Concordance of 24‑h intraocular pressure curve in patients with untreated unilateral primary open‑angle glaucoma

Lin,Zhongjing; Huang,Shouyue; Huang,Ping; Li,Changwei; Chen,Zhenghua; Zhong,Yisheng

doi:10.3892/etm.2018.6315

Concordance of 24‑h intraocular pressure curve in patients with untreated unilateral primary open‑angle glaucoma

Authors:
- Zhongjing Lin
- Shouyue Huang
- Ping Huang
- Changwei Li
- Zhenghua Chen
- Yisheng Zhong
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Affiliations: Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, P.R. China, Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, P.R. China, Department of Ophthalmology, Suzhou Eye and ENT Hospital, Suzhou, Jiangsu 215006, P.R. China
Published online on: June 15, 2018 https://doi.org/10.3892/etm.2018.6315
Pages: 1461-1469

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Abstract

The present study aimed to assess the concordance of 24‑h intraocular pressure (IOP) curves between glaucomatous and contralateral eyes for patients with untreated unilateral primary open‑angle glaucoma (POAG). A total of 32 patients with unilateral POAG and 32 age‑matched normal subjects were enrolled. The IOP measurements were performed every 2 h over a 24‑h period. The concordance of the 24‑h IOP curves was assessed via the correlation coefficient (r), intraclass correlation coefficient (ICC) and repeated‑measures analysis of variance (ANOVA). No significant difference was identified between all IOPs, as well as the mean, peak and trough IOP or IOP fluctuations of the paired eyes in the two groups. The strength of association of all IOPs was moderate in the glaucoma group (r, 0.752‑0.867) and the normal controls (r, 0.625‑0.873). IOP readings at each time‑point indicated a high agreement in the glaucoma group (ICC, 0.857‑0.929) and the normal controls (ICC, 0.768‑0.932). Repeated‑measures ANOVA indicated that the 24‑h IOP curves of the paired eyes had parallel profiles in the two study groups (P=0.837 and P=0.897, respectively). The glaucoma patients had significantly higher proportions of all IOPs displaying absolute differences of ≥2 and ≥3 mmHg (46.09 vs. 35.68%, P<0.001; 29.69 vs. 12.50%, P<0.001, respectively). In conclusion, the 24‑h IOP curves of the paired eyes had parallel profiles in unilateral glaucoma patients and normal subjects. However, unilateral glaucoma patients had a significantly larger proportion of IOP differences of ≥2 and ≥3 mmHg.

