Open Access

Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase on cerebral ischemia in rats

Erratum in: /10.3892/etm.2020.8661

  • Authors:
    • Baoshan Li
    • Shouke Geng
    • Yuanli Dai
  • View Affiliations

  • Published online on: June 7, 2018     https://doi.org/10.3892/etm.2018.6271
  • Pages: 891-895
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase in the treatment of cerebral ischemia in rat model were investigated. Ninety rats were selected to establish cerebral ischemia model. Animal models were randomly divided into observation group and control group, with 45 rats in each group. Rats in observation group were treated with vascular intervention, and control group was treated with aspirin combined with defibrase. Peak systolic velocity (Vs) and end-diastolic velocity (Vd) were compared between two groups before and after 12 months of treatment. Therapeutic effects were compared before and after 6 months, and before and after 12 months of treatment. Vs and Vd of vascular lesions in observation group at 12 months were reduced after treatment, and were significantly lower than those in control group (p<0.05). After treatment, Vs and Vd in observation group were significantly reduced (p<0.05). There was no significant difference in Vs and Vd values between the groups before treatment (p>0.05). NDS scores in observation group were significantly lower than those in control group at 6 months and 1 year after treatment (p<0.05). There were no significant changes in NDS score at 6 and 12 months after treatment in control group compared with pretreatment group (p>0.05). NDS in observation group was significantly reduced at 6 and 12 months after treatment compared with pretreatment level (p<0.05). One year after treatment, incidence of cerebral infarction and transient ischemic attack and mortality in observation group were significantly lower than those in the control group (p<0.05). Intracranial vascular interventional therapy can achieve satisfactory outcomes in the treatment of cerebral ischemia, and can effectively promote nerve function recovery, and reduce the incidence of cerebrovascular diseases and mortality.
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August-2018
Volume 16 Issue 2

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Online ISSN:1792-1015

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Spandidos Publications style
Li B, Geng S and Dai Y: Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase on cerebral ischemia in rats Erratum in /10.3892/etm.2020.8661. Exp Ther Med 16: 891-895, 2018.
APA
Li, B., Geng, S., & Dai, Y. (2018). Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase on cerebral ischemia in rats Erratum in /10.3892/etm.2020.8661. Experimental and Therapeutic Medicine, 16, 891-895. https://doi.org/10.3892/etm.2018.6271
MLA
Li, B., Geng, S., Dai, Y."Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase on cerebral ischemia in rats Erratum in /10.3892/etm.2020.8661". Experimental and Therapeutic Medicine 16.2 (2018): 891-895.
Chicago
Li, B., Geng, S., Dai, Y."Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase on cerebral ischemia in rats Erratum in /10.3892/etm.2020.8661". Experimental and Therapeutic Medicine 16, no. 2 (2018): 891-895. https://doi.org/10.3892/etm.2018.6271