Open Access

Exercise reduces hyperlipidemia‑induced kidney damage in apolipoprotein E‑deficient mice

  • Authors:
    • Chengsi Qian
    • Qin Yang
    • Lipeng Guo
    • Hupei Zhu
    • Xi You
    • Hongyang Liu
    • Yan Sun
  • View Affiliations

  • Published online on: December 17, 2020     https://doi.org/10.3892/etm.2020.9585
  • Article Number: 153
  • Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hyperlipidemia is a risk factor of kidney damage that can lead to chronic kidney disease. Studies have shown that exercise reduces kidney damage; however, the specific mechanisms underlying the protective effects of exercise remain unclear. For 12 weeks, 8‑week‑old male apolipoprotein E‑deficient (ApoE‑/‑) mice were randomly divided into four treatment groups (n=7/group) as follows: Mice fed a normal diet (ND group); mice fed a ND and exercised (ND + E group); mice fed a high‑fat diet (HD group); and mice fed a HD and exercised (HD + E group). Exercise training consisted of swimming for 40 min, 5 days/week. Metabolic parameters, such as low‑density lipoprotein‑cholesterol, total cholesterol and creatinine levels were higher in the ApoE‑/‑ HD mice compared with those in the ApoE‑/‑ HD + E mice. Serum levels of glutathione peroxidase and superoxide dismutase were significantly decreased in the HD group compared with those in the HD + E group. Significant pathological changes were observed in the HD + E group compared with in the HD group. Immunohistochemistry and immunoblotting revealed increased levels of oxidative stress (nuclear factor erythroid‑2‑related factor 2) and fibrosis (Smad3 and TGF‑β) markers in the ApoE‑/‑ HD group; however, the expression levels of these markers were significantly decreased in the ApoE‑/‑ HD + E group. Furthermore, NF‑κB expression in the HD + E group was significantly lower compared with that in the HD group. These results suggested that exercise may exert protective effects against kidney damage caused by hyperlipidemia.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-0981
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Copy and paste a formatted citation
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Spandidos Publications style
Qian C, Yang Q, Guo L, Zhu H, You X, Liu H and Sun Y: Exercise reduces hyperlipidemia‑induced kidney damage in apolipoprotein E‑deficient mice. Exp Ther Med 21: 153, 2021.
APA
Qian, C., Yang, Q., Guo, L., Zhu, H., You, X., Liu, H., & Sun, Y. (2021). Exercise reduces hyperlipidemia‑induced kidney damage in apolipoprotein E‑deficient mice. Experimental and Therapeutic Medicine, 21, 153. https://doi.org/10.3892/etm.2020.9585
MLA
Qian, C., Yang, Q., Guo, L., Zhu, H., You, X., Liu, H., Sun, Y."Exercise reduces hyperlipidemia‑induced kidney damage in apolipoprotein E‑deficient mice". Experimental and Therapeutic Medicine 21.2 (2021): 153.
Chicago
Qian, C., Yang, Q., Guo, L., Zhu, H., You, X., Liu, H., Sun, Y."Exercise reduces hyperlipidemia‑induced kidney damage in apolipoprotein E‑deficient mice". Experimental and Therapeutic Medicine 21, no. 2 (2021): 153. https://doi.org/10.3892/etm.2020.9585