Open Access

Role of miR‑155 in immune regulation and its relevance in oral lichen planus (Review)

  • Authors:
    • Yan Tao
    • Ruixue Ai
    • Yilong Hao
    • Lu Jiang
    • Hongxia Dan
    • Ning Ji
    • Xin Zeng
    • Yu Zhou
    • Qianming Chen
  • View Affiliations

  • Published online on: November 27, 2018     https://doi.org/10.3892/etm.2018.7019
  • Pages: 575-586
  • Copyright: © Tao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oral lichen planus (OLP) is a chronic mucosal inflammatory disease. The World Health Organization has described it as a potentially malignant condition. The pathogenesis of OLP remains to be fully elucidated, but extensive evidence suggests that immunologic and inflammatory factors have important roles. MicroRNAs (miRs), which are small non‑coding RNAs, have been reported to be involved in OLP. In particular, miR‑155 is significantly upregulated in patients with OLP. miR‑155 has numerous functions and is closely linked to inflammation and immune system regulation. However, in‑depth studies of the mechanisms via which miR‑155 is involved in OLP are currently insufficient. Considering the close association between miR‑155 and immune regulation as well as the importance of immune factors in OLP, the role of miR‑155 in the immune system was herein summarized with a focus on OLP. The present review provides a basis for further study of the molecular mechanisms underlying the development and progression of OLP.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tao Y, Ai R, Hao Y, Jiang L, Dan H, Ji N, Zeng X, Zhou Y and Chen Q: Role of miR‑155 in immune regulation and its relevance in oral lichen planus (Review). Exp Ther Med 17: 575-586, 2019.
APA
Tao, Y., Ai, R., Hao, Y., Jiang, L., Dan, H., Ji, N. ... Chen, Q. (2019). Role of miR‑155 in immune regulation and its relevance in oral lichen planus (Review). Experimental and Therapeutic Medicine, 17, 575-586. https://doi.org/10.3892/etm.2018.7019
MLA
Tao, Y., Ai, R., Hao, Y., Jiang, L., Dan, H., Ji, N., Zeng, X., Zhou, Y., Chen, Q."Role of miR‑155 in immune regulation and its relevance in oral lichen planus (Review)". Experimental and Therapeutic Medicine 17.1 (2019): 575-586.
Chicago
Tao, Y., Ai, R., Hao, Y., Jiang, L., Dan, H., Ji, N., Zeng, X., Zhou, Y., Chen, Q."Role of miR‑155 in immune regulation and its relevance in oral lichen planus (Review)". Experimental and Therapeutic Medicine 17, no. 1 (2019): 575-586. https://doi.org/10.3892/etm.2018.7019