Single‑nucleotide polymorphisms and haplotypes in the interleukin‑33 gene are associated with a risk of allergic rhinitis in the Chinese population
- Authors:
- He Ran
- Hua Xiao
- Xing Zhou
- Lijun Guo
- Shuang Lu
-
Affiliations: Department of Otolaryngology Head and Neck Surgery, The Second Hospital of Jingzhou, Jingzhou, Hubei 434000, P.R. China, Hubei College of Chinese Medicine, Jingzhou, Hubei 434020, P.R. China, Department of Otolaryngology Head and Neck Surgery, Shishou People's Hospital, Jingzhou, Hubei 434400, P.R. China - Published online on: September 17, 2020 https://doi.org/10.3892/etm.2020.9232
- Article Number: 102
This article is mentioned in:
Abstract
Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, et al: Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the world health organization, GA(2)LEN and AllerGen). Allergy. 63 (Suppl 86):S8–S160. 2008.PubMed/NCBI View Article : Google Scholar | |
Leynaert B, Neukirch F, Demoly P and Bousquet J: Epidemiologic evidence for asthma and rhinitis comorbidity. J Allergy Clin Immunol. 106 (5 Suppl):S201–S205. 2000.PubMed/NCBI View Article : Google Scholar | |
Bousquet J, Van Cauwenberge P and Khaltaev N: Aria Workshop Group; World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 108 (5 Suppl):S147–S334. 2001.PubMed/NCBI View Article : Google Scholar | |
Falade AG, Ige OM, Yusuf BO, Onadeko MO and Onadeko BO: Trends in the prevalence and severity of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema. J Natl Med Assoc. 101:414–418. 2009.PubMed/NCBI View Article : Google Scholar | |
Nathan RA: The burden of allergic rhinitis. Allergy Asthma Proc. 28:3–9. 2007.PubMed/NCBI View Article : Google Scholar | |
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, atopic eczema. ISAAC. The international study of asthma and allergies in childhood (ISAAC) steering committee. Lancet. 351:1225–1232. 1998.PubMed/NCBI View Article : Google Scholar | |
Haahtela T, Holgate S, Pawankar R, Akdis CA, Benjaponpitak S, Caraballo L, Demain J, Portnoy J and von Hertzen L: WAO Special Committee on Climate Change and Biodiversity. The biodiversity hypothesis and allergic disease: World allergy organization position statement. World Allergy Organ J. 6(3)2013.PubMed/NCBI View Article : Google Scholar | |
Wang XD, Zheng M, Lou HF, Wang CS, Zhang Y, Bo MY, Ge SQ, Zhang N, Zhang L and Bachert C: An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011. Allergy. 71:1170–1180. 2016.PubMed/NCBI View Article : Google Scholar | |
Thompson AK, Juniper E and Meltzer EO: Quality of life in patients with allergic rhinitis. Ann Allergy Asthma Immunol. 85:338–347; quiz 347-8. 2000.PubMed/NCBI View Article : Google Scholar | |
Dunlop J, Matsui E and Sharma HP: Allergic rhinitis: Environmental determinants. Immunol Allergy Clin North Am. 36:367–377. 2016.PubMed/NCBI View Article : Google Scholar | |
Greiner AN, Hellings PW, Rotiroti G and Scadding GK: Allergic rhinitis. Lancet. 378:2112–2122. 2011.PubMed/NCBI View Article : Google Scholar | |
Portelli MA, Hodge E and Sayers I: Genetic risk factors for the development of allergic disease identified by genome-wide association. Clin Exp Allergy. 45:21–31. 2015.PubMed/NCBI View Article : Google Scholar | |
Willemsen G, van Beijsterveldt TC, van Baal CG, Postma D and Boomsma DI: Heritability of self-reported asthma and allergy: A study in adult Dutch twins, siblings and parents. Twin Res Hum Genet. 11:132–142. 2008.PubMed/NCBI View Article : Google Scholar | |
Fagnani C, Annesi-Maesano I, Brescianini S, D'Ippolito C, Medda E, Nisticò L, Patriarca V, Rotondi D, Toccaceli V and Stazi MA: Heritability and shared genetic effects of asthma and hay fever: An Italian study of young twins. Twin Res Hum Genet. 11:121–131. 2008.PubMed/NCBI View Article : Google Scholar | |
Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP, Cohain A, Linderman M, Torgerson DG, et al: Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. BMC Med Genomics. 7(48)2014.PubMed/NCBI View Article : Google Scholar | |
Andiappan AK, Wang de Y, Anantharaman R, Parate PN, Suri BK, Low HQ, Li Y, Zhao W, Castagnoli P, Liu J and Chew FT: Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population. PLoS One. 6(e19719)2011.PubMed/NCBI View Article : Google Scholar | |
Fujii R, Hishida A, Wu MC, Kondo T, Hattori Y, Naito M, Endoh K, Nakatochi M, Hamajima N, Kubo M, et al: Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population. Nagoya J Med Sci. 80:109–120. 2018.PubMed/NCBI View Article : Google Scholar | |
Shen Y, Liu Y, Wang XQ, Ke X, Kang HY and Hong SL: Association between TNFSF4 and BLK gene polymorphisms and susceptibility to allergic rhinitis. Mol Med Rep. 16:3224–3232. 2017.PubMed/NCBI View Article : Google Scholar | |
Zhang Y, Lin X, Desrosiers M, Zhang W, Meng N, Zhao L, Han D and Zhang L: Association pattern of interleukin-1 receptor-associated kinase-4 gene polymorphisms with allergic rhinitis in a Han Chinese population. PLoS One. 6(e21769)2011.PubMed/NCBI View Article : Google Scholar | |
Ke X, Song S, Wang X, Shen Y, Kang H and Hong S: Associations of single nucleotide polymorphisms of PTPN22 and Ctla4 genes with the risk of allergic rhinitis in a Chinese Han population. Hum Immunol. 78:227–231. 2017.PubMed/NCBI View Article : Google Scholar | |
Kanazawa J, Masuko H, Yatagai Y, Sakamoto T, Yamada H, Kitazawa H, Iijima H, Naito T, Saito T, Noguchi E, et al: Association analyses of eQTLs of the TYRO3 gene and allergic diseases in Japanese populations. Allergol Int. 68:77–81. 2019.PubMed/NCBI View Article : Google Scholar | |
Ke X, Yang Y, Shen Y, Wang X and Hong S: Association between TNFAIP3 gene polymorphisms and risk of allergic rhinitis in a Chinese Han population. Iran J Allergy Asthma Immunol. 15:46–52. 2016.PubMed/NCBI | |
Nilsson D, Andiappan AK, Hallden C, Tim CF, Säll T, Wang de Y and Cardell LO: Poor reproducibility of allergic rhinitis SNP associations. PLoS One. 8(e53975)2013.PubMed/NCBI View Article : Google Scholar | |
Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C and Schoettler N: 23andMe Research Team; AAGC collaborators, Flores C, et al. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 50:1072–1080. 2018.PubMed/NCBI View Article : Google Scholar | |
Li J, Zhang Y and Zhang L: Discovering susceptibility genes for allergic rhinitis and allergy using a genome-wide association study strategy. Curr Opin Allergy Clin Immunol. 15:33–40. 2015.PubMed/NCBI View Article : Google Scholar | |
Romagnani S: The increased prevalence of allergy and the hygiene hypothesis: Missing immune deviation, reduced immune suppression, or both? Immunology. 112:352–363. 2004.PubMed/NCBI View Article : Google Scholar | |
Romagnani S: Lymphokine production by human T cells in disease states. Annu Rev Immunol. 12:227–257. 1994.PubMed/NCBI View Article : Google Scholar | |
Abbas AK, Murphy KM and Sher A: Functional diversity of helper T lymphocytes. Nature. 383:787–793. 1996.PubMed/NCBI View Article : Google Scholar | |
Li L, Xia Y, Nguyen A, Lai YH, Feng L, Mosmann TR and Lo D: Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J Immunol. 162:2477–2487. 1999.PubMed/NCBI | |
Durham SR, Ying S, Varney VA, Jacobson MR, Sudderick RM, Mackay IS, Kay AB and Hamid QA: Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: Relationship to tissue eosinophilia. J Immunol. 148:2390–2394. 1992.PubMed/NCBI | |
Bischoff SC, Sellge G, Lorentz A, Sebald W, Raab R and Manns MP: IL-4 enhances proliferation and mediator release in mature human mast cells. Proc Natl Acad Sci USA. 96:8080–8085. 1999.PubMed/NCBI View Article : Google Scholar | |
Hardman CS, Panova V and McKenzie AN: IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation. Eur J Immunol. 43:488–498. 2013.PubMed/NCBI View Article : Google Scholar | |
