Open Access

Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review)

  • Authors:
    • Can Xia
    • Yu Tao
    • Mingshan Li
    • Tuanjie Che
    • Jing Qu
  • View Affiliations

  • Published online on: July 29, 2020     https://doi.org/10.3892/etm.2020.9073
  • Pages: 2923-2940
  • Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cells primarily rely on proteins to perform the majority of their physiological functions, and the function of proteins is regulated by post‑translational modifications (PTMs). The acetylation of proteins is a dynamic and highly specific PTM, which has an important influence on the functions of proteins, such as gene transcription and signal transduction. The acetylation of proteins is primarily dependent on lysine acetyltransferases and lysine deacetylases. In recent years, due to the widespread use of mass spectrometry and the emergence of new technologies, such as protein chips, studies on protein acetylation have been further developed. Compared with histone acetylation, acetylation of non‑histone proteins has gradually become the focus of research due to its important regulatory mechanisms and wide range of applications. The discovery of specific protein acetylation sites using bioinformatic tools can greatly aid the understanding of the underlying mechanisms of protein acetylation involved in related physiological and pathological processes.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Xia C, Tao Y, Li M, Che T and Qu J: Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review). Exp Ther Med 20: 2923-2940, 2020.
APA
Xia, C., Tao, Y., Li, M., Che, T., & Qu, J. (2020). Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review). Experimental and Therapeutic Medicine, 20, 2923-2940. https://doi.org/10.3892/etm.2020.9073
MLA
Xia, C., Tao, Y., Li, M., Che, T., Qu, J."Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review)". Experimental and Therapeutic Medicine 20.4 (2020): 2923-2940.
Chicago
Xia, C., Tao, Y., Li, M., Che, T., Qu, J."Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review)". Experimental and Therapeutic Medicine 20, no. 4 (2020): 2923-2940. https://doi.org/10.3892/etm.2020.9073