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Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats

  • Authors:
    • Tolga Mercantepe
    • Deniz Unal
    • Levent Tümkaya
    • Zihni Acar Yazici
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize 53010, Turkey, Department of Histology and Embryology, Faculty of Medicine, Atatürk University, Erzurum 25000, Turkey, Department of Medical Microbiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize 53010, Turkey
    Copyright: © Mercantepe et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3404-3412
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    Published online on: January 31, 2018
       https://doi.org/10.3892/etm.2018.5819
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Abstract

Cisplatin is an effective antineoplastic drug that is usually used to treat a number of different types of cancer in the clinic. One of the most notable side effects of cisplatin use is infertility. The present study was designed to determine the non‑oxidative testicular effects caused by the use of cisplatin in rats. The rats were randomly allocated to the experimental groups. The untreated rats represented the control group (group I) and the treatment groups were as follows: cisplatin alone (group II), cisplatin+amifostine (group III), cisplatin+curcumin (group IV), and cisplatin+caffeic acid phenethyl ester (CAPE; group V). The present study observed that following cisplatin administration, the expression of nuclear factor‑κB (NF‑κβ)/p65, caspase‑3 and 8‑deoxyguanosine (8‑OHdG) increased in germinal epithelium and Leydig cells. However, the expression of these markers decreased in groups III‑V, most notably in the group treated with amifostine. cisplatin induced‑damage was countered by amifostine and curcumin. The results revealed that the activation of NF‑κB, caspase‑3 and 8‑OHdG had a significant role in cisplatin‑induced testicular toxicity. Thus, amifostine, curcumin and, to a lesser extent, CAPE have the potential for use as therapeutic adjuvants in cisplatin-induced testis injury.
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View References

1 

Sabanegh ES Jr and Ragheb AM: Male fertility after cancer. Urology. 73:225–231. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Schrier RW, Wang W, Poole B and Mitra A: Acute renal failure: Definitions, diagnosis, pathogenesis and therapy. J Clin Invest. 114:5–14. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Amin A and Hamza AA: Effects of roselle and ginger on cisplatin-induced reproductive toxicity in rats. Asian J Androl. 8:607–612. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Colpi GM, Contalbi GF, Nerva F, Sagone P and Piediferro G: Testicular function following chemo-radiotherapy. Eur J Obstet Gynecol Reprod Biol. 113 Suppl 1:S2–S6. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Cherry SM, Hunt PA and Hassold TJ: cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation. Mutat Res. 564:115–128. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Dohle GR: Male infertility in cancer patients: Review of the literature. Int J Urol. 17:327–331. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Agarwal A and Prabakaran SA: Mechanism, measurement and prevention of oxidative stress in male reproductive. physiology. 43:1–974. 2005.

8 

Tokatli F, Uzal C, Doganay L, Kocak Z, Kaya M, Ture M, Kurum T, Alkaya F, Karadag H and Kutlu K: The potential cardioprotective effects of amifostine in irradiated rats. Int J Radiat Oncol Biol Phys. 58:1228–1234. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Uzal C, Durmus-Altun G, Caloglu M, Ergülen A, Altaner S and Yigitbasi NO: The protective effect of amifostine on radiation-induced acute pulmonary toxicity: Detection by 99mTc-DTPA transalveolar clearances. Int J Radiat Oncol Biol Phys. 60:564–569. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Wasserman TH and Brizel DM: The role of amifostine as a radioprotector. Oncology (Williston Park). 15:1349–1354. 2001.PubMed/NCBI

11 

Choudhary D, Chandra D and Kale RK: Modulation of radioresponse of glyoxalase system by curcumin. J Ethnopharmacol. 64:1–7. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Devasena T, Rajasekaran KN and Menon VP: Bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione (a curcumin analog) ameliorates DMH-induced hepatic oxidative stress during colon carcinogenesis. Pharmacol Res. 46:39–45. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Pan MH, Huang TM and Lin JK: Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab Dispos. 27:486–494. 1999.PubMed/NCBI

14 

Uz E, Söğüt S, Sahin S, Var A, Ozyurt H, Güleç M and Akyol O: The protective role of caffeic acid phenethyl ester (CAPE) on testicular tissue after testicular torsion and detorsion. World J Urol. 20:264–270. 2002.PubMed/NCBI

