Antimicrobial peptides as an argument for the involvement of innate immunity in psoriasis (Review)

  • Authors:
    • Mihail Alecu
    • Gabriela Coman
    • Alina Mușetescu
    • Oana Andreia Coman
  • View Affiliations

  • Published online on: October 14, 2020     https://doi.org/10.3892/etm.2020.9322
  • Article Number: 192
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Abstract

Antimicrobial peptides (AMPs) are a group of oligopeptides found in most multicellular organisms with a capacity for rapid and nonspecific destruction of pathogens. The action of destroying pathogens is associated with a strong proinflammatory activity, stimulating the secretion of cytokines, chemokines, growth factors but also chemotaxis, the activation of dendritic cells and involving adaptive immunity also. The action of AMPs fits perfectly into the characteristics of innate immunity which makes these peptides candidates to be considered as an important element of this type of immunity. It has been shown that AMPs are involved in a number of cellular processes such as: differentiation, proliferation, maturation, thus widening the degree of involvement of these peptides in the pathogenesis of chronic inflammatory diseases. In psoriasis, AMPs act both as a pro‑inflammatory and chemotaxis factor and through the cathelicidin (LL‑37)/dc DNA complex as a possible autoantigen for T cells, triggering an autoimmune response, activating the Th17/IL23 axis and maintaining the inflammatory process. Thus, many arguments are accumulated to consider that innate immunity through AMPs is an important link in the pathogenesis of psoriasis. Moreover, the action of antimicrobial peptides in psoriasis is almost entirely characteristic for the general mode of action of innate immunity.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Alecu M, Coman G, Mușetescu A and Coman OA: Antimicrobial peptides as an argument for the involvement of innate immunity in psoriasis (Review). Exp Ther Med 20: 192, 2020
APA
Alecu, M., Coman, G., Mușetescu, A., & Coman, O.A. (2020). Antimicrobial peptides as an argument for the involvement of innate immunity in psoriasis (Review). Experimental and Therapeutic Medicine, 20, 192. https://doi.org/10.3892/etm.2020.9322
MLA
Alecu, M., Coman, G., Mușetescu, A., Coman, O. A."Antimicrobial peptides as an argument for the involvement of innate immunity in psoriasis (Review)". Experimental and Therapeutic Medicine 20.6 (2020): 192.
Chicago
Alecu, M., Coman, G., Mușetescu, A., Coman, O. A."Antimicrobial peptides as an argument for the involvement of innate immunity in psoriasis (Review)". Experimental and Therapeutic Medicine 20, no. 6 (2020): 192. https://doi.org/10.3892/etm.2020.9322