhongguo Shi Yong Fu Ke Yu Chan Ke Za Zhi. 11:144–145. 1995.(In Chinese).
7	Zhang XW and Yang L: Clinical study on the way of blocking the father-child transmission of hepatitis B virus. Lin Chuang Gan Dan Bing Za Zhi. 15:172–174. 1999.(In Chinese).
8	Ni XP and Zeng XY: Comparison of the vertical transmission of HBV from father to infant in pre-pregnancy mothers with or without HBsAb. Shi Yong Zhong Xi Yi Jie He Za Zhi. 6:56–57. 2006.(In Chinese).
9	Chen ZQ and She YP: A study of interrupting the vertical transmission of hepatitis B virus from father to infant. Hua Xia Yi Xue. 26:930–932. 2013.(In Chinese).
10	You K: Advanced research of block the hepatitis B virus transmission from father to infant. Nei Ke. 1:60–61. 2006.(In Chinese).
11	Zhu KL, Zhu ZM, Zeng WZ and Liang JX: Recent advances in research of nucleotide in preventing mother-to-infant transmission of hepatitis B virus. Guangzhou Yi Yao. 43:1–2. 2012.(In Chinese).
12	Zhang P, Lu W, Sun Z, Liu Y and Liu XL: Clinical study on blocking paternal fetal transmission of hepatitis B virus. Zhonghua Chuan Ran Bing Za Zhi. 28:688–689. 2010.(In Chinese).
13	Ayoola EA and Johnson AO: Hepatitis B vaccine in pregnancy: Immunogenecity, safety and transfer of antibodies to infants. Int J Gynaecol Obstet. 25:297–301. 1987. View Article : Google Scholar : PubMed/NCBI
14	Zhu KL, Zhu ZM, Zeng WZ and Liang JX: Recent advances in research of nucleotide in preventing mother-to-infant transmission of hepatitis B virus. Guangzhou Yi Yao. 43:1–2. 2012.(In Chinese).
15	Komatsu H, Inui A, Sogo T, Hiejima E, Kudo N and Fujisawa T: Source of transmission in children with chronic hepatitis B infection after the implementation of a strategy for prevention in those at high risk. Hepatol Res. 39:569–576. 2009. View Article : Google Scholar : PubMed/NCBI
16	Chen SP and Zhang RL: Investigation on blocking paternal transmission of hepatitis B. Hai Xia Yao Xue. 21:32–35. 2009.(In Chinese).
17	Li SX: Clinical study on human hepatitis B immunoglobulin plus recombinant hepatitis B vaccine for controlled transmission of HBV from father to infant. Zhong Guo Chu Ji Wei Sheng Bao Jian Za Zhi She. 20:65–66. 2006.(In Chinese).
18	Livezey KW, Negorev D and Simon D: Increased chromosomal alterations and micronuclei formation in human hepatoma HepG2 cells transfected with the hepatitis B virus HBX gene. Mutat Res. 505:63–74. 2002. View Article : Google Scholar : PubMed/NCBI
19	Huang JM, Huang TH, Qiu HY, Fang XW, Zhuang TG, Liu HX, Wang YH, Deng LZ and Qiu JW: Effects of hepatitis B virus infection on human sperm chromosomes. World J Gastroenterol. 9:736–740. 2003.PubMed/NCBI
20	Vicari E, Arcoria D, Di Mauro C, Noto R, Noto Z and La Vignera S: Sperm output in patients with primary infertility and hepatitis B or C virus; negative influence of HBV infection during concomitant varicocele. Minerva Med. 97:65–77. 2006.PubMed/NCBI
21	Ye F, Liu Y, Jin Y, Shi J, Yang X, Liu X, Zhang X, Lin S, Kong Y and Zhang L: The effect of hepatitis B virus infected embryos on pregnancy outcome. Eur J Obstet Gynecol Reprod Biol. 172:10–14. 2014. View Article : Google Scholar : PubMed/NCBI
22	Wang SS, Li WL, Peng GF, Li MM, Xiao H, Jin HL, Zeng NH, Wang ZB and Su JX: Analysis of hepatitis B virus S gene phylogenetic tree of paternal fetal transmission. Zhong Hua Yi Xue Za Zhi. 83:451–454. 2003.(In Chinese).
23	He JQ, Yuan SH, Xian GJ, Chen YM and Yang YL: Study of hepatitis B virus vertical transmission from father to infant. Shi Yong Fu Chan Ke Za Zhi. 21:301–303. 2005.(In Chinese).
24	Sheffield JS, Hickman A, Tang J, Moss K, Kourosh A, Crawford NM and Wendel GD Jr: Efficacy of an accelerated hepatitis B vaccination program during pregnancy. Obstet Gynecol. 117:1130–1135. 2011. View Article : Google Scholar : PubMed/NCBI
25	Chen H, Wang XZ and Lu X: The case report and analysis of positive hepatitis B virus antigen converse negative in neonatal intra-uterine. Zhongguo Xin Sheng Er Ke Za Zhi. 22:306–307. 2007.(In Chinese).
26	Jia QQ and Gu Y: The blocking effect of hepatitis B immunoglobulin on HBV intrauterine infection and its indication. Zhong Guo Xin Sheng Er Ke Za Zhi. 16:196–197. 2001.(In Chinese).
27	Zhang P, Zhu LZ, Zhang YR, Li W, Cheng J and Hao JY: The clinical observation of intrauterine infection of HBV during pregnancy. Tianjin Yi Yao. 32:217–218. 2004.(In Chinese).