Open Access

Oral administration of lactobacilli isolated from Jeotgal, a salted fermented seafood, inhibits the development of 2,4‑dinitrofluorobenzene‑induced atopic dermatitis in mice

  • Authors:
    • Mi‑Sung Park
    • Nho‑Eul Song
    • Sang‑Ho Baik
    • Hyun‑Ock Pae
    • Seong Hoon Park
  • View Affiliations

  • Published online on: June 1, 2017     https://doi.org/10.3892/etm.2017.4536
  • Pages: 635-641
  • Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Certain strains of lactobacilli have been reported to exert favorable effects on atopic dermatitis (AD). Jeotgal, a traditional Korean food, is a salted fermented seafood known to harbor many lactic acid bacteria. In the present study, two novel lactobacillus strains were isolated from Jeotgal, and their anti‑AD effects were investigated. Lactobacilli isolated from Jeotgal were identified, according to conjugated linoleic acid‑producing activity, as Lactobacillus plantarum (JBCC105645 and JBCC105683). AD‑like skin lesions were induced in BALB/c mice using dinitrofluorobenzene (DNFB). Ear swelling, histological analysis and serum immunoglobulin E (IgE) levels in mice were evaluated to investigate the anti‑AD effects of lactobacilli. Cytokine production of ex vivo cluster of differentiation (CD)4+ T cells, and interleukin (IL)‑12 production of in vitro macrophages were also evaluated to establish a putative mechanism of the action of lactobacilli. Administration of JBCC105645 or JBCC105683 suppressed ear swelling and serum IgE levels in DNFB‑treated mice (P<0.05). Notably, JBCC105645 was more effective than JBCC105683 (P<0.05). Treatment with the lactobacilli also induced a significant decrease in IL‑4 production with concomitant increase in interferon (IFN)‑γ production in DNFB‑exposed CD4+ T cells, and an increase in IL‑12 production in macrophages (P<0.05). Taken together, the lactobacilli isolated from Jeotgal may suppress the development of AD‑like skin inflammation in mice by modulating IL‑4 and IFN‑γ production in CD4+ T cells, presumably via enhancing IL‑12 production by macrophages.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Park MS, Song NE, Baik SH, Pae HO and Park SH: Oral administration of lactobacilli isolated from Jeotgal, a salted fermented seafood, inhibits the development of 2,4‑dinitrofluorobenzene‑induced atopic dermatitis in mice. Exp Ther Med 14: 635-641, 2017.
APA
Park, M., Song, N., Baik, S., Pae, H., & Park, S.H. (2017). Oral administration of lactobacilli isolated from Jeotgal, a salted fermented seafood, inhibits the development of 2,4‑dinitrofluorobenzene‑induced atopic dermatitis in mice. Experimental and Therapeutic Medicine, 14, 635-641. https://doi.org/10.3892/etm.2017.4536
MLA
Park, M., Song, N., Baik, S., Pae, H., Park, S. H."Oral administration of lactobacilli isolated from Jeotgal, a salted fermented seafood, inhibits the development of 2,4‑dinitrofluorobenzene‑induced atopic dermatitis in mice". Experimental and Therapeutic Medicine 14.1 (2017): 635-641.
Chicago
Park, M., Song, N., Baik, S., Pae, H., Park, S. H."Oral administration of lactobacilli isolated from Jeotgal, a salted fermented seafood, inhibits the development of 2,4‑dinitrofluorobenzene‑induced atopic dermatitis in mice". Experimental and Therapeutic Medicine 14, no. 1 (2017): 635-641. https://doi.org/10.3892/etm.2017.4536