Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency

Liu,Cewen; Li,Hui

doi:10.3892/etm.2018.6916

Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency

Authors:
- Cewen Liu
- Hui Li
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Affiliations: Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
Published online on: November 1, 2018 https://doi.org/10.3892/etm.2018.6916
Pages: 368-372
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Correlation of the severity of chronic kidney disease (CKD) with serum inflammation, osteoporosis and vitamin D deficiency was investigated. A total of 78 patients suffering from CKD who presented to the Union Hospital from December 2015 to December 2017 were selected randomly and divided into three groups based on the severity of the disease. Comparisons of interleukin‑6 (IL‑6), C‑reactive protein (CRP), tumor necrosis factor‑α (TNF‑α), indicators of osteoporosis [serum phosphate, serum calcium and bone mineral density (BMD)], content of 25(OH)D, serum sodium, serum potassium and BUN were conducted among groups. The correlation of in vivo creatinine (Cr) with C‑reactive protein (CRP), TNF-α, BMD and vitamin D deficiency were analyzed. With the aggravation of illness, IL‑6, CRP, TNF‑α, serum phosphate, serum sodium, serum potassium and blood urea nitrogen (BUN) were increased gradually, while serum calcium, BMD and vitamin D were decreased significantly (P<0.05). The content of Cr in patients suffering from osteoporosis was significantly higher than that in normal group (P<0.05). The Cr of patients in the group with abnormal CRP was significantly higher than that with normal CRP (P<0.05). Analysis showed that there is positive correlation between Cr and CRP (r=0.6961, P<0.001), as well as between Cr and TNF‑α (r=0.8969, P<0.001); and negative correlation between Cr and BMD (r=0.5472, P<0.001), and between Cr and 25(OH)D (r=0.4733, P<0.001). The severity of CKD is correlated with serum inflammation, osteoporosis and vitamin D deficiency. The higher the severity of the illness, the worse the condition of osteoporosis will be.

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