Bystrom J, Patel SY, Amin K and Bishop-Bailey D: Dissecting the role of eosinophil cationic protein in upper airway disease. Curr Opin Allergy Clin Immunol. 12:18–23. 2012.PubMed/NCBI View Article : Google Scholar | |
Prefontaine D, Nadigel J, Chouiali F, Audusseau S, Semlali A, Chakir J, Martin JG and Hamid Q: Increased IL-33 expression by epithelial cells in bronchial asthma. J Allergy Clin Immunol. 125:752–754. 2010.PubMed/NCBI View Article : Google Scholar | |
Lloyd CM: IL-33 family members and asthma-bridging innate and adaptive immune responses. Curr Opin Immunol. 22:800–806. 2010.PubMed/NCBI View Article : Google Scholar | |
Shimizu M, Matsuda A, Yanagisawa K, Hirota T, Akahoshi M, Inomata N, Ebe K, Tanaka K, Sugiura H, Nakashima K, et al: Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis. Hum Mol Genet. 14:2919–2927. 2005.PubMed/NCBI View Article : Google Scholar | |
Grotenboer NS, Ketelaar ME, Koppelman GH and Nawijn MC: Decoding asthma: Translating genetic variation in IL-33 and IL1RL1 into disease pathophysiology. J Allergy Clin Immunol. 131:856–865. 2013.PubMed/NCBI View Article : Google Scholar | |
Watanabe M, Nakamoto K, Inui T, Sada M, Honda K, Tamura M, Ogawa Y, Yokoyama T, Saraya T, Kurai D, et al: Serum sST2 levels predict severe exacerbation of asthma. Respir Res. 19(169)2018.PubMed/NCBI View Article : Google Scholar | |
Li R, Yang G, Yang R, Peng X and Li J: Interleukin-33 and receptor ST2 as indicators in patients with asthma: A meta-analysis. Int J Clin Exp Med. 8:14935–14943. 2015.PubMed/NCBI | |
Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, et al: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 23:479–490. 2005.PubMed/NCBI View Article : Google Scholar | |
Oshikawa K, Yanagisawa K, Tominaga S and Sugiyama Y: Expression and function of the ST2 gene in a murine model of allergic airway inflammation. Clin Exp Allergy. 32:1520–1526. 2002.PubMed/NCBI View Article : Google Scholar | |
Lohning M, Stroehmann A, Coyle AJ, Grogan JL, Lin S, Gutierrez-Ramos JC, Levinson D, Radbruch A and Kamradt T: T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci USA. 95:6930–6935. 1998.PubMed/NCBI View Article : Google Scholar | |
Coyle AJ, Lloyd C, Tian J, Nguyen T, Erikkson C, Wang L, Ottoson P, Persson P, Delaney T, Lehar S, et al: Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med. 190:895–902. 1999.PubMed/NCBI View Article : Google Scholar | |
Xu D, Chan WL, Leung BP, Huang FP, Wheeler R, Piedrafita D, Robinson JH and Liew FY: Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J Exp Med. 187:787–794. 1998.PubMed/NCBI View Article : Google Scholar | |
Lecart S, Lecointe N, Subramaniam A, Alkan S, Ni D, Chen R, Boulay V, Pène J, Kuroiwa K, Tominaga S and Yssel H: Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface. Eur J Immunol. 32:2979–2987. 2002.PubMed/NCBI View Article : Google Scholar | |
Trajkovic V, Sweet MJ and Xu D: T1/ST2-an IL-1 receptor-like modulator of immune responses. Cytokine Growth Factor Rev. 15:87–95. 2004.PubMed/NCBI View Article : Google Scholar | |
Ding W, Zou GL, Zhang W, Lai XN, Chen HW and Xiong LX: Interleukin-33: Its emerging role in allergic diseases. Molecules. 23(1665)2018.PubMed/NCBI View Article : Google Scholar | |
Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Imoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, et al: A critical role of IL-33 in experimental allergic rhinitis. J Allergy Clin Immunol. 130:184–194 e11. 2012.PubMed/NCBI View Article : Google Scholar | |
Gluck J, Rymarczyk B and Rogala B: Serum IL-33 but not ST2 level is elevated in intermittent allergic rhinitis and is a marker of the disease severity. Inflamm Res. 61:547–550. 2012.PubMed/NCBI View Article : Google Scholar | |
