Open Access

Roscovitine protects murine Leydig cells from lipopolysaccharide-induced inflammation

  • Authors:
    • Tiancheng Xie
    • Guanghui Hu
    • Binbin Dong
    • Yangye Yan
    • Min Liu
    • Xudong Yao
    • Junhua Zheng
    • Yunfei Xu
  • View Affiliations

  • Published online on: March 20, 2017     https://doi.org/10.3892/etm.2017.4239
  • Pages: 2169-2176
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Roscovitine is a cyclin-dependent kinase inhibitor, which has been previously investigated for its anticancer effects. It has also been confirmed that roscovitine can downregulate the expression of myeloid cell leukemia‑1 protein to inhibit inflammation. In the present study, roscovitine was used to treat inflammation in lipopolysaccharide (LPS)-induced model mice. At the cellular level, Leydig cells isolated from mouse testis were assessed for inflammatory factors. It was revealed that roscovitine successfully reduced inflammation‑associated injury induced by LPS pretreatment. At the molecular level, roscovitine was found to exert this effect through promotion of adenosine monophosphate-activated protein kinase phosphorylation. To the best of our knowledge, the present study was the first to suggest that roscovitine has a protective role in Leydig cells through its anti-inflammatory action.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Xie T, Hu G, Dong B, Yan Y, Liu M, Yao X, Zheng J and Xu Y: Roscovitine protects murine Leydig cells from lipopolysaccharide-induced inflammation. Exp Ther Med 13: 2169-2176, 2017.
APA
Xie, T., Hu, G., Dong, B., Yan, Y., Liu, M., Yao, X. ... Xu, Y. (2017). Roscovitine protects murine Leydig cells from lipopolysaccharide-induced inflammation. Experimental and Therapeutic Medicine, 13, 2169-2176. https://doi.org/10.3892/etm.2017.4239
MLA
Xie, T., Hu, G., Dong, B., Yan, Y., Liu, M., Yao, X., Zheng, J., Xu, Y."Roscovitine protects murine Leydig cells from lipopolysaccharide-induced inflammation". Experimental and Therapeutic Medicine 13.5 (2017): 2169-2176.
Chicago
Xie, T., Hu, G., Dong, B., Yan, Y., Liu, M., Yao, X., Zheng, J., Xu, Y."Roscovitine protects murine Leydig cells from lipopolysaccharide-induced inflammation". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2169-2176. https://doi.org/10.3892/etm.2017.4239