Open Access

Axon guidance pathway genes are associated with schizophrenia risk

  • Authors:
    • Zhichao Wang
    • Ping Li
    • Tong Wu
    • Shuangyue Zhu
    • Libin Deng
    • Guangcheng Cui
  • View Affiliations

  • Published online on: September 19, 2018     https://doi.org/10.3892/etm.2018.6781
  • Pages: 4519-4526
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, we analyzed schizophre­nia (SCZ)‑related genome‑wide association studies (GWAS) to identify genes and pathways associated with SCZ. We identified 1,098 common genes (1,098/9,468) and 20 shared KEGG pathways (both P<0.01) by integrating candidate genes from the European and American SCZ‑related GWAS. The pathways related to axon guidance, long term potentiation and arrhythmogenic right ventricular cardiomyopathy (ARVC) were highly significant (P<10‑3). Moreover, 15 axon guidance pathway‑related genes were associated with SCZ. The association between axon guidance pathway genes and SCZ was validated by a two‑stage case‑control study on Shandong migrants in northeastern China. Moreover, individuals with the rs9944880 TT polymorphism in the deleted in colorectal cancer (DCC) gene were associated with SCZ. These findings indicate that the axon guidance pathway genes and the rs9944880 SNP in DCC gene are associated with SCZ pathogenesis.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang Z, Li P, Wu T, Zhu S, Deng L and Cui G: Axon guidance pathway genes are associated with schizophrenia risk. Exp Ther Med 16: 4519-4526, 2018.
APA
Wang, Z., Li, P., Wu, T., Zhu, S., Deng, L., & Cui, G. (2018). Axon guidance pathway genes are associated with schizophrenia risk. Experimental and Therapeutic Medicine, 16, 4519-4526. https://doi.org/10.3892/etm.2018.6781
MLA
Wang, Z., Li, P., Wu, T., Zhu, S., Deng, L., Cui, G."Axon guidance pathway genes are associated with schizophrenia risk". Experimental and Therapeutic Medicine 16.6 (2018): 4519-4526.
Chicago
Wang, Z., Li, P., Wu, T., Zhu, S., Deng, L., Cui, G."Axon guidance pathway genes are associated with schizophrenia risk". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4519-4526. https://doi.org/10.3892/etm.2018.6781