Fibroblastic reticular cell tumor of the breast: A case report and review of the literature

Li,Hongmei; Shen,Pingrong; Liang,Yun; Zhang,Feng

doi:10.3892/etm.2015.2922

Fibroblastic reticular cell tumor of the breast: A case report and review of the literature

Authors:
- Hongmei Li
- Pingrong Shen
- Yun Liang
- Feng Zhang
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Affiliations: Department of Pathology, Ninghai Maternity and Child Care Hospital, Ninghai, Zhejiang 315600, P.R. China, Department of Gynaecology and Obstetrics, Ninghai Maternity and Child Care Hospital, Ninghai, Zhejiang 315600, P.R. China, Department of Pathology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China, Department of Surgery, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China
Published online on: December 8, 2015 https://doi.org/10.3892/etm.2015.2922
Pages: 561-564

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Abstract

Fibroblastic reticular cells (FBRCs) are basic mesenchymal cells that belong to the dendritic cell family. Primary extranodal FBRC tumor (FRCT) cases are rare, with only 19 cases reported in the literature thus far. However, none of these cases originated in the breast tissue. To the best of our knowledge, the present study reported the first FRCT case of the breast in a 57‑year‑old woman. The patient complained of a painless mass that was located in the right breast and was ~3.5x2.5 cm in size. The patient underwent modified radical mastectomy subsequent to the diagnosis of FRCT after analysis of the lumpectomy specimen. Pathological examination revealed that the tumor was mainly composed of oval and spindle cells, and was infiltrated with lymphocytes and plasma cells. The tumor cells were immunoreactive for vimentin and negative for CD21, CD35 and S‑100 protein. Six axillary lymph nodes were found to have been involved. Following surgery, the patient received four cycles of mesna, doxorubicin, ifosfamide and dacarbazine regimen chemotherapy (70 mg adriamycin day 1; 2.0 g ifosfamided days 1-3; 0.4 g dacarbazine day 1-3), which cycled every 21 days. The patient was uneventfully followed‑up for 20 months following chemotherapy. In conclusion, the present study reported what appeared to be the first case of primary breast FRCT. The diagnosis, treatment and prognosis details presented in this study will help improve the diagnosis of the disease.

