Two successive cases of fetal harlequin ichthyosis: A case report

  • Authors:
    • Qianhong Liang
    • Fu Xiong
    • Xuankun Liang
    • Dongming Zheng
    • Shuguang Su
    • Yunjie Wen
    • Xiaodan Wang
  • View Affiliations

  • Published online on: November 2, 2018     https://doi.org/10.3892/etm.2018.6917
  • Pages: 449-452
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Abstract

Harlequin ichthyosis (HI) is a genetic skin disorder characterized by thickening and splitting of the skin. In fetuses presenting with the disorder, the mortality rate is markedly high. A number of fetal HI cases have been documented. The present study reports a case of a pregnant woman who underwent two successive pregnancies at the ages of 35 and 36, respectively, with both fetuses presenting with HI. The first fetus was delivered alive though succumbed shortly after birth, while the second fetus was stillborn and birthed by induced labor. The fetuses exhibited typical features of fetal HI, including thick, platelike scaling and fissuring, which act as a nidus for infection. The present study is the first to report two cases of fetal HI from successive pregnancies in the same woman. Improved understanding of the genetic basis of HI indicates that genetic screening for candidate gene mutations related to HI, particularly mutations in the adenosine triphosphate binding‑cassette transporter ABCA12, may prove beneficial in prenatal diagnosis. Establishing methods for early diagnosis of fetal HI may reduce the physical and mental distress to parents and relatives.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liang Q, Xiong F, Liang X, Zheng D, Su S, Wen Y and Wang X: Two successive cases of fetal harlequin ichthyosis: A case report. Exp Ther Med 17: 449-452, 2019.
APA
Liang, Q., Xiong, F., Liang, X., Zheng, D., Su, S., Wen, Y., & Wang, X. (2019). Two successive cases of fetal harlequin ichthyosis: A case report. Experimental and Therapeutic Medicine, 17, 449-452. https://doi.org/10.3892/etm.2018.6917
MLA
Liang, Q., Xiong, F., Liang, X., Zheng, D., Su, S., Wen, Y., Wang, X."Two successive cases of fetal harlequin ichthyosis: A case report". Experimental and Therapeutic Medicine 17.1 (2019): 449-452.
Chicago
Liang, Q., Xiong, F., Liang, X., Zheng, D., Su, S., Wen, Y., Wang, X."Two successive cases of fetal harlequin ichthyosis: A case report". Experimental and Therapeutic Medicine 17, no. 1 (2019): 449-452. https://doi.org/10.3892/etm.2018.6917