Open Access

GS/DBM/PLA porous composite biomaterial for the treatment of infective femoral condyle defect in rats

  • Authors:
    • Xiaoming Liu
    • Lin Yang
    • Jing Li
    • Yuming Zhang
    • Weijun Xu
    • Yan Ren
    • Biwang Liu
    • Biao Yang
    • Baoxing Li
  • View Affiliations

  • Published online on: April 1, 2016     https://doi.org/10.3892/etm.2016.3219
  • Pages: 2107-2116
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A bone defect resulting from open bone trauma may easily become infected; however, the administration of efficacious systemic antibiotics cannot be performed at safe levels. Previous studies have investigated anti‑infective biomaterials that incorporate into bone and facilitate the direct application of high‑concentration local antibiotics. In the present study, the effect of a novel porous composite with gentamicin sulfate (GS) in treating infected femoral condyle defects was investigated using a rat model. A novel porous composite biomaterial was prepared based on a supercritical carbon dioxide fluid technique that combined GS, demineralized bone matrix (DBM) and polylactic acid (PLA). A rat femoral condyle fracture model of infection was established. The GS/DBM/PLA composite biomaterial was implanted and its physicochemical characteristics, biocompatibility and ability to facilitate repair of infected bone defect were assessed. The GS/DBM/PLA composite biomaterial maintained the antibiotic activity of GS, with good anti‑compression strength, porosity and biocompatibility. The results of the animal experiments indicated that the GS/DBM/PLA composite biomaterial exerted marked anti‑infective effects and facilitated bone defect repair, while simultaneously controlling infection. Porous GS/DBM/PLA is therefore a promising composite biomaterial for use in bone tissue engineering.
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June-2016
Volume 11 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu X, Yang L, Li J, Zhang Y, Xu W, Ren Y, Liu B, Yang B and Li B: GS/DBM/PLA porous composite biomaterial for the treatment of infective femoral condyle defect in rats. Exp Ther Med 11: 2107-2116, 2016.
APA
Liu, X., Yang, L., Li, J., Zhang, Y., Xu, W., Ren, Y. ... Li, B. (2016). GS/DBM/PLA porous composite biomaterial for the treatment of infective femoral condyle defect in rats. Experimental and Therapeutic Medicine, 11, 2107-2116. https://doi.org/10.3892/etm.2016.3219
MLA
Liu, X., Yang, L., Li, J., Zhang, Y., Xu, W., Ren, Y., Liu, B., Yang, B., Li, B."GS/DBM/PLA porous composite biomaterial for the treatment of infective femoral condyle defect in rats". Experimental and Therapeutic Medicine 11.6 (2016): 2107-2116.
Chicago
Liu, X., Yang, L., Li, J., Zhang, Y., Xu, W., Ren, Y., Liu, B., Yang, B., Li, B."GS/DBM/PLA porous composite biomaterial for the treatment of infective femoral condyle defect in rats". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2107-2116. https://doi.org/10.3892/etm.2016.3219