Chronic pulmonary complications associated with toxic epidermal necrolysis: A case report and literature review

Xu,Nuo; Chen,Xuehua; Wu,Shengdi; Ye,Maosong; Zhang,Meiling; Tong,Lin; Zhu,Xiaodan; Liu,Jie; Hu,Feifei; Bai,Chunxue

doi:10.3892/etm.2018.6357

Chronic pulmonary complications associated with toxic epidermal necrolysis: A case report and literature review

Authors:
- Nuo Xu
- Xuehua Chen
- Shengdi Wu
- Maosong Ye
- Meiling Zhang
- Lin Tong
- Xiaodan Zhu
- Jie Liu
- Feifei Hu
- Chunxue Bai
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Affiliations: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
Published online on: June 27, 2018 https://doi.org/10.3892/etm.2018.6357
Pages: 2027-2031

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Abstract

Patients with toxic epidermal necrolysis (TEN) are known to experience various complications. Although pulmonary complications are commonly observed, they typically manifest in an acute form. By contrast, chronic complications are quite rare, and little is known with regard to their incidences or clinical manifestations. The present study reports the case of a 29‑year‑old female patient who suffered from TEN. At the onset of the disease, the patient exhibited no pulmonary impairment; however, 1 month after recovering from TEN, the patient developed severe obstruction and a mild diffusion defect. A diagnosis of bronchiolitis obliterans was determined, and the patient was treated with antibiotics, inhaled corticosteroids, anticholinergic agents, and bronchodilators. At the last follow‑up, the patient was alive, but with a stable airway obstruction.

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