Open Access

Baseline serum miR‑125b levels predict virologic response to nucleos(t)ide analogue treatment in patients with HBeAg‑positive chronic hepatitis B

  • Authors:
    • Pu Zhou
    • Minhui Dong
    • Jinyu Wang
    • Fahong Li
    • Jiming Zhang
    • Jingwen Gu
  • View Affiliations

  • Published online on: September 3, 2018     https://doi.org/10.3892/etm.2018.6685
  • Pages: 3805-3812
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the predictive value of baseline serum microRNA (miRNA)-125b for nucleos(t)ide analogues (NAs) in patients with chronic hepatitis B (CHB). A total of 66 patients with Be antigen (HBeAg)‑positive CHB received NAs therapy for 144 weeks. Serum miRNA‑125b levels were measured at the baseline, while hepatitis B virus (HBV) DNA, hepatitis B surface antigen (HBsAg) and alanine aminotransferase (ALT) levels were measured throughout treatment. Stepwise logistic regression analysis was performed to identify predictors of treatment response. The results indicated that baseline serum miR‑125b (OR=4.377; P=0.006), HBsAg (OR=0.120; P=0.010), ALT >5x upper limit of normal (ULN; OR=11.726; P=0.018) and undetectable HBV DNA at week 24 (OR=7.828; P=0.021) were independent predictors of complete response (CR) at 144 weeks (CR is defined as HBV DNA <500 IU/ml and HBeAg seroconversion). The baseline serum miRNA‑125b combined with baseline HBsAg level yielded an area under the receiver‑operating curve of 0.852 in discriminating CR and non‑CR at 144 week. The combination of baseline miRNA‑125b ≥1.7 and ALT >5x ULN had a positive predictive value 80% for CR at 144 weeks. The combination of baseline miRNA‑125b ≥1.7 and HbsAg ≤4.4 (log10 IU/ml) had a negative predictive value of CR at 144 weeks of 100%. Together, these results suggest that baseline miRNA‑125b is a reliable predictor of HBeAg seroconversion following NAs treatment. The present study may be used as a basis for the use of baseline miRNA‑125b to optimize treatment prior to NAs therapy.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou P, Dong M, Wang J, Li F, Zhang J and Gu J: Baseline serum miR‑125b levels predict virologic response to nucleos(t)ide analogue treatment in patients with HBeAg‑positive chronic hepatitis B. Exp Ther Med 16: 3805-3812, 2018.
APA
Zhou, P., Dong, M., Wang, J., Li, F., Zhang, J., & Gu, J. (2018). Baseline serum miR‑125b levels predict virologic response to nucleos(t)ide analogue treatment in patients with HBeAg‑positive chronic hepatitis B. Experimental and Therapeutic Medicine, 16, 3805-3812. https://doi.org/10.3892/etm.2018.6685
MLA
Zhou, P., Dong, M., Wang, J., Li, F., Zhang, J., Gu, J."Baseline serum miR‑125b levels predict virologic response to nucleos(t)ide analogue treatment in patients with HBeAg‑positive chronic hepatitis B". Experimental and Therapeutic Medicine 16.5 (2018): 3805-3812.
Chicago
Zhou, P., Dong, M., Wang, J., Li, F., Zhang, J., Gu, J."Baseline serum miR‑125b levels predict virologic response to nucleos(t)ide analogue treatment in patients with HBeAg‑positive chronic hepatitis B". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3805-3812. https://doi.org/10.3892/etm.2018.6685