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Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)
- Authors:
- Hanna Svitina
- Josias H. Hamman
- Chrisna Gouws
-
Affiliations: Centre of Excellence for Pharmaceutical Sciences (Pharmacen™), North‑West University, Potchefstroom, North West 2520, South Africa - Published online on: June 8, 2021 https://doi.org/10.3892/etm.2021.10284
- Article Number: 852
-
Copyright: © Svitina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Majumder R, Das CK and Mandal M: Lead bioactive compounds of Aloe vera as potential anticancer agent. Pharmacol Res. 148(104416)2019.PubMed/NCBI View Article : Google Scholar | |
Sánchez M, González-Burgos E, Iglesias I and Gómez-Serranillos MP: Pharmacological update properties of Aloe vera and its major active constituents. Molecules. 25(1324)2020.PubMed/NCBI View Article : Google Scholar | |
Cristiano G, Murillo-Amador B and De Lucia B: Propagation techniques and agronomic requirements for the cultivation of barbados aloe (Aloe vera (L.) Burm. F.) - A review. Front Plant Sci. 7(1410)2016.PubMed/NCBI View Article : Google Scholar | |
Pandey A and Singh S: Aloe vera: A Systematic Review of its Industrial and Ethno-Medicinal Efficacy. Int J Pharm Res Allied Sci. 5:21–33. 2016. | |
Svitina H, Swanepoel R, Rossouw J, Netshimbupfe H, Gouws C and Hamman J: Treatment of skin disorders with Aloe materials. Curr Pharm Des. 25:2208–2240. 2019.PubMed/NCBI View Article : Google Scholar | |
Alinejad-Mofrad S, Foadoddini M, Saadatjoo SA and Shayesteh M: Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: A randomized controlled-trial. J Diabetes Metab Disord. 14(22)2015.PubMed/NCBI View Article : Google Scholar | |
Zhang Y, Liu W, Liu D, Zhao T and Tian H: Efficacy of Aloe vera supplementation on prediabetes and early non-treated diabetic patients: A systematic review and meta-analysis of randomized controlled trials. Nutrients. 8(388)2016.PubMed/NCBI View Article : Google Scholar | |
Anuradha A, Patil B and Asha VR: Evaluation of efficacy of Aloe vera in the treatment of oral submucous fibrosis - a clinical study. J Oral Pathol Med. 46:50–55. 2017.PubMed/NCBI View Article : Google Scholar | |
Ipshita S, Kurian IG, Dileep P, Kumar S, Singh P and Pradeep AR: One percent alendronate and Aloe vera gel local host modulating agents in chronic periodontitis patients with class II furcation defects: A randomized, controlled clinical trial. J Investig Clin Dent. 9(e12334)2018.PubMed/NCBI View Article : Google Scholar | |
Kurian IG, Dileep P, Ipshita S and Pradeep AR: Comparative evaluation of subgingivally-delivered 1% metformin and Aloe vera gel in the treatment of intrabony defects in chronic periodontitis patients: A randomized, controlled clinical trial. J Investig Clin Dent. 9(e12324)2018.PubMed/NCBI View Article : Google Scholar | |
Hong SW, Chun J, Park S, Lee HJ, Im JP and Kim JS: Aloe vera is effective and safe in short-term treatment of irritable bowel syndrome: A systematic review and meta-analysis. J Neurogastroenterol Motil. 24:528–535. 2018.PubMed/NCBI View Article : Google Scholar | |
Lissoni P, Rovelli F, Brivio F, Zago R, Colciago M, Messina G, Mora A and Porro G: A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer. In Vivo. 23:171–175. 2009.PubMed/NCBI | |
Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of Aloe andongensis extract, Aloe andongensis leaf juice, Aloe arborescens leaf extract, Aloe arborescens leaf juice, Aloe arborescens leaf protoplasts, Aloe barbadensis flower extract, Aloe barbadensis leaf, Aloe barbadensis leaf extract, Aloe barbadensis leaf juice, Aloe barbadensis leaf polysaccharides, Aloe barbadensis leaf water, Aloe ferox leaf extract, Aloe ferox leaf juice, and Aloe ferox leaf juice extract. Int J Toxicol. 26 (Suppl 2):S1–S50. 2007.PubMed/NCBI View Article : Google Scholar | |
Singab AN, El-Hefnawy HM, Esmat A, Gad HA and Nazeam JA: A systemic review on Aloe arborescens pharmacological profile: Biological activities and pilot clinical trials. Phytother Res. 29:1858–1867. 2015.PubMed/NCBI View Article : Google Scholar | |
Beppu H, Shimpo K, Chihara T, Tamai I, Nomoto-Yamaji S, Ozaki S, Ito S and Kuzuya H: Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets. Phytomedicine. 13:49–60. 2006.PubMed/NCBI View Article : Google Scholar | |
Aloes: The Genus Aloe. Reynolds T (ed). CRC Press LLC, p408, 2004. | |
Cock IE: The genus Aloe: Phytochemistry and therapeutic uses including treatments for gastrointestinal conditions and chronic inflammation. Prog Drug Res. 70:179–235. 2015.PubMed/NCBI View Article : Google Scholar | |
Pham DC, Shibu MA, Mahalakshmi B and Velmurugan BK: Effects of phytochemicals on cellular signaling: Reviewing their recent usage approaches. Crit Rev Food Sci Nutr. 60:3522–3546. 2020.PubMed/NCBI View Article : Google Scholar | |
Sharifi-Rad J, Kamiloglu S, Yeskaliyeva B, Beyatli A, Alfred MA, Salehi B, Calina D, Docea AO, Imran M, Anil Kumar NV, et al: Pharmacological activities of psoralidin: A comprehensive review of the molecular mechanisms of action. Front Pharmacol. 11(571459)2020.PubMed/NCBI View Article : Google Scholar | |
Battino M, Giampieri F, Cianciosi D, Ansary J, Chen X, Zhang D, Gil E and Forbes-Hernández T: The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation. Phytomedicine. 11(153170)2021.PubMed/NCBI View Article : Google Scholar | |
Alikiaii B, Bagherniya M, Askari G, Johnston TP and Sahebkar A: The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective. BioFactors. 47:19–40. 2021.PubMed/NCBI View Article : Google Scholar | |
Nobili S, Lippi D, Witort E, Donnini M, Bausi L, Mini E and Capaccioli S: Natural compounds for cancer treatment and prevention. Pharmacol Res. 59:365–378. 2009.PubMed/NCBI View Article : Google Scholar | |
Akhtar MF, Saleem A, Rasul A, Faran Ashraf Baig MM, Bin-Jumah M and Abdel Daim MM: Anticancer natural medicines: An overview of cell signaling and other targets of anticancer phytochemicals. Eur J Pharmacol. 888(173488)2020.PubMed/NCBI View Article : Google Scholar | |
Dagne E, Bisrat D, Viljoen A and van Wyk BE: Chemistry of aloe species. Cur Org Chem. 4:1055–1078. 2000. | |
Salehi B, Albayrak S, Antolak H, Kręgiel D, Pawlikowska E, Sharifi-Rad M, Uprety Y, Tsouh Fokou PV, Yousef Z, Amiruddin Zakaria Z, et al: Aloe genus plants: From farm to food applications and phytopharmacotherapy. Int J Mol Sci. 19(2843)2018.PubMed/NCBI View Article : Google Scholar | |
Mukherjee PK, Nema NK, Maity N, Mukherjee K and Harwansh RK: Phytochemical and therapeutic profile of Aloe vera. J Nat Remedies. 14:1–26. 2014. | |
Nazeam JA, Gad HA, El-Hefnawy HM and Singab AB: Chromatographic separation and detection methods of Aloe arborescens Miller constituents: A systematic review. J Chromatogr B Analyt Technol Biomed Life Sci. 1058:57–67. 2017.PubMed/NCBI View Article : Google Scholar | |
Babu SN and Noor A: Bioactive constituents of the genus Aloe and their potential therapeutic and pharmacological applications: A review. J Appl Pharm Sci. 10:133–145. 2020. | |
Arora MK, Sarup Y, Tomar R, Singh M and Kumar P: Amelioration of diabetes-induced diabetic nephropathy by Aloe vera: Implication of oxidative stress and hyperlipidemia. J Diet Suppl. 16:227–244. 2019.PubMed/NCBI View Article : Google Scholar | |
Bala S, Chugh NA, Bansal SC, Garg ML and Koul A: Radiomodulatory effects of Aloe vera on hepatic and renal tissues of X-ray irradiated mice. Mutat Res. 811:1–15. 2018.PubMed/NCBI View Article : Google Scholar | |
Sun Z, Yu C, Wang W, Yu G, Zhang T, Zhang L, Zhang J and Wei K: Aloe polysaccharides inhibit influenza a virus infection-a promising natural anti-flu drug. Front Microbiol. 9(2338)2018.PubMed/NCBI View Article : Google Scholar | |
Dou F, Liu Y, Liu L, Wang J, Sun T, Mu F, Guo Q, Guo C, Jia N, Liu W, et al: Aloe-emodin ameliorates renal fibrosis via inhibiting PI3K/Akt/mTOR signaling pathway in vivo and in vitro. Rejuvenation Res. 22:218–229. 2019.PubMed/NCBI View Article : Google Scholar | |
Tewabe Y, Kefarge B, Belay H, Bisrat D, Hailu A and Asres K: Antileishmanial evaluation of the leaf latex of Aloe macrocarpa, aloin A/B, and its semisynthetic derivatives against two leishmania species. Evid Based Complement Alternat Med. 2019(4736181)2019.PubMed/NCBI View Article : Google Scholar | |
Choi JS, Islam MN, Ali MY, Kim EJ, Kim YM and Jung HA: Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin. Food Chem Toxicol. 64:27–33. 2014.PubMed/NCBI View Article : Google Scholar | |
Choo CY, Sulong NY, Man F and Wong TW: Vitexin and isovitexin from the leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition. J Ethnopharmacol. 142:776–781. 2012.PubMed/NCBI View Article : Google Scholar | |
Guimarães CC, Oliveira DD, Valdevite M, Saltoratto AL, Pereira SI, França Sde C, Pereira AM and Pereira PS: The glycosylated flavonoids vitexin, isovitexin, and quercetrin isolated from Serjania erecta Radlk (Sapindaceae) leaves protect PC12 cells against amyloid-β25-35 peptide-induced toxicity. Food Chem Toxicol. 86:88–94. 2015.PubMed/NCBI View Article : Google Scholar | |
Trinh HA, Dam VV, Banlunara W, Sangvanich P and Thunyakitpisal P: Acemannan induced bone regeneration in lateral sinus augmentation based on cone beam computed tomographic and histopathological evaluation. Case Rep Dent. 2020(1675653)2020.PubMed/NCBI View Article : Google Scholar | |
Boonyagul S, Banlunara W, Sangvanich P and Thunyakitpisal P: Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone formation in a tooth extraction model. Odontology. 102:310–317. 2014.PubMed/NCBI View Article : Google Scholar | |
Godoy DJD, Chokboribal J, Pauwels R, Banlunara W, Sangvanich P, Jaroenporn S and Thunyakitpisal P: Acemannan increased bone surface, bone volume, and bone density in a calvarial defect model in skeletally-mature rats. J Dent Sci. 13:334–341. 2018.PubMed/NCBI View Article : Google Scholar | |
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, et al: Molecular mechanisms of cell death: Recommendations of the nomenclature committee on cell death 2018. Cell Death Differ. 25:486–541. 2018.PubMed/NCBI View Article : Google Scholar | |
Green DR and Llambi F: Cell death signaling. Cold Spring Harb Perspect Biol. 7(a006080)2015.PubMed/NCBI View Article : Google Scholar | |
Chen Q, Kang J and Fu C: The independence of and associations among apoptosis, autophagy, and necrosis. Signal Transduct Target Ther. 3(18)2018.PubMed/NCBI View Article : Google Scholar | |
Festjens N, Vanden Berghe T and Vandenabeele P: Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta. 1757:1371–1387. 2006.PubMed/NCBI View Article : Google Scholar | |
Jin Z and El-Deiry WS: Overview of cell death signaling pathways. Cancer Biol Ther. 4:139–163. 2005.PubMed/NCBI View Article : Google Scholar | |
Fox JL and MacFarlane M: Targeting cell death signalling in cancer: Minimising ‘Collateral damage’. Br J Cancer. 115:5–11. 2016.PubMed/NCBI View Article : Google Scholar | |
Redza-Dutordoir M and Averill-Bates DA: Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta. 1863:2977–2992. 2016.PubMed/NCBI View Article : Google Scholar | |
Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE and Poirier GG: Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis. Cancer Res. 53:3976–3985. 1993.PubMed/NCBI | |
Chaitanya GV, Steven AJ and Babu PP: PARP-1 cleavage fragments: Signatures of cell-death proteases in neurodegeneration. Cell Commun Signal. 8(31)2010.PubMed/NCBI View Article : Google Scholar | |
Shalabi M, Khilo K, Zakaria MM, Elsebaei MG, Abdo W and Awadin W: Anticancer activity of Aloe vera and Calligonum comosum extracts separetely on hepatocellular carcinoma cells. Asian Pac J Trop Biomed. 5:375–381. 2015. | |
Yonehara A, Tanaka Y, Kulkeaw K, Era T, Nakanishi Y and Sugiyama D: Aloe vera extract suppresses proliferation of neuroblastoma cells in vitro. Anticancer Res. 35:4479–4486. 2015.PubMed/NCBI | |
Di Luccia B, Manzo N, Vivo M, Galano E, Amoresano A, Crescenzi E, Pollice A, Tudisco R, Infascelli F and Calabrò V: A biochemical and cellular approach to explore the antiproliferative and prodifferentiative activity of Aloe arborescens leaf extract. Phytother Res. 27:1819–1828. 2013.PubMed/NCBI View Article : Google Scholar | |
Jiang X, Liu Y, Zhang G, Lin S, Wu J, Yan X, Ma Y and Ma M: Aloe-emodin induces breast tumor cell apoptosis through upregulation of miR-15a/miR-16-1 that suppresses BCL2. Evid Based Complement Alternat Med. 2020(5108298)2020.PubMed/NCBI View Article : Google Scholar | |
Du Y, Zhang J, Tao Z, Wang C, Yan S, Zhang X and Huang M: Aloe emodin exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential (∆Ψm). J BUON. 24:746–753. 2019.PubMed/NCBI | |
Cheng C and Dong W: Aloe-emodin induces endoplasmic reticulum stress-dependent apoptosis in colorectal cancer cells. Med Sci Monit. 24:6331–6339. 2018.PubMed/NCBI View Article : Google Scholar | |
Li Q, Wen J, Yu K, Shu Y, He W, Chu H, Zhang B and Ge C: Aloe-emodin induces apoptosis in human oral squamous cell carcinoma SCC15 cells. BMC Complement Altern Med. 18(296)2018.PubMed/NCBI View Article : Google Scholar | |
Byun EB, Kim HM, Sung NY, Yang MS, Kim WS, Choi D, Mushtaq S, Lee SS and Byun EH: Gamma irradiation of aloe-emodin induced structural modification and apoptosis through a ROS- and caspase-dependent mitochondrial pathway in stomach tumor cells. Int J Radiat Biol. 94:403–416. 2018.PubMed/NCBI View Article : Google Scholar | |
Shen F, Ge C and Yuan P: Aloe-emodin induces autophagy and apoptotic cell death in non-small cell lung cancer cells via Akt/mTOR and MAPK signaling. Eur J Pharmacol. 886(173550)2020.PubMed/NCBI View Article : Google Scholar | |
Arcella A, Oliva MA, Staffieri S, Sanchez M, Madonna M, Riozzi B, Esposito V, Giangaspero F and Frati L: Effects of aloe emodin on U87MG glioblastoma cell growth: In vitro and in vivo study. Environ Toxicol. 33:1160–1167. 2018.PubMed/NCBI View Article : Google Scholar | |
Yu Y, Liu H, Yang D, He F, Yuan Y, Guo J, Hu J, Yu J, Yan X, Wang S and Du Z: Aloe-emodin attenuates myocardial infarction and apoptosis via up-regulating miR-133 expression. Pharmacol Res. 146(104315)2019.PubMed/NCBI View Article : Google Scholar | |
Yaoxian W, Hui Y, Yunyan Z, Yanqin L, Xin G and Xiaoke W: Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway. Cancer Cell Int. 13(71)2013.PubMed/NCBI View Article : Google Scholar | |
Thacker PC and Karunagaran D: Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells. PLoS One. 10(e0120045)2015.PubMed/NCBI View Article : Google Scholar | |
Lin W, Zhong M, Yin H, Chen Y, Cao Q, Wang C and Ling C: Emodin induces hepatocellular carcinoma cell apoptosis through MAPK and PI3K/AKT signaling pathways in vitro and in vivo. Oncol Rep. 36:961–967. 2016.PubMed/NCBI View Article : Google Scholar | |
Dong X, Ni B, Fu J, Yin X, You L, Leng X, Liang X and Ni J: Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase-dependent pathway. Oncol Rep. 40:1985–1993. 2018.PubMed/NCBI View Article : Google Scholar | |
Zhang L, He D, Li K, Liu H, Wang B, Zheng L and Li J: Emodin targets mitochondrial cyclophilin D to induce apoptosis in HepG2 cells. Biomed Pharmacother. 90:222–228. 2017.PubMed/NCBI View Article : Google Scholar | |
Liu DL, Bu H, Li H, Chen H, Guo HC, Wang ZH, Tong HF, Ni ZL, Liu HB and Lin SZ: Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro. Int J Oncol. 40:1049–1057. 2012.PubMed/NCBI View Article : Google Scholar | |
Su