Potential benefits of garlic and other dietary supplements for the management of hypertension (Review)
- Authors:
- Toshiaki Matsutomo
-
Affiliations: Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Akitakata-shi, Hiroshima 739-1195, Japan - Published online on: December 27, 2019 https://doi.org/10.3892/etm.2019.8375
- Pages: 1479-1484
-
Copyright: © Matsutomo . This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
GBD 2013 Risk Factors Collaborators, ; Forouzanfar MH, Alexander L, Anderson HR, Bachman VF, Biryukov S, Brauer M, Burnett R, Casey D, Coates MM, et al: Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risk factors or clusters of risks in 188 countries, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 386:2287–2323. 2015. View Article : Google Scholar : PubMed/NCBI | |
Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK and He J: Global burden of hypertension: Analysis of worldwide data. Lancet. 365:217–223. 2005. View Article : Google Scholar : PubMed/NCBI | |
Lafeber M, Spiering W, Visseren FL and Grobbee DE: Multifactorial prevention of cardiovascular disease in patients with hypertension: The cardiovascular polypill. Curr Hypertens Rep. 18:402016. View Article : Google Scholar : PubMed/NCBI | |
Park C, Wang G, Durthaler JM and Fang J: Cost-effectiveness analyses of antihypertensive medicines: A systematic review. Am J Prev Med. 53:S131–S142. 2017. View Article : Google Scholar : PubMed/NCBI | |
Garjón J, Saiz LC, Azparren A, Elizondo JJ, Gaminde I, Ariz MJ and Erviti J and Erviti J: First-line combination therapy versus first-line monotherapy for primary hypertension. Cochrane Database Syst Rev. 1:CD0103162017.PubMed/NCBI | |
Oparil S, Acelajado MC, Bakris GL, Berlowitz DR, Cífková R, Dominiczak AF, Grassi G, Jordan J, Poulter NR, Rodgers A, et al: Hypertension. Nat Rev Dis Primers. 4:180142018. View Article : Google Scholar : PubMed/NCBI | |
Cho J, Kim C, Kang DR and Park JB: Hyperuricemia and uncontrolled hypertension in treated hypertensive patients: K-MetS Study. Medicine (Baltimore). 95:e41772016. View Article : Google Scholar : PubMed/NCBI | |
Chow CK, Teo KK, Rangarajan S, Islam S, Gupta R, Avezum A, Bahonar A, Chifamba J, Dagenais G, Diaz R, et al PURE (Prospective Urban Rural Epidemiology) Study investigators, : Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA. 310:959–968. 2013. View Article : Google Scholar : PubMed/NCBI | |
Fryar CD, Ostchega Y, Hales CM, Zhang G and Kruszon-Moran D: Hypertension prevalence and control among adults: United States, 2015–2016. NCHS Data Brief. 289:1–8. 2017. | |
National Institutes of Health (NIH), . National Center for Complementary and Integrative Health (NCCIH): Complementary, Alternative, or Integrative Health: What's In a Name? https://nccih.nih.gov/health/integrative-health | |
Afolayan AJ and Wintola OA: Dietary supplements in the management of hypertension and diabetes - a review. Afr J Tradit Complement Altern Med. 11:248–258. 2014. View Article : Google Scholar : PubMed/NCBI | |
Upadrasta A and Madempudi RS: Probiotics and blood pressure: Current insights. Integr Blood Press Control. 9:33–42. 2016.PubMed/NCBI | |
Santos-Ocaña C, Do TQ, Padilla S, Navas P and Clarke CF: Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants. J Biol Chem. 277:10973–10981. 2002. View Article : Google Scholar : PubMed/NCBI | |
Yamagami T, Shibata N and Folkers K: Bioenergetics in clinical medicine. Studies on coenzyme Q10 and essential hypertension. Res Commun Chem Pathol Pharmacol. 11:273–288. 1975.PubMed/NCBI | |
Langsjoen PH and Langsjoen AM: Overview of the use of CoQ10 in cardiovascular disease. Biofactors. 9:273–284. 1999. View Article : Google Scholar : PubMed/NCBI | |
Digiesi V, Cantini F, Oradei A, Bisi G, Guarino GC, Brocchi A, Bellandi F, Mancini M and Littarru GP: Coenzyme Q10 in essential hypertension. Mol Aspects Med. 15 (Suppl 1):s257–s263. 1994. View Article : Google Scholar : PubMed/NCBI | |
Singh RB, Niaz MA, Rastogi SS, Shukla PK and Thakur AS: Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens. 13:203–208. 1999. View Article : Google Scholar : PubMed/NCBI | |