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1	Tham YC, Li X, Wong TY, Quigley HA, Aung T and Cheng CY: Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology. 121:2081–2090. 2014. View Article : Google Scholar : PubMed/NCBI
2	Weinreb RN and Khaw PT: Primary open-angle glaucoma. Lancet. 363:1711–1720. 2004. View Article : Google Scholar : PubMed/NCBI
3	Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B and Hussein M: Early Manifest Glaucoma Trial Group, Reduction of intraocular pressure and glaucoma progression: Results from the early manifest glaucoma trial. Arch Ophthalmol. 120:1268–1279. 2002. View Article : Google Scholar : PubMed/NCBI
4	Liu JH, Sit AJ and Weinreb RN: Variation of 24-h intraocular pressure in healthy individuals: Right eye versus left eye. Ophthalmology. 112:1670–1675. 2005. View Article : Google Scholar : PubMed/NCBI
5	Lee AJ, Rochtchina E and Mitchell P: Intraocular pressure asymmetry and undiagnosed open-angle glaucoma in an older population. Am J Ophthalmol. 137:380–382. 2004. View Article : Google Scholar : PubMed/NCBI
6	Realini T, Barber L and Burton D: Frequency of asymmetric intraocular pressure fluctuations among patients with and without glaucoma. Ophthalmology. 109:1367–1371. 2002. View Article : Google Scholar : PubMed/NCBI
7	Levine RA, Demirel S, Fan J, Keltner JL, Johnson CA and Kass MA: Ocular Hypertension Treatment Study Group, Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study. Invest Ophthalmol Vis Sci. 47:3896–3903. 2006. View Article : Google Scholar : PubMed/NCBI
8	Dinn RB, Zimmerman MB, Shuba LM, Doan AP, Maley MK, Greenlee EC, Alward WL and Kwon YH: Concordance of diurnal intraocular pressure between fellow eyes in primary open-angle glaucoma. Ophthalmology. 114:915–920. 2007. View Article : Google Scholar : PubMed/NCBI
9	Sit AJ, Liu JH and Weinreb RN: Asymmetry of right versus left intraocular pressures over 24 hs in glaucoma patients. Ophthalmology. 113:425–430. 2006. View Article : Google Scholar : PubMed/NCBI
10	Liu JH and Weinreb RN: Asymmetry of habitual 24-h intraocular pressure rhythm in glaucoma patients. Invest Ophthalmol Vis Sci. 55:7398–7402. 2014. View Article : Google Scholar : PubMed/NCBI
11	Realini T, Weinreb RN and Wisniewski S: Short-term repeatability of diurnal intraocular pressure patterns in glaucomatous individuals. Ophthalmology. 118:47–51. 2011. View Article : Google Scholar : PubMed/NCBI
12	Aptel F, Lesoin A, Chiquet C, Aryal-Charles N, Noel C and Romanet JP: Long-term reproducibility of diurnal intraocular pressure patterns in patients with glaucoma. Ophthalmology. 121:1998–2003. 2014. View Article : Google Scholar : PubMed/NCBI
13	Prum BE Jr, Rosenberg LF, Gedde SJ, Mansberger SL, Stein JD, Moroi SE, Herndon LW Jr, Lim MC and Williams RD: Primary open-angle glaucoma preferred practice pattern(^®) guidelines. Ophthalmology. 123:P112–P151. 2016. View Article : Google Scholar : PubMed/NCBI
14	Bamdad S, Beigi V and Sedaghat MR: Sensitivity and specificity of Swedish interactive threshold algorithm and standard full threshold perimetry in primary open-angle glaucoma. Med Hypothesis Discov Innov Ophthalmol. 6:125–129. 2017.PubMed/NCBI
15	Landis JR and Koch GG: The measurement of observer agreement for categorical data. Biometrics. 33:159–174. 1977. View Article : Google Scholar : PubMed/NCBI
16	Williams AL, Gatla S, Leiby BE, Fahmy I, Biswas A, de Barros DM, Ramakrishnan R, Bhardwaj S, Wright C, Dubey S, et al: The value of intraocular pressure asymmetry in diagnosing glaucoma. J Glaucoma. 22:215–218. 2013. View Article : Google Scholar : PubMed/NCBI
17	Chiseliţă D, Moţoc I and Danielescu C: Concordance of nictemeral IOP variations between fellow eyes in glaucoma and non glaucoma patients. Oftalmologia. 52:102–109. 2008.PubMed/NCBI
18	Plange N, Kaup M, Arend O and Remky A: Asymmetric visual field loss and retrobulbar haemodynamics in primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol. 244:978–983. 2006. View Article : Google Scholar : PubMed/NCBI
19	Brubaker RF: Targeting outflow facility in glaucoma management. Surv Ophthalmol. 48 Suppl 1:S17–S20. 2003. View Article : Google Scholar : PubMed/NCBI
20	Stamer WD and Acott TS: Current understanding of conventional outflow dysfunction in glaucoma. Curr Opin Ophthalmol. 23:135–143. 2012. View Article : Google Scholar : PubMed/NCBI
21	Cook JA, Botello AP, Elders A, Fathi Ali A, Azuara-Blanco A, Fraser C, McCormack K and Margaret Burr J: Surveillance of Ocular Hypertension Study Group, Systematic review of the agreement of tonometers with Goldmann applanation tonometry. Ophthalmology. 119:1552–1557. 2012. View Article : Google Scholar : PubMed/NCBI
22	Yilmaz I, Altan C, Aygit ED, Alagoz C, Baz O, Ahmet S, Urvasizoglu S, Yasa D and Demirok A: Comparison of three methods of tonometry in normal subjects: Goldmann applanation tonometer, non-contact airpuff tonometer and Tono-Pen XL. Clin Ophthalmol. 8:1069–1074. 2014. View Article : Google Scholar : PubMed/NCBI
23	Fogagnolo P, Capizzi F, Orzalesi N, Figus M, Ferreras A and Rossetti L: Can mean central corneal thickness and its 24-h fluctuation influence fluctuation of intraocular pressure? J Glaucoma. 19:418–423. 2009. View Article : Google Scholar
24	Myrowitz EH, Kouzis AC and O'Brien TP: High interocular corneal symmetry in average simulated keratometry, central corneal thickness and posterior elevation. Optom Vis Sci. 82:428–431. 2005. View Article : Google Scholar : PubMed/NCBI
25	Bagga H, Liu JH and Weinreb RN: Intraocular pressure measurements throughout the 24 h. Curr Opin Ophthalmol. 20:79–83. 2009. View Article : Google Scholar : PubMed/NCBI
26	Lee JY, Yoo C, Jung JH, Hwang YH and Kim YY: The effect of lateral decubitus position on intraocular pressure in healthy young subjects. Acta Ophthalmol. 90:e68–e72. 2012. View Article : Google Scholar : PubMed/NCBI
27	Lee JY, Yoo C and Kim YY: The effect of lateral decubitus position on intraocular pressure in patients with untreated open-angle glaucoma. Am J Ophthalmol. 155:329–335.e2. 2013. View Article : Google Scholar : PubMed/NCBI
28	Lee TE, Yoo C and Kim YY: Effects of different sleeping postures on intraocular pressure and ocular perfusion pressure in healthy young subjects. Ophthalmology. 120:1565–1570. 2013. View Article : Google Scholar : PubMed/NCBI
29	Malihi M and Sit AJ: Effect of head and body position on intraocular pressure. Ophthalmology. 119:987–991. 2012. View Article : Google Scholar : PubMed/NCBI
30	Mansouri K: The road ahead to continuous 24-h intraocular pressure monitoring in glaucoma. J Ophthalmic Vis Res. 9:260–268. 2014.PubMed/NCBI
31	Mansouri K, Medeiros FA, Tafreshi A and Weinreb RN: Continuous 24-h monitoring of intraocular pressure patterns with a contact lens sensor: Safety, tolerability and reproducibility in patients with glaucoma. Arch Ophthalmol. 130:1534–1539. 2012. View Article : Google Scholar
32	Mottet B, Aptel F, Romanet JP, Hubanova R, Pépin JL and Chiquet C: 24-h intraocular pressure rhythm in young healthy subjects evaluated with continuous monitoring using a contact lens sensor. JAMA Ophthalmol. 131:1507–1516. 2013. View Article : Google Scholar : PubMed/NCBI