Association between HLA gene polymorphism and cutaneous adverse reactions caused by antiepileptic drugs

Zhang,Jingang; Li,Xinrui; Su,Yuanyuan; Sun,Min; Wang,Junbang; Hao,Yunhua

doi:10.3892/etm.2018.5801

Association between HLA gene polymorphism and cutaneous adverse reactions caused by antiepileptic drugs

Authors:
- Jingang Zhang
- Xinrui Li
- Yuanyuan Su
- Min Sun
- Junbang Wang
- Yunhua Hao
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Affiliations: Department of Neurology, Tianyou Hospital, Tongji University, Shanghai 200331, P.R. China, Department of Cardiology, Shandong Energy Zaozhuang Mining Group Central Hospital, Zaozhuang, Shandong 277800, P.R. China, Translational Stem Cell Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai 200331, P.R. China
Published online on: January 25, 2018 https://doi.org/10.3892/etm.2018.5801
Pages: 3399-3403
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The association between cutaneous adverse drug reactions (cADRs) caused by antiepileptic drugs (AEDs) and human leukocyte antigen‑A (HLA-A) and HLA-B genes in Chinese Han population in Shanghai was investigated. Through the case-control study, 30 child patients with AED-induced cADRs (cADRs group), 60 AED-tolerant child patients (AED-tolerant group) and 60 normal children not taking AEDs (normal group) were collected. The HLA-B*15:02 and HLA-A*31:01 genotypes were detected using the polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) probe method, and the correlation of HLA-B*15:02 and HLA-A*31:01 genes with the incidence of cADRs was analyzed. The positive rate of HLA-B*15:02 gene was 83.33% in the cADRs group, which was significantly increased compared with that in the AED-tolerant and normal groups (P<0.01). The positive rate of HLA-A*31:01 gene was 63.33% in the cADRs group, which was obviously increased compared with that in the AED-tolerant and normal groups (P<0.01). There were no significant differences in HLA-B*15:02 and HLA-A*31:01 genotypes between the AED-tolerant and normal groups (P>0.05). The results showed that HLA-B*15:02 and HLA-A*31:01 are significantly associated with cADRs in a Chinese Han population in Shanghai, suggesting that HLA-B*15:02 and HLA-A*31:01 genotypes should be detected in the application of AEDs.

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