MicroRNA‑513a‑3p regulates colorectal cancer cell metabolism via targeting hexokinase 2

  • Authors:
    • Chen Li
    • Zhijin Yu
    • Jinpeng Ye
  • View Affiliations

  • Published online on: May 7, 2020     https://doi.org/10.3892/etm.2020.8727
  • Pages: 572-580
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Abstract

Disruption of cell metabolism is a hallmark of cancer cells. Accumulating evidence suggests that microRNAs (miRNAs/miRs) are involved in almost all physiological and pathological processes. The aberrant expression of miRNAs induces metabolic reprogramming in cancer cells and thus, promotes proliferation. In the current study, miR‑513a‑3p was identified as a significantly downregulated miRNA in colorectal cancer cells and tumors. Overexpression of miR‑513a‑3p in colorectal cancer cells inhibited proliferation and glycolysis. A well‑documented metabolic regulator, hexokinase 2 (HK2), was predicted and validated HK2to be a target gene of miR‑513a‑3p in colorectal cancer cells. In addition, overexpression of HK2 reversed the miR‑513a‑3p mimic‑induced inhibition of proliferation. The association between HK2 and miR‑513a‑3p was further observed in tumors collected from patients with colorectal cancer. The findings suggest that miR‑513a‑5p may inhibit glycolysis in colorectal cancer cells via repressing HK2 expression, indicating that miR‑513a‑5p may be a tumor suppressor in colorectal cancer.
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July-2020
Volume 20 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li C, Yu Z and Ye J: MicroRNA‑513a‑3p regulates colorectal cancer cell metabolism via targeting hexokinase 2. Exp Ther Med 20: 572-580, 2020
APA
Li, C., Yu, Z., & Ye, J. (2020). MicroRNA‑513a‑3p regulates colorectal cancer cell metabolism via targeting hexokinase 2. Experimental and Therapeutic Medicine, 20, 572-580. https://doi.org/10.3892/etm.2020.8727
MLA
Li, C., Yu, Z., Ye, J."MicroRNA‑513a‑3p regulates colorectal cancer cell metabolism via targeting hexokinase 2". Experimental and Therapeutic Medicine 20.1 (2020): 572-580.
Chicago
Li, C., Yu, Z., Ye, J."MicroRNA‑513a‑3p regulates colorectal cancer cell metabolism via targeting hexokinase 2". Experimental and Therapeutic Medicine 20, no. 1 (2020): 572-580. https://doi.org/10.3892/etm.2020.8727