Open Access

Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis

  • Authors:
    • Jing‑Xiu Li
    • En‑Ze Jin
    • Long‑Hao Yu
    • Yang Li
    • Nan‑Nan Liu
    • Yu‑Mei Dong
    • Xin Li
    • Xue‑Qi Li
  • View Affiliations

  • Published online on: June 27, 2017     https://doi.org/10.3892/etm.2017.4678
  • Pages: 1568-1576
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It is acknowledged that contrast‑induced nephropathy (CIN) is a common cause of acute renal insufficiency after cardiac catheterization and affects mortality and morbidity. To date, it is unknown whether oral N‑acetylcysteine (NAC) is able to prevent contrast‑induced nephropathy (CIN) in patients undergoing coronary angioplasty. A meta‑analysis of randomized controlled trials was performed to assess the effects of NAC in the prevention of CIN in patients following coronary angioplasty. A total of 19 studies published prior to January 2015 that investigated the efficacy of oral NAC for the prevention of CIN were collected from Medline, Cochrane and Embase databases and conference proceedings from cardiology and nephrology meetings. The primary point of investigation was CIN, and the secondary points were renal failure requiring dialysis, mortality and length of hospitalization. The meta‑analysis was performed using fixed‑ or random‑effect models according to heterogeneity. Up to January 2015, 19 randomized placebo‑controlled clinical trials met the inclusion criteria for the meta‑analysis, including 4,514 patients. The pooled data showed that oral NAC did not reduce the CIN incidence [relative risk 0.84, 95% confidence interval (CI) 0.65‑1.10; P=0.20], without heterogeneity among trials (I2=29%). Thus, the present meta‑analysis suggests that oral NAC therapy is not effective as an alternative treatment to prevent CIN in patients following angioplasty. Further high quality randomized clinical controlled trials are required to confirm the usage and availability of this treatment.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li JX, Jin EZ, Yu LH, Li Y, Liu NN, Dong YM, Li X and Li XQ: Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis. Exp Ther Med 14: 1568-1576, 2017.
APA
Li, J., Jin, E., Yu, L., Li, Y., Liu, N., Dong, Y. ... Li, X. (2017). Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis. Experimental and Therapeutic Medicine, 14, 1568-1576. https://doi.org/10.3892/etm.2017.4678
MLA
Li, J., Jin, E., Yu, L., Li, Y., Liu, N., Dong, Y., Li, X., Li, X."Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis". Experimental and Therapeutic Medicine 14.2 (2017): 1568-1576.
Chicago
Li, J., Jin, E., Yu, L., Li, Y., Liu, N., Dong, Y., Li, X., Li, X."Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1568-1576. https://doi.org/10.3892/etm.2017.4678