Open Access

Role of the lysyl oxidase family in organ development (Review)

  • Authors:
    • Shanzun Wei
    • Liang Gao
    • Changjing Wu
    • Feng Qin
    • Jiuhong Yuan
  • View Affiliations

  • Published online on: May 8, 2020     https://doi.org/10.3892/etm.2020.8731
  • Pages: 163-172
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lysyl oxidase proteins (LOXs) are amine oxidases, which are mainly located in smooth muscle cells and fibroblasts and serve an important role in the formation of the extracellular matrix (ECM) in a copper‑dependent manner. Owing to the ability of LOX proteins to modulate crosslinking between collagens and to promote the deposition of other fibers, they serve crucially in organogenesis and the subsequent organ development, as well as disease initiation and progression. In addition, ECM formation significantly influences organ morphological formation in both cancer‑ and non‑tumor‑related diseases, in addition to cellular epigenetic transformation and migration, under the influence of LOXs. A number of different signaling pathways regulate the LOXs expression and their enzymatic activation. The tissue remodeling and transformation process shares some resemblance between oncogenesis and embryogenesis. Additionally the roles that LOXs serve appeared to be stressed during oncogenesis and tumor metastasis. It has also been indicated LOXs have a noteworthy role in non‑tumor diseases. Nonetheless, the role of LOXs in systemic or local organ development and disease control remains unknown. In the present study, the essential roles that LOXs play in embryogenesis were unveiled partially, whereas the role of LOXs in organ or systematic development requires further investigations. The present review aimed to discuss the roles of members of the LOX family in the context of the remodeling of organogenesis and organ development. In addition, the consequences of the malfunction of these proteins related to the development of abnormalities and resulting diseases is discussed.
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July-2020
Volume 20 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wei S, Gao L, Wu C, Qin F and Yuan J: Role of the lysyl oxidase family in organ development (Review) . Exp Ther Med 20: 163-172, 2020
APA
Wei, S., Gao, L., Wu, C., Qin, F., & Yuan, J. (2020). Role of the lysyl oxidase family in organ development (Review) . Experimental and Therapeutic Medicine, 20, 163-172. https://doi.org/10.3892/etm.2020.8731
MLA
Wei, S., Gao, L., Wu, C., Qin, F., Yuan, J."Role of the lysyl oxidase family in organ development (Review) ". Experimental and Therapeutic Medicine 20.1 (2020): 163-172.
Chicago
Wei, S., Gao, L., Wu, C., Qin, F., Yuan, J."Role of the lysyl oxidase family in organ development (Review) ". Experimental and Therapeutic Medicine 20, no. 1 (2020): 163-172. https://doi.org/10.3892/etm.2020.8731