15 

Grunberger D, Banerjee R, Eisinger K, Oltz EM, Efros L, Caldwell M, Estevez V and Nakanishi K: Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia. 44:230–232. 1988. View Article : Google Scholar : PubMed/NCBI

16 

Akyol S, Akbas A, Butun I, Toktas M, Ozyurt H, Sahin S and Akyol O: Caffeic acid phenethyl ester as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads. J Intercult Ethnopharmacol. 4:187–191. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Dilber Y, Inan S, Ercan GA and Sencan A: The role of CAPE in PI3K/AKT/mTOR activation and oxidative stress on testis torsion. Acta Histochem. 118:31–37. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Ogeturk M, Kus I, Colakoglu N, Zararsiz I, Ilhan N and Sarsilmaz M: Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats. J Ethnopharmacol. 97:273–280. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Kus I, Colakoglu N, Pekmez H, Seckin D, Ogeturk M and Sarsilmaz M: Protective effects of caffeic acid phenethyl ester (CAPE) on carbon tetrachloride-induced hepatotoxicity in rats. Acta Histochem. 106:289–297. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Tolba MF, Omar HA, Azab SS, Khalifa AE, Abdel-Naim AB and Abdel-Rahman SZ: Caffeic acid phenethyl ester: A review of its antioxidant activity, protective effects against ischemia-reperfusion injury and drug adverse reactions. Crit Rev Food Sci Nutr. 56:2183–2190. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Ciftci O, Beytur A, Cakir O, Gurbuz N and Vardi N: Comparison of reproductive toxicity caused by cisplatin and novel platinum-N-heterocyclic carbene complex in male rats. Basic Clin Pharmacol Toxicol. 109:328–333. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Boekelheide K: Mechanisms of toxic damage to spermatogenesis. J Natl Cancer Inst Monogr. 1–8. 2005.

23 

Meistrich ML, Finch M, Cunha MF, Hacker U and Au WW: Damaging effects of fourteen chemotherapeutic drugs on mouse testis cells damaging effects of fourteen chemotherapeutic drugs on mouse testis. 42:1–131. 1982.

24 

Jain KK: The handbook of neuroprotection. 2011. View Article : Google Scholar

25 

Ozgen SÇ, Dökmeci D, Akpolat M, Karadağ CH, Gündüz O, Erbaş H, Benian O, Uzal C and Turan FN: The protective effect of curcumin on ionizing radiation-induced cataractogenesis in rats. Balkan Med J. 29:358–363. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Kalkan Y, Kapakin KA, Kara A, Atabay T, Karadeniz A, Simsek N, Karakus E, Can I, Yildirim S, Ozkanlar S and Sengul E: Protective effect of panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate. J Mol Histol. 43:603–613. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Mercantepe T, Unal D, Selli J, Mercantepe F and Unal B: Protective effects of estrogen and bortezomib in kidney tissue of post-menopausal rats: An ultrastructural study. Ren Fail. 38:1129–1135. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Selli J, Unal D, Mercantepe F, Akaras N, Kabayel R, Unal B and Atilay H: Protective effects of beta glucan in brain tissues of post-menopausal rats: A histochemical and ultra-structural study. Gynecol Endocrinol. 32:234–239. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Bray F, Richiardi L, Ekbom A, Pukkala E, Cuninkova M and Møller H: Trends in testicular cancer incidence and mortality in 22 European countries: Continuing increases in incidence and declines in mortality. Int J Cancer. 118:3099–3111. 2006. View Article : Google Scholar : PubMed/NCBI

30 

International Agency for Research on Cancer: World cancer report 2008. 2008.