Pepe S, Marasco SF, Haas SJ, Sheeran FL, Krum H and Rosenfeldt FL: Coenzyme Q10 in cardiovascular disease. Mitochondrion. 7 (Suppl):S154–S167. 2007. View Article : Google Scholar : PubMed/NCBI | |
Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY and Watts GF: Coenzyme Q10 in the treatment of hypertension: A meta-analysis of the clinical trials. J Hum Hypertens. 21:297–306. 2007. View Article : Google Scholar : PubMed/NCBI | |
Serebruany VL, Ordonez JV, Herzog WR, Rohde M, Mortensen SA, Folkers K and Gurbel PA: Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression. J Cardiovasc Pharmacol. 29:16–22. 1997. View Article : Google Scholar : PubMed/NCBI | |
Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney JF Jr and Vita JA: Treatment of hypertension with ascorbic acid. Lancet. 354:2048–2049. 1999. View Article : Google Scholar : PubMed/NCBI | |
Afrose SA, Fahmeed A, Mujtaba A, Khan M and Noorulla SM: A study on effects of combining vitamin C with hypertension therapy. Int J Pharm Res Allied Sci. 4:142–146. 2015. | |
Juraschek SP, Guallar E, Appel LJ and Miller ER III: Effects of vitamin C supplementation on blood pressure: A meta-analysis of randomized controlled trials. Am J Clin Nutr. 95:1079–1088. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ried K, Travica N and Sali A: The acute effect of high-dose intravenous vitamin C and other nutrients on blood pressure: A cohort study. Blood Press Monit. 21:160–167. 2016. View Article : Google Scholar : PubMed/NCBI | |
Mahajan AS, Babbar R, Kansal N, Agarwal SK and Ray PC: Antihypertensive and antioxidant action of amlodipine and vitamin C in patients of essential hypertension. J Clin Biochem Nutr. 40:141–147. 2007. View Article : Google Scholar : PubMed/NCBI | |
Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J and Levine M: Vitamin C: Intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 5:e114142010. View Article : Google Scholar : PubMed/NCBI | |
Connor SL and Connor WE: Are fish oils beneficial in the prevention and treatment of coronary artery disease? Am J Clin Nutr. 66 (Suppl 4):1020S–1031S. 1997. View Article : Google Scholar : PubMed/NCBI | |
Simopoulos AP: Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr. 54:438–463. 1991. View Article : Google Scholar : PubMed/NCBI | |
Prisco D, Paniccia R, Bandinelli B, Filippini M, Francalanci I, Giusti B, Giurlani L, Gensini GF, Abbate R and Neri Serneri GG: Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res. 91:105–112. 1998. View Article : Google Scholar : PubMed/NCBI | |
Bønaa KH, Bjerve KS, Straume B, Gram IT and Thelle D: Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromsø study. N Engl J Med. 322:795–801. 1990. View Article : Google Scholar : PubMed/NCBI | |
Rasmussen BM, Vessby B, Uusitupa M, Berglund L, Pedersen E, Riccardi G, Rivellese AA, Tapsell L and Hermansen K; KANWU Study Group, : Effects of dietary saturated, monounsaturated, and n-3 fatty acids on blood pressure in healthy subjects. Am J Clin Nutr. 83:221–226. 2006. View Article : Google Scholar : PubMed/NCBI | |
Morris MC, Sacks F and Rosner B: Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation. 88:523–533. 1993. View Article : Google Scholar : PubMed/NCBI | |
Yagi S, Fukuda D, Aihara KI, Akaike M, Shimabukuro M and Sata M: n-3 Polyunsaturated fatty acids: Promising nutrients for preventing cardiovascular disease. J Atheroscler Thromb. 24:999–1010. 2017. View Article : Google Scholar : PubMed/NCBI | |
Innes JK and Calder PC: The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiometabolic risk factors: A systematic review. Int J Mol Sci. 19:E5322018. View Article : Google Scholar : PubMed/NCBI | |
Jovanovski E, Bateman EA, Bhardwaj J, Fairgrieve C, Mucalo I, Jenkins AL and Vuksan V: Effect of Rg3-enriched Korean red ginseng (Panax ginseng) on arterial stiffness and blood pressure in healthy individuals: A randomized controlled trial. J Am Soc Hypertens. 8:537–541. 2014. View Article : Google Scholar : PubMed/NCBI | |
