A case‑control study of the relationship between visceral fat and development of uterine fibroids
- Authors:
- Kejuan Sun
- Ying Xie
- Na Zhao
- Zengning Li
View Affiliations
Affiliations: Department of Nursing, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China, Department of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China, Department of Gynecology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China
- Published online on: May 10, 2019 https://doi.org/10.3892/etm.2019.7575
-
Pages:
404-410
-
Copyright: © Sun
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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Abstract
Relationship between visceral fat and development of uterine fibroids in adult women was investigated. A total of 89 patients with uterine fibroids treated in the First Hospital of Hebei Medical University from April 2016 to April 2018 were enrolled. Another 81 healthy women without uterine fibroids receiving physical examination in the same period were selected as the control group. Self‑designed questionnaires were used to investigate the general conditions of the subjects, bioelectrical impedance analysis was employed to analyze obesity‑related indicators, and their correlation with the risk of uterine fibroids was explored. Visceral fat area (VFA), body mass index (BMI), body fat percentage, waist circumference, waist‑height ratio and waist‑hip ratio were positively correlated with the incidence rate of uterine fibroids, and the odds ratio (OR), 95% confidence interval (CI) was 3.910 (2.029, 7.536), 2.716 (1.444, 5.110), 4.335 (1.507, 12.469), 2.881 (1.531, 5.423), 3.837 (1.914, 7.692) and 7.707 (3.501, 16.965), respectively. VFA and body fat percentage were correlated with the size of uterine fibroids, but the correlations were relatively weak. With the increase in the VFA, BMI, waist circumference, waist‑height ratio, and waist‑hip ratio, the risk of uterine fibroids was elevated. The BMI, VFA and waist circumference of patients with uterine fibroids were gradually increased with increasing age, showing statistically significant differences. Increased body fat (especially abdominal visceral fat) is able to enhance the risk of uterine fibroids. For perimenopausal women, the waist‑hip ratio measured can be used as an indicator screening high‑risk groups of uterine fibroids. This method is simple, easy and inexpensive. At the same time, providing nutrition guidance and changing diet and exercise habits are important measures to prevent the development of uterine fibroids.
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