Sakashita M, Yoshimoto T, Hirota T, Harada M, Okubo K, Osawa Y, Fujieda S, Nakamura Y, Yasuda K, Nakanishi K and Tamari M: Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis. Clin Exp Allergy. 38:1875–1881. 2008.PubMed/NCBI View Article : Google Scholar | |
Du Y, Luo Y, Yang C, Liu J, Wan J and Wang K: Discussion IL-33 and its receptor ST2 associated with the pathogenesis of allergic rhinitis. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 29:811–814. 2015.PubMed/NCBI(In Chinese). | |
Guo-Zhu H, Xi-Ling Z, Zhu W, Li-Hua W, Dan H, Xiao-Mu W, Wen-Yun Z and Wei-Xu H: Therapeutic potential of combined anti-IL-1β IgY and anti-TNF-α IgY in guinea pigs with allergic rhinitis induced by ovalbumin. Int Immunopharmacol. 25:155–161. 2015.PubMed/NCBI View Article : Google Scholar | |
Asaka D, Yoshikawa M, Nakayama T, Yoshimura T, Moriyama H and Otori N: Elevated levels of interleukin-33 in the nasal secretions of patients with allergic rhinitis. Int Arch Allergy Immunol. 158 (Suppl 1):S47–S50. 2012.PubMed/NCBI View Article : Google Scholar | |
Kim YH, Yang TY, Park CS, Ahn SH, Son BK, Kim JH, Lim DH and Jang TY: Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis. Allergy. 67:183–190. 2012.PubMed/NCBI View Article : Google Scholar | |
Kamekura R, Kojima T, Takano K, Go M, Sawada N and Himi T: The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis. Clin Exp Allergy. 42:218–228. 2012.PubMed/NCBI View Article : Google Scholar | |
Shaw JL, Fakhri S, Citardi MJ, Porter PC, Corry DB, Kheradmand F, Liu YJ and Luong A: IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med. 188:432–439. 2013.PubMed/NCBI View Article : Google Scholar | |
Soyka MB, Holzmann D, Basinski TM, Wawrzyniak M, Bannert C, Bürgler S, Akkoc T, Treis A, Rückert B, Akdis M, et al: The induction of IL-33 in the sinus epithelium and its influence on T-helper cell responses. PLoS One. 10(e0123163)2015.PubMed/NCBI View Article : Google Scholar | |
Baumann R, Rabaszowski M, Stenin I, Tilgner L, Gaertner-Akerboom M, Scheckenbach K, Wiltfang J, Chaker A, Schipper J and Wagenmann M: Nasal levels of soluble IL-33R ST2 and IL-16 in allergic rhinitis: Inverse correlation trends with disease severity. Clin Exp Allergy. 43:1134–1143. 2013.PubMed/NCBI View Article : Google Scholar | |
Position paper: Allergen standardization and skin tests The European academy of allergology and clinical immunology. Allergy. 48:48–82. 1993.PubMed/NCBI | |
1000 Genomes Project Consortium. Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA and Abecasis GR. A global reference for human genetic variation. Nature. 526:68–74. 2015.PubMed/NCBI View Article : Google Scholar | |
Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, et al: Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 43:887–892. 2011.PubMed/NCBI View Article : Google Scholar | |
Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, et al: Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 50:42–53. 2018.PubMed/NCBI View Article : Google Scholar | |
Zhu Z, Lee PH, Chaffin MD, Chung W, Loh PR, Lu Q, Christiani DC and Liang L: A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat Genet. 50:857–864. 2018.PubMed/NCBI View Article : Google Scholar | |
Bonnelykke K, Sleiman P, Nielsen K, Kreiner-Møller E, Mercader JM, Belgrave D, den Dekker HT, Husby A, Sevelsted A, Faura-Tellez G, et al: A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet. 46:51–55. 2014.PubMed/NCBI View Article : Google Scholar | |
Barrett JC, Fry B, Maller J and Daly MJ: Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics. 21:263–265. 2005.PubMed/NCBI View Article : Google Scholar | |
Shi YY and He L: SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 15:97–98. 2005.PubMed/NCBI View Article : Google Scholar | |
Li Z, Zhang Z, He Z, Tang W, Li T, Zeng Z, He L and Shi Y: A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: Update of the SHEsis. (http://analysis.bio-x.cn). Cell Res. 19:519–523. 2009.PubMed/NCBI View Article : Google Scholar | |