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1	Wu L and Liu YJ: Development of dendritic-cell lineages. Immunity. 26:741–750. 2007. View Article : Google Scholar : PubMed/NCBI
2	Sato K and Fujita S: Dendritic cells: Nature and classification. Allergol Int. 56:183–191. 2007. View Article : Google Scholar : PubMed/NCBI
3	Balogh P, Fisi V and Szakal AK: Fibroblastic reticular cells of the peripheral lymphoid organs, Unique features of a ubiquitous cell type. Mol Immunol. 46:1–7. 2008. View Article : Google Scholar : PubMed/NCBI
4	Andriko JW, Kaldjian EP, Tsokos M, Abbondanzo SL and Jaffe ES: Reticulum cell neoplasms of lymph nodes, A clinicopathologic study of 11 cases with recognition of a new subtype derived from fibroblastic reticular cells. Am J Surg Pathol. 22:1048–1058. 1998. View Article : Google Scholar : PubMed/NCBI
5	Gould VE, Warren WH, Faber LP, Kuhn C and Franke WW: Malignant cells of epithelial phenotype limited to thoracic lymph nodes. Eur J Cancer. 26:1121–1126. 1990. View Article : Google Scholar : PubMed/NCBI
6	Chan ACL, Serrano-Olmo J, Erlandson RA and Rosai J: Cytokeratin-positive malignant tumors with reticulum cell morphology, A subtype of fibroblastic reticulum cell neoplasm? Am J Surg Pathol. 24:107–116. 2000. View Article : Google Scholar : PubMed/NCBI
7	Jones D, Amin M, Ordonez NG, Glassman AB, Hayes KJ and Medeiros LJ: Reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features. Mod Pathol. 14:1059–1067. 2001. View Article : Google Scholar : PubMed/NCBI
8	Lucioni M, Boveri E, Rosso R, Benazzo M, Necchi V, Danova M, Incardona P, Franco C, Viglio A, Riboni R, et al: Lymph node reticulum cell neoplasm with progression into cytokeratin-positive interstitial reticulum cell sarcoma (CIRC): A case study. Histopathology. 43:583–591. 2003. View Article : Google Scholar : PubMed/NCBI
9	Martel M, Sarli D, Colecchia M, Coppa J, Romito R, Schiavo M, Mazzaferro V and Rosai J: Fibroblastic reticular cell tumor of the spleen, Report of a case and review of the entity. Hum Pathol. 34:954–957. 2003. View Article : Google Scholar : PubMed/NCBI
10	Schuerfeld K, Lazzi S, De Santi MM, Gozzetti A, Leoncini L and Pileri SA: Cytokeratin-positive interstitial cell neoplasm, A case report and classification issues. Histopathology. 43:491–494. 2003. View Article : Google Scholar : PubMed/NCBI
11	Mücke R, Reichl B, Micke O, Heyder R, Büntzel J, Marx A, Müller-Hermelink HK and Ott G: Surgery and radiotherapy of one rare case with neoplasm derived from fibroblastic reticulum cells of a cervical lymph node. Acta Oncol. 43:766–768. 2004. View Article : Google Scholar : PubMed/NCBI
12	Dong YC, Wu B, Sheng Z, Wang JD, Zhou HB and Zhou XJ: Cytokeratin-positive interstitial reticulum cell tumors of lymph nodes, A case report and review of literature. Chin Med J (Engl). 121:658–663. 2008.PubMed/NCBI
13	Kwon JE, Yang W-I, Kim HK, Kwon KW, Kwon TJ, Choi EC and Lee KG: Cytokeratin-positive interstitial reticulum cell sarcoma: A case report with cytological, immunohistochemical, and ultrastructural findings. Cytopathology. 20:202–205. 2009. View Article : Google Scholar : PubMed/NCBI
14	Yaman E, Gonul II, Buyukberber S, Ozturk B, Akyurek N, Coskun U, Kaya AO, Yildiz R, Sare M and Kitapci M: Metastatic fibroblastic reticulum cell sarcoma of the liver, Pathological and PET-CT evaluation. Pathology. 41:289–292. 2009. View Article : Google Scholar : PubMed/NCBI
15	Suárez D, Izquierdo FM, Méndez JR, Escobar J, Cabeza A and Junco P: Tumor of fibroblastic reticular cells of lymph node coincidental with an undifferentiated endometrial stromal sarcoma. Histopathology. APMIS. 119:216–220. 2011. View Article : Google Scholar : PubMed/NCBI
16	Omoto Y, Kurosumi M, Hozumi Y, Oba H, Kawanowa K, Takei H and Yasuda Y: Immunohistochemical assessment of primary breast tumors and metachronous brain metastases, with particular regard to differences in the expression of biological markers and prognosis. Exp Ther Med. 1:561–567. 2010.PubMed/NCBI
17	Vardiman JW: TheW orld Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: An overview with emphasis on the myeloid neoplasms. Chem Biol Interact. 184:16–20. 2010. View Article : Google Scholar : PubMed/NCBI
18	Saygin C, Uzunaslan D, Ozguroglu M, Senocak M and Tuzuner N: Dendritic cell sarcoma, A pooled analysis including 462 cases with presentation of our case series. Crit Rev Oncol Hematol. 88:253–271. 2013. View Article : Google Scholar : PubMed/NCBI
19	Fingeroth JD, Weis JJ, Tedder TF, Strominger JL, Biro PA and Fearon DT: Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci USA. 81:4510–4514. 1984. View Article : Google Scholar : PubMed/NCBI
20	Lindhout E, Lakeman A, Mevissen ML and de Groot C: Functionally active Epstein-Barr virus-transformed follicular dendritic cell-like cell lines. J Exp Med. 179:1173–1184. 1994. View Article : Google Scholar : PubMed/NCBI
21	Kapucuoglu N, Percinel S, Ventura T, Lang R, Al-Daraji W and Eusebi V: Dendritic cell sarcomas/tumours of the breast, Report of two cases. Virchows Arch. 454:333–339. 2009. View Article : Google Scholar : PubMed/NCBI
22	Uluoğlu O, Akyürek N, Uner A, Coşkun U, Ozdemir A and Gökçora N: Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement A case report and review of the literature. Virchows Arch. 446:546–554. 2005. View Article : Google Scholar : PubMed/NCBI
23	Fraser CR, Wang W, Gomez M, Zhang T, Mathew S, Furman RR, Knowles DM, Orazi A and Tam W: Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma, Evidence for transdifferentiation of the lymphoma clone. Am J Clin Pathol. 132:928–939. 2009. View Article : Google Scholar : PubMed/NCBI
24	Franke WW and Moll R: Cytoskeletal components of lymphoid organs. Histopathology. Differentiation. 36:145–163. 1987. View Article : Google Scholar : PubMed/NCBI
25	Sundersingh S, Majhi U, Krishnamurthy A and Velusami SD: Cytokeratin-positive interstitial reticulum cell sarcoma, Extranodal presentations mimicking carcinoma. Indian J Pathol Microbiol. 56:172–175. 2013. View Article : Google Scholar : PubMed/NCBI
26	Pruneri G, Masullo M, Renne G, Taccagni G, Manzotti M, Luini A and Viale G: Follicular dendritic cell sarcoma of the breast. Virchows Arch. 441:194–199. 2002. View Article : Google Scholar : PubMed/NCBI
27	Gaertner EM, Tsokos M, Derringer GA, Neuhauser TS, Arciero C and Andriko JA: Interdigitating dendritic cell sarcoma, A report of four cases and review of the literature. Am J Clin Pathol. 115:589–597. 2001. View Article : Google Scholar : PubMed/NCBI
28	Toesca A, Spitaleri G, De Pas T, Botteri E, Gentilini O, Bottiglieri L, Rotmentsz N, Sangalli C, Marrazzo E, Cassano E, et al: Sarcoma of the breast: Outcome and reconstructive options. Clin Breast Cancer. 12:438–444. 2012. View Article : Google Scholar : PubMed/NCBI