Open Access

Naringin promotes cellular chemokine synthesis and potentiates mesenchymal stromal cell migration via the Ras signaling pathway

  • Authors:
    • Feng Lin
    • Yuan Zhu
    • Gangfeng Hu
  • View Affiliations

  • Published online on: August 21, 2018     https://doi.org/10.3892/etm.2018.6634
  • Pages: 3504-3510
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Directional migration of mesenchymal stem cells (MSCs) is known to serve roles in bone fracture healing. Naringin is a traditional medicine used in China to treat bone injury and has been confirmed to act as a chemoattractant to MSCs. In the present study, the secretion of chemokines and stimulation of relevant signaling pathways by naringin were detected to determine the molecular mechanism of naringin‑induced MSC migration. In these experiments, Quantibody® arrays were used to detect chemokines secreted by MSCs with or without the addition of naringin. The results revealed differential naringin‑induced chemokine secretion of C‑X‑C motif chemokine (CXCL)5, CXCL6 and C‑C motif chemokine 20. Furthermore, the Ras signaling pathway was markedly activated in the naringin‑treated groups, suggesting that naringin may enhance the migrational ability of MSCs via Ras activation. Furthermore, naringin was able to promote the secretion of various chemokines derived from MSCs, which would, in turn, increase the mobility of MSCs. The aim of the present study was to provide novel candidate agents for clinical orthopedics and theoretical basis for the future improvement of adjunctive medication for bone fracture healing.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lin F, Zhu Y and Hu G: Naringin promotes cellular chemokine synthesis and potentiates mesenchymal stromal cell migration via the Ras signaling pathway. Exp Ther Med 16: 3504-3510, 2018.
APA
Lin, F., Zhu, Y., & Hu, G. (2018). Naringin promotes cellular chemokine synthesis and potentiates mesenchymal stromal cell migration via the Ras signaling pathway. Experimental and Therapeutic Medicine, 16, 3504-3510. https://doi.org/10.3892/etm.2018.6634
MLA
Lin, F., Zhu, Y., Hu, G."Naringin promotes cellular chemokine synthesis and potentiates mesenchymal stromal cell migration via the Ras signaling pathway". Experimental and Therapeutic Medicine 16.4 (2018): 3504-3510.
Chicago
Lin, F., Zhu, Y., Hu, G."Naringin promotes cellular chemokine synthesis and potentiates mesenchymal stromal cell migration via the Ras signaling pathway". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3504-3510. https://doi.org/10.3892/etm.2018.6634