Lemonnier N, Melen E, Jiang Y, Joly S, Ménard C, Aguilar D, Acosta-Perez E, Bergström A, Boutaoui N, Bustamante M, et al: A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents. Allergy 2020 (Epub ahead of print). | |
Rogala B and Gluck J: The role of interleukin-33 in rhinitis. Curr Allergy Asthma Rep. 13:196–202. 2013.PubMed/NCBI View Article : Google Scholar | |
Tomita K, Sakashita M, Hirota T, Tanaka S, Masuyama K, Yamada T, Fujieda S, Miyatake A, Hizawa N, Kubo M, et al: Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population. Allergy. 68:92–100. 2013.PubMed/NCBI View Article : Google Scholar | |
Li Y, Chen J, Rui X, Li N, Jiang F and Shen J: The association between sixteen genome-wide association studies-related allergic diseases loci and childhood allergic rhinitis in a Chinese Han population. Cytokine. 111:162–170. 2018.PubMed/NCBI View Article : Google Scholar | |
Yoon D, Ban HJ, Kim YJ, Kim EJ, Kim HC, Han BG, Park JW, Hong SJ, Cho SH, Park K and Lee JS: Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population. BMB Rep. 45:305–310. 2012.PubMed/NCBI View Article : Google Scholar | |
Amarin JZ, Naffa RG, Suradi HH, Alsaket YM, Obeidat NM, Mahafza TM and Zihlif MA: An intronic single-nucleotide polymorphism (rs13217795) in FOXO3 is associated with asthma and allergic rhinitis: A case-case-control study. BMC Med Genet. 18(132)2017.PubMed/NCBI View Article : Google Scholar | |
Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, et al: eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes. Allergy. 70:1309–1318. 2015.PubMed/NCBI View Article : Google Scholar | |
Ketelaar ME, Portelli MA, Dijk FN, Shrine N, Faiz A, Vermeulen CJ, Xu CJ, Hankinson J, Bhaker S, Henry AP, et al: Phenotypic and functional translation of IL-33 genetics in asthma. J Allergy Clin Immunol 2020 (Epub ahead of print). | |
Gorbacheva AM, Korneev KV, Kuprash DV and Mitkin NA: The risk G allele of the single-nucleotide polymorphism rs928413 creates a CREB1-Binding site that activates IL-33 promoter in lung epithelial cells. Int J Mol Sci. 19(2911)2018.PubMed/NCBI View Article : Google Scholar | |
Paller AS, Spergel JM, Mina-Osorio P and Irvine AD: The atopic march and atopic multimorbidity: Many trajectories, many pathways. J Allergy Clin Immunol. 143:46–55. 2019.PubMed/NCBI View Article : Google Scholar | |
Akdis CA, Arkwright PD, Bruggen MC, Busse W, Gadina M, Guttman-Yassky E, Kabashima K, Mitamura Y, Vian L, Wu J and Palomares O: Type 2 immunity in the skin and lungs. Allergy. 75:1582–1605. 2020.PubMed/NCBI View Article : Google Scholar | |
D'Amato G, Ortega OPM, Annesi-Maesano I and D'Amato M: Prevention of allergic asthma with allergen avoidance measures and the role of exposome. Curr Allergy Asthma Rep. 20(8)2020.PubMed/NCBI View Article : Google Scholar | |
Liccardi G, Cazzola M, Walter Canonica G, Passalacqua G and D'Amato G: New insights in allergen avoidance measures for mite and pet sensitized patients. A critical appraisal. Respir Med. 99:1363–1376. 2005.PubMed/NCBI View Article : Google Scholar | |
Halken S: Prevention of allergic disease in childhood: Clinical and epidemiological aspects of primary and secondary allergy prevention. Pediatr Allergy Immunol. 15 (Suppl 16):4–5, 9-32. 2004.PubMed/NCBI View Article : Google Scholar | |
Cook J and Saglani S: Pathogenesis and prevention strategies of severe asthma exacerbations in children. Curr Opin Pulm Med. 22:25–31. 2016.PubMed/NCBI View Article : Google Scholar | |
Chen WY, Tsai TH, Yang JL and Li LC: Therapeutic strategies for targeting IL-33/ST2 signalling for the treatment of inflammatory diseases. Cell Physiol Biochem. 49:349–358. 2018.PubMed/NCBI View Article : Google Scholar | |
Takatori H, Makita S, Ito T, Matsuki A and Nakajima H: Regulatory mechanisms of IL-33-ST2-Mediated allergic inflammation. Front Immunol. 9(2004)2018.PubMed/NCBI View Article : Google Scholar |