Open Access

Panax notoginseng saponins alleviates advanced glycation end product‑induced apoptosis by upregulating SIRT1 and antioxidant expression levels in HUVECs

  • Authors:
    • Yang Bo
    • Zhang Jian
    • Sun Zhi‑Jun
    • Wu Quing
    • Zhao Hua
    • Li Chuan‑Wei
    • Cao Yu‑Kang
  • View Affiliations

  • Published online on: September 17, 2020     https://doi.org/10.3892/etm.2020.9229
  • Article Number: 99
  • Copyright: © Bo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study examined whether Panax notoginseng saponins (PNS) alleviated advanced glycation end product (AGE)‑induced apoptosis in human umbilical vein endothelial cells (HUVECs). HUVECs were incubated with 300 µg/ml AGEs alone or AGEs and PNS (0.05, 0.5 or 1 mg/ml) for 48 h. The results of the present study demonstrated that PNS effectively promoted cell viability, inhibited apoptosis and suppressed the activity of caspase‑3 in AGE‑induced HUVECs. The activities of monocyte chemoattractant protein‑1 and malondialdehyde were reduced, and superoxide dismutase activity was increased following treatment with PNS. Furthermore, PNS significantly increased the expression of silent information regulator 1 (SIRT1) and transforming growth factor (TGF)‑β1 proteins, and suppressed the expression of inducible nitric oxide synthase and cyclooxyggenase‑2 proteins in AGE‑induced HUVECs. Therefore, the present study demonstrated that PNS reduced AGE‑induced apoptosis by upregulating SIRT1 and antioxidants in HUVECs. The present findings suggest that the PNS may as an important pharmacological agent for AGE‑induced cardiovascular injury.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Bo Y, Jian Z, Zhi‑Jun S, Quing W, Hua Z, Chuan‑Wei L and Yu‑Kang C: <em>Panax notoginseng</em> saponins alleviates advanced glycation end product‑induced apoptosis by upregulating SIRT1 and antioxidant expression levels in HUVECs. Exp Ther Med 20: 99, 2020
APA
Bo, Y., Jian, Z., Zhi‑Jun, S., Quing, W., Hua, Z., Chuan‑Wei, L., & Yu‑Kang, C. (2020). <em>Panax notoginseng</em> saponins alleviates advanced glycation end product‑induced apoptosis by upregulating SIRT1 and antioxidant expression levels in HUVECs. Experimental and Therapeutic Medicine, 20, 99. https://doi.org/10.3892/etm.2020.9229
MLA
Bo, Y., Jian, Z., Zhi‑Jun, S., Quing, W., Hua, Z., Chuan‑Wei, L., Yu‑Kang, C."<em>Panax notoginseng</em> saponins alleviates advanced glycation end product‑induced apoptosis by upregulating SIRT1 and antioxidant expression levels in HUVECs". Experimental and Therapeutic Medicine 20.5 (2020): 99.
Chicago
Bo, Y., Jian, Z., Zhi‑Jun, S., Quing, W., Hua, Z., Chuan‑Wei, L., Yu‑Kang, C."<em>Panax notoginseng</em> saponins alleviates advanced glycation end product‑induced apoptosis by upregulating SIRT1 and antioxidant expression levels in HUVECs". Experimental and Therapeutic Medicine 20, no. 5 (2020): 99. https://doi.org/10.3892/etm.2020.9229