31 

Duale N, Lindeman B, Komada M, Olsen AK, Andreassen A, Soderlund EJ and Brunborg G: Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles. Mol Cancer. 6:532007. View Article : Google Scholar : PubMed/NCBI

32 

Mohammadnejad D, Abedelahi A, Soleimani-rad J, Mohammadi-roshandeh A, Rashtbar M and Azami A: Degenerative effect of cisplatin on testicular germinal epithelium. Adv Pharm Bull. 2:173–177. 2012.PubMed/NCBI

33 

Zhang X, Yamamoto N, Soramoto S and Takenaka I: cisplatin-induced germ cell apoptosis in mouse testes. Arch Androl. 46:43–49. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Aitken RJ: The amoroso lecture. The human spermatozoon-a cell in crisis? J Reprod Fertil. 115:1–7. 1999. View Article : Google Scholar : PubMed/NCBI

35 

Aitken RJ: Founders' lecture. Human spermatozoa: Fruits of creation, seeds of doubt. Reprod Fertil Dev. 16:655–664. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Peltola V, Huhtaniemi I and Ahotupa M: Antioxidant enzyme activity in the maturing rat testis. J Androl. 13:450–455. 1992.PubMed/NCBI

37 

Zini A and Schlegel PN: Catalase mRNA Expression in the male rat reproductive tract. J Androl. 17:473–480. 1996.PubMed/NCBI

38 

Al-Bader M and Kilarkaje N: Effects of bleomycin, etoposide and cisplatin treatment on Leydig cell structure and transcription of steroidogenic enzymes in rat testis. Eur J Pharmacol. 747:150–159. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Berger CC, Bokemeyer C, Schuppert F and Schmoll HJ: Endocrinological late effects after chemotherapy for testicular cancer. Br J Cancer. 73:1108–1114. 1996. View Article : Google Scholar : PubMed/NCBI

40 

Bieber AM, Marcon L, Hales BF and Robaire B: Effects of chemotherapeutic agents for testicular cancer on the male rat reproductive system, spermatozoa, and fertility. J Androl. 27:189–200. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Delbès G, Chan D, Pakarinen P, Trasler JM, Hales BF and Robaire B: Impact of the chemotherapy cocktail used to treat testicular cancer on the gene expression profile of germ cells from male Brown-Norway rats. Biol Reprod. 80:320–327. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Howell SJ and Shalet SM: Spermatogenesis after cancer treatment: Damage and recovery. J Natl Cancer Inst Monogr 12–17. 2005. View Article : Google Scholar

43 

Zirak MR, Rahimian R, Ghazi-Khansari M, Abbasi A, Razmi A, Mehr SE, Mousavizadeh K and Dehpour AR: Tropisetron attenuates cisplatin-induced nephrotoxicity in mice. Eur J Pharmacol. 738:222–229. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Pavkovic M, Riefke B and Ellinger-Ziegelbauer H: Urinary microRNA profiling for identification of biomarkers after cisplatin-induced kidney injury. Toxicology. 324:147–157. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Yang Y, Liu H, Liu F and Dong Z: Mitochondrial dysregulation and protection in cisplatin nephrotoxicity. Arch Toxicol. 88:1249–1256. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Nudell DM, Monoski MM and Lipshultz LI: Common medications and drugs: How they affect male fertility. Urol Clin North Am. 29:965–973. 2002. View Article : Google Scholar : PubMed/NCBI

47 

Ilbey YO, Ozbek E, Cekmen M, Simsek A, Otunctemur A and Somay A: Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: Mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. Hum Reprod. 24:1717–1725. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Nalesnik JG, Sabanegh ES Jr, Eng TY and Buchholz TA: Fertility in men after treatment for stage 1 and 2A seminoma. Am J Clin Oncol. 27:584–588. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Ozyurt B, Parlaktas BS, Ozyurt H, Aslan H, Ekici F and Atis O: A preliminary study of the levels of testis oxidative stress parameters after MK-801-induced experimental psychosis model: Protective effects of CAPE. Toxicology. 230:83–89. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Calaf GM, Echiburú-Chau C, Roy D, Chai Y, Wen G and Balajee AS: Protective role of curcumin in oxidative stress of breast cells. Oncol Rep. 26:1029–1035. 2011.PubMed/NCBI

51 

Zhou M, Fan C and Tian N: Effects of curcumin on the gene expression profile of L-02 cells. Biomed Rep. 3:519–526. 2015. View Article : Google Scholar : PubMed/NCBI

52 

He B, Wei W, Liu J, Xu Y and Zhao G: Synergistic anticancer effect of curcumin and chemotherapy regimen FP in human gastric cancer MGC-803 cells. Oncol Lett. 14:3387–3394. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Jiang S, Yan H, Fan D, Song J and Fan C: Multi-layer electrospun membrane mimicking tendon sheath for prevention of tendon adhesions. Int J Mol Sci. 16:6932–6944. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Wu S, Tao L, Wang JN, Xu ZQ, Wang J, Xue YJ, Huang KY, Lin JF, Li L and Ji KT: Amifostine pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis and oxidative stress. Oxid Med Cell Longev. 2017:41308242017. View Article : Google Scholar : PubMed/NCBI

