Use of contrast‑enhanced computed tomographic imaging to diagnose and evaluate Behçet's disease with vascular complications

Qi,Lin; Cai,Jianfei; Mao,Dingbiao; Wang,Ming; Ge,Xiaojun; Wu,Weilan; Jin,Xiu; Li,Cheng; Hua,Yanqing; Li,Ming

doi:10.3892/etm.2019.8088

Use of contrast‑enhanced computed tomographic imaging to diagnose and evaluate Behçet's disease with vascular complications

Authors:
- Lin Qi
- Jianfei Cai
- Dingbiao Mao
- Ming Wang
- Xiaojun Ge
- Weilan Wu
- Xiu Jin
- Cheng Li
- Yanqing Hua
- Ming Li
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Affiliations: Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China, Department of Rheumatology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China
Published online on: October 8, 2019 https://doi.org/10.3892/etm.2019.8088
Pages: 4265-4272
Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, multi‑slice CT results of patients with Behçet's disease (BD) and vascular complications were retrospectively evaluated. From January 2016 to May 2018, 45 of 361 patients with BD were diagnosed with vascular involvement. The clinical background, laboratory parameters and response to therapy of those patients were assessed. The following characteristics of vascular aneurysms were analyzed: Maximum diameter, length, wall thickness, borders, luminal changes, mural thrombus, cystic change of the vessel walls, asymmetric bulging of the right part of the aortic wall (RP type) and calcific plaques. The 45 BD patients analyzed included 37 males and 8 females with a median age of 40 years (30‑49 years). Significant differences were observed among genders regarding age, ocular disorders and digestive‑tract ulceration. A total of 42 aneurysms were identified with a mean diameter of 43 mm. Most aneurysmal walls (88%) were homogeneously enhanced on contrast‑enhanced CT. Comparison of groups classified by aortic and larger arterial aneurysms indicated that aneurysms occurring in the aorta were more likely to form a mural thrombus, have a thicker wall (P<0.001) and unclear borders (P=0.036), to be of the RP type (P=0.003) and have a longer extension (P=0.001) compared with those in larger arteries. Unclear border of the aneurysmal wall was the only radiologic predictor correlated with an elevated erythrocyte sedimentation rate (P<0.001). In conclusion, characteristic CT imaging features of aneurysms may help to diagnose vascular involvement of BD and assess its severity, particularly in the absence of the classical clinical manifestations.

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