Mucalo I, Jovanovski E, Rahelić D, Božikov V, Romić Z and Vuksan V: Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension. J Ethnopharmacol. 150:148–153. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kim JH: Cardiovascular diseases and Panax ginseng: A review on molecular mechanisms and medical applications. J Ginseng Res. 36:16–26. 2012. View Article : Google Scholar : PubMed/NCBI | |
Chen H, Yin J, Deng Y, Yang M, Xu L, Teng F, Li D, Cheng Y, Liu S, Wang D, et al: The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats. BMC Complement Altern Med. 12:532012. View Article : Google Scholar : PubMed/NCBI | |
Lee NH and Son CG: Systematic review of randomized controlled trials evaluating the efficacy and safety of ginseng. J Acupunct Meridian Stud. 4:85–97. 2011. View Article : Google Scholar : PubMed/NCBI | |
Stavro PM, Woo M, Heim TF, Leiter LA and Vuksan V: North American ginseng exerts a neutral effect on blood pressure in individuals with hypertension. Hypertension. 46:406–411. 2005. View Article : Google Scholar : PubMed/NCBI | |
Kim YS, Woo JY, Han CK and Chang IM: Safety analysis of Panax ginseng in randomized clinical trials: A systematic review. Medicines (Basel). 2:106–126. 2015. View Article : Google Scholar : PubMed/NCBI | |
Reinhart KM, Coleman CI, Teevan C, Vachhani P and White CM: Effects of garlic on blood pressure in patients with and without systolic hypertension: A meta-analysis. Ann Pharmacother. 42:1766–1771. 2008. View Article : Google Scholar : PubMed/NCBI | |
Ried K, Frank OR, Stocks NP, Fakler P and Sullivan T: Effect of garlic on blood pressure: A systematic review and meta-analysis. BMC Cardiovasc Disord. 8:132008. View Article : Google Scholar : PubMed/NCBI | |
Wang HP, Yang J, Qin LQ and Yang XJ: Effect of garlic on blood pressure: A meta-analysis. J Clin Hypertens (Greenwich). 17:223–231. 2015. View Article : Google Scholar : PubMed/NCBI | |
Ried K: Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: An updated meta-analysis and review. J Nutr. 146:389S–396S. 2016. View Article : Google Scholar : PubMed/NCBI | |
Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV and Orekhov AN: Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension. Hypertens Res. 32:433–437. 2009. View Article : Google Scholar : PubMed/NCBI | |
Nakasone Y, Nakamura Y, Yamamoto T and Yamaguchi H: Effect of a traditional Japanese garlic preparation on blood pressure in prehypertensive and mildly hypertensive adults. Exp Ther Med. 5:399–405. 2013. View Article : Google Scholar : PubMed/NCBI | |
United States Pharmacopeial Convention I. United States Pharmacopoeia 38 Garlic Fluid Extract USP 28-NF 33. United States Pharmacopeial Convention; Rockville, MD: pp. 6052–6055. 2015 | |
Ried K, Frank OR and Stocks NP: Aged garlic extract reduces blood pressure in hypertensives: A dose-response trial. Eur J Clin Nutr. 67:64–70. 2013. View Article : Google Scholar : PubMed/NCBI | |
Ried K, Travica N and Sali A: The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: The AGE at heart trial. Integr Blood Press Control. 9:9–21. 2016. View Article : Google Scholar : PubMed/NCBI | |
Ried K, Travica N and Sali A: The effect of Kyolic aged garlic extract on gut microbiota, inflammation, and cardiovascular markers in hypertensives: The GarGIC trial. Front Nutr. 5:1222018. View Article : Google Scholar : PubMed/NCBI | |
Ushijima M, Takashima M, Kunimura K, Kodera Y, Morihara N and Tamura K: Effects of S-1-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats. J Pharm Pharmacol. 70:559–565. 2018. View Article : Google Scholar : PubMed/NCBI | |
Morihara N, Sumioka I, Moriguchi T, Uda N and Kyo E: Aged garlic extract enhances production of nitric oxide. Life Sci. 71:509–517. 2002. View Article : Google Scholar : PubMed/NCBI | |
Takashima M, Kanamori Y, Kodera Y, Morihara N and Tamura K: Aged garlic extract exerts endothelium-dependent vasorelaxant effect on rat aorta by increasing nitric oxide production. Phytomedicine. 24:56–61. 2017. View Article : Google Scholar : PubMed/NCBI | |
Benavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE and Kraus DW: Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci USA. 104:17977–17982. 2007. View Article : Google Scholar : PubMed/NCBI | |
Mohamadi A, Jarrell ST, Shi SJ, Andrawis NS, Myers A, Clouatre D and Preuss HG: Effects of wild versus cultivated garlic on blood pressure and other parameters in hypertensive rats. Heart Dis. 2:3–9. 2000.PubMed/NCBI | |
Cruz C, Correa-Rotter R, Sánchez-González DJ, Hernández-Pando R, Maldonado PD, Martínez-Martínez CM, Medina-Campos ON, Tapia E, Aguilar D, Chirino YI, et al: Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats. Am J Physiol Renal Physiol. 293:F1691–F1698. 2007. View Article : Google Scholar : PubMed/NCBI | |
Matsutomo T, Ushijima M, Kunimura K and Ohtani M: Metabolomic study reveals the acute hypotensive effect of S-1-propenylcysteine accompanied by alteration of the plasma histidine level in spontaneously hypertensive rats. J Pharm Biomed Anal. 168:148–154. 2019. View Article : Google Scholar : PubMed/NCBI | |
Matsutomo T, Ushijima M, Kodera Y, Nakamoto M, Takashima M, Morihara N and Tamura K: Metabolomic study on the antihypertensive effect of S-1-propenylcysteine in spontaneously hypertensive rats using liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 1046:147–155. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ackermann RT, Mulrow CD, Ramirez G, Gardner CD, Morbidoni L and Lawrence VA: Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med. 161:813–824. 2001. View Article : Google Scholar : PubMed/NCBI | |
Borrelli F, Capasso R and Izzo AA: Garlic (Allium sativum L.): Adverse effects and drug interactions in humans. Mol Nutr Food Res. 51:1386–1397. 2007. View Article : Google Scholar : PubMed/NCBI | |
Varshney R and Budoff MJ: Garlic and Heart Disease. J Nutr. 146:416S–421S. 2016. View Article : Google Scholar : PubMed/NCBI | |
Qi Y, Kim S, Richards EM, Raizada MK and Pepine CJ: Gut microbiota: Potential for a unifying hypothesis for prevention and treatment of hypertension. Circ Res. 120:1724–1726. 2017. View Article : Google Scholar : PubMed/NCBI | |
Yang T, Santisteban MM, Rodriguez V, Li E, Ahmari N, Carvajal JM, Zadeh M, Gong M, Qi Y, Zubcevic J, et al: Gut dysbiosis is linked to hypertension. Hypertension. 65:1331–1340. 2015. View Article : Google Scholar : PubMed/NCBI | |
Li J, Zhao F, Wang Y, Chen J, Tao J, Tian G, Wu S, Liu W, Cui Q, Geng B, et al: Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome. 5:142017. View Article : Google Scholar : PubMed/NCBI | |
Naruszewicz M, Johansson ML, Zapolska-Downar D and Bukowska H: Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers. Microbiome. 5:142017.PubMed/NCBI | |
Mizushima S, Ohshige K, Watanabe J, Kimura M, Kadowaki T, Nakamura Y, Tochikubo O and Ueshima H: Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men. Am J Hypertens. 17:701–706. 2004. View Article : Google Scholar : PubMed/NCBI | |
Inoue K, Shirai T, Ochiai H, Kasao M, Hayakawa K, Kimura M and Sansawa H: Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr. 57:490–495. 2003. View Article : Google Scholar : PubMed/NCBI | |
Aoyagi Y, Park S, Matsubara S, Honda Y, Amamoto R, Kushiro A, Miyazaki K and Shephard RJ: Habitual intake of fermented milk products containing Lactobacillus casei strain Shirota and a reduced risk of hypertension in older people. Benef Microbes. 8:23–29. 2017. View Article : Google Scholar : PubMed/NCBI | |
Agerholm-Larsen L, Raben A, Haulrik N, Hansen AS, Manders M and Astrup A: Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Eur J Clin Nutr. 54:288–297. 2000. View Article : Google Scholar : PubMed/NCBI | |
Tabuchi M, Ozaki M, Tamura A, Yamada N, Ishida T, Hosoda M and Hosono A: Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem. 67:1421–1424. 2003. View Article : Google Scholar : PubMed/NCBI | |
Seppo L, Jauhiainen T, Poussa T and Korpela R: A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr. 77:326–330. 2003. View Article : Google Scholar : PubMed/NCBI | |
Khalesi S, Sun J, Buys N and Jayasinghe R: Effect of probiotics on blood pressure: A systematic review and meta-analysis of randomized, controlled trials. Hypertension. 64:897–903. 2014. View Article : Google Scholar : PubMed/NCBI | |
Tanida M, Yamano T, Maeda K, Okumura N, Fukushima Y and Nagai K: Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats. Neurosci Lett. 389:109–114. 2005. View Article : Google Scholar : PubMed/NCBI |