55 

Chok MK, Conti M, Almolki A, Ferlicot S, Loric S, Dürrbach A, Benoît G, Droupy S and Eschwège P: Renoprotective potency of amifostine in rat renal ischaemiareperfusion. Nephrol Dial Transplant. 25:3845–3851. 2010. View Article : Google Scholar : PubMed/NCBI

56 

İkinci A, Mercantepe T, Unal D, Erol HS, Şahin A, Aslan A, Baş O, Erdem H, Sönmez OF, Kaya H and Odacı E: Morphological and antioxidant impairments in the spinal cord of male offspring rats following exposure to a continuous 900MHz electromagnetic field during early and mid-adolescence. J Chem Neuroanat. 75:99–104. 2016. View Article : Google Scholar : PubMed/NCBI

57 

Du Q, Hao C, Gou J, Li X, Zou K, He X and Li Z: Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats. Exp Ther Med. 11:1433–1440. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Severi-Aguiar GD, Pinto SJ, Capucho C, Oliveira CA, Diamante MA, Barbieri R, Predes FS and Dolder H: Chronic intake of green propolis negatively affecting the rat testis. Pharmacogn Res. 9:27–33. 2017. View Article : Google Scholar

59 

Chan D, Delbès G, Landry M, Robaire B and Trasler JM: Epigenetic alterations in sperm DNA associated with testicular cancer treatment. Toxicol Sci. 125:532–543. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Bhimani RS, Troll W, Grunberger D and Frenkel K: Inhibition of oxidative stress in HeLa cells by chemopreventive agents. Cancer Res. 53:4528–4533. 1993.PubMed/NCBI

61 

Ho C, Hsu YC, Lei CC, Mau SC, Shih YH and Lin CL: Curcumin Rescues Diabetic Renal Fibrosis by Targeting Superoxide-Mediated Wnt Signaling Pathways. Am J Med Sci. 351:286–295. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Jia J, Zhang L, Shi X, Wu M, Zhou X, Liu X and Huo T: SOD2 mediates amifostine-induced protection against glutamate in PC12 cells. Oxid Med Cell Longev. 2016:42024372016. View Article : Google Scholar : PubMed/NCBI

63 

Schwertheim S, Wein F, Lennartz K, Worm K, Schmid KW and Sheu-Grabellus SY: Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition and expression of differentiation genes in thyroid carcinoma cells. J Cancer Res Clin Oncol. 143:1143–1154. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mercantepe T, Unal D, Tümkaya L and Yazici ZA: Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats. Exp Ther Med 15: 3404-3412, 2018.
APA
Mercantepe, T., Unal, D., Tümkaya, L., & Yazici, Z.A. (2018). Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats. Experimental and Therapeutic Medicine, 15, 3404-3412. https://doi.org/10.3892/etm.2018.5819
MLA
Mercantepe, T., Unal, D., Tümkaya, L., Yazici, Z. A."Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats". Experimental and Therapeutic Medicine 15.4 (2018): 3404-3412.
Chicago
Mercantepe, T., Unal, D., Tümkaya, L., Yazici, Z. A."Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3404-3412. https://doi.org/10.3892/etm.2018.5819
Copy and paste a formatted citation
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Spandidos Publications style
Mercantepe T, Unal D, Tümkaya L and Yazici ZA: Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats. Exp Ther Med 15: 3404-3412, 2018.
APA
Mercantepe, T., Unal, D., Tümkaya, L., & Yazici, Z.A. (2018). Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats. Experimental and Therapeutic Medicine, 15, 3404-3412. https://doi.org/10.3892/etm.2018.5819
MLA
Mercantepe, T., Unal, D., Tümkaya, L., Yazici, Z. A."Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats". Experimental and Therapeutic Medicine 15.4 (2018): 3404-3412.
Chicago
Mercantepe, T., Unal, D., Tümkaya, L., Yazici, Z. A."Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3404-3412. https://doi.org/10.3892/etm.2018.5819
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