Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease

Tang,Zhaobin; Gu,Jingjing; Sun,Ping; Zhao,Jing; Zhao,Yonggang

doi:10.3892/etm.2018.5879

Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease

Authors:
- Zhaobin Tang
- Jingjing Gu
- Ping Sun
- Jing Zhao
- Yonggang Zhao
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Affiliations: Cardiology Second Ward, The First Hospital of Zibo, Zibo, Shandong 255200, P.R. China, Department of Pharmacy, The Fourth People's Hospital of Zibo, Zibo, Shandong 255200, P.R. China, Medical Record Management Section, The First Hospital of Zibo, Zibo, Shandong 255200, P.R. China
Published online on: February 20, 2018 https://doi.org/10.3892/etm.2018.5879
Pages: 3801-3808
Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bare-metal stents (BMS) and paclitaxel-eluting stent (PES) are frequently used in medicine for the treatment of coronary heart disease, with millions of patients treated worldwide. The protein-protein interactions (PPI) were adopted to construct the networks. The M-module algorithm was used to identify multiple differential modules. Gene Ontology enrichment and pathway enrichment analysis were performed to analyze characteristics of modules. With the PPI and microarray data, two differential co-expressed networks were constructed, module 1 indicating PES and module 2 indicating BMS, with the same genes but different edges. At a module connectivity dynamic score P-value cut-off of <0.05, module 1 was identified with 142 nodes and 460 edges and in the module 2, 73 nodes and 222 edges were identified. Significant biological processes and pathways were found different in the two modules. Through the two differential modules, we revealed the potential molecular changes induced by PES and BMS providing new insights into the underlying mechanisms in human left internal mammary arteries after inserted with a stent.

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