Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series

Șuță,Marius   Cristian; Karancsi,Olimpiu   Ladislau; Mușat,Ovidiu; Balica,Nicolae; Yasar,Iasmina; Roșca,Cosmin; Stanca,Simona; Dărăbuş,Diana‑Maria

doi:10.3892/etm.2020.8883

Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series

Authors:
- Marius Cristian Șuță
- Olimpiu Ladislau Karancsi
- Ovidiu Mușat
- Nicolae Balica
- Iasmina Yasar
- Cosmin Roșca
- Simona Stanca
- Diana‑Maria Dărăbuş
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Affiliations: Department of Ophthalmology, ‘Victor Babeş’ University of Medicine and Pharmacy, 300041 Timișoara, Romania, Department of Oral Implantology and Prosthetic Restorations on Implants, ‘Victor Babeş’ University of Medicine and Pharmacy, 300041 Timișoara, Romania, Department of Ophthalmology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010825 Bucharest, Romania, Department of ENT, ‘Victor Babeş’ University of Medicine and Pharmacy, Timişoara County Emergency Clinical Hospital, 300041 Timişoara, Romania, Department of Ophthalmology, Timişoara County Emergency Clinical Hospital, 300041 Timişoara, Romania, Department of Ophthalmology, Oculens Clinic, 400501 Cluj‑Napoca, Romania, Department of Pediatrics, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
Published online on: June 12, 2020 https://doi.org/10.3892/etm.2020.8883
Pages: 2524-2528
Copyright: © Șuță et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Due to their anti‑inflammatory, antiangiogenic and antiedematous properties, corticosteroids have been commonly used in the treatment of retinal diseases. Intravitreal administration of steroids offers the maximal drug efficacy and the lowest risk of systemic side effects. The authors report three cases of presumed sterile endophthalmitis induced by triamcinolone acetonide (TA) in three eyes with intermediate non‑infectious uveitis. Each patient received a single intravitreal injection of TA of 4 mg. Because of the intense vitreous inflammatory reaction, retina examination and the optical coherence tomography could not be performed, although vitreous opacities were observed on the ocular ultrasound. The dense vitreous opacity is a defining factor, the anterior segment inflammation is mild to moderate and a hypopyon is present, which may be a sterile inflammatory reaction or the triamcinolone material itself. In cases of sterile endophthalmitis, the visual acuity increases progressively as the intraocular inflammation diminishes. Local treatment with topical antibiotics, prednisolone acetate and cycloplegic eyedrops is recommended to control the inflammatory reaction.

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