Open Access

T lymphocytes in IgA nephropathy (Review)

  • Authors:
    • Yuyan Tang
    • Haidong He
    • Pin Hu
    • Xudong Xu
  • View Affiliations

  • Published online on: April 22, 2020     https://doi.org/10.3892/etm.2020.8673
  • Pages: 186-194
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Immunoglobulin A nephropathy (IgAN), the most common primary glomerulonephritis worldwide, is the main cause of end‑stage renal disease. IgAN is characterized by the accumulation of immune complexes in the circulation, which contain abnormal levels of IgA. IgAN primarily results from galactose‑deficient IgA1 (Gd‑IgA1) and Gd‑IgA1 deposition in the renal mesangium, causing local proliferation and matrix expansion. Gd‑IgA1 has been confirmed as one of the key effectors in the pathogenesis of IgAN, but the origin of Gd‑IgA1 is not clear. Recent studies have shown that Gd‑IgA1 deposition could be the result of mucosally primed plasma cells and is associated with T cell dysregulation. T cells contribute to the IgA response and play an important role in the development of IgAN. In the present review, the latest discoveries regarding the role of T lymphocytes in the pathogenesis of IgAN have been summarized. Understanding these advances will allow novel therapeutic strategies for the treatment of IgAN.
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July-2020
Volume 20 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tang Y, He H, Hu P and Xu X: T lymphocytes in IgA nephropathy (Review). Exp Ther Med 20: 186-194, 2020.
APA
Tang, Y., He, H., Hu, P., & Xu, X. (2020). T lymphocytes in IgA nephropathy (Review). Experimental and Therapeutic Medicine, 20, 186-194. https://doi.org/10.3892/etm.2020.8673
MLA
Tang, Y., He, H., Hu, P., Xu, X."T lymphocytes in IgA nephropathy (Review)". Experimental and Therapeutic Medicine 20.1 (2020): 186-194.
Chicago
Tang, Y., He, H., Hu, P., Xu, X."T lymphocytes in IgA nephropathy (Review)". Experimental and Therapeutic Medicine 20, no. 1 (2020): 186-194. https://doi.org/10.3892/etm.2020.8673