Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin E

Aierken,Aibibai; Yusufu,Bweimaieryemu; Xu,Peiru

doi:10.3892/etm.2020.8949

Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin E

Authors:
- Aibibai Aierken
- Bweimaieryemu Yusufu
- Peiru Xu
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Affiliations: Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Department of Pediatrics, First people's Hospital of Kashi, Kashi, Xinjiang 844000, P.R. China
Published online on: June 26, 2020 https://doi.org/10.3892/etm.2020.8949
Pages: 2122-2126
Copyright: © Aierken et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin was investigated. A total of 60 child patients with asthma who met the inclusion criteria and received treatment from January 2016 to October 2017 were collected. Among them, 17 asthmatic infants with rickets were set as observation group, while 43 child patients with simple asthma were regarded as the control group. Venous blood was drawn from the two groups of subjects after admission. The levels of interleukin‑1 (IL‑1), IL‑6 and IL‑17 in serum were determined by ELISA, vitamin D and immunoglobulin E levels in serum were detected using a fully‑automatic biochemical analyzer, and wheezing duration during asthma attack was recorded. IL‑1, IL‑6, IL‑17 and immunoglobulin E levels in serum of observation group were significantly higher than those of the control group (P<0.05). The vitamin D level in the observation group was remarkably lower than that in the control group (P<0.05). Wheezing duration in observation group was evidently longer than that in control group (P<0.05). Moreover, IL‑1, IL‑6, IL‑17 and immunoglobulin E levels in serum were positively related to wheezing duration, but the vitamin D level was negatively associated with wheezing duration. Infantile asthma with rickets is closely correlated with vitamin D, inflammatory factors and immunoglobulin E, which are major risk factors in infantile asthma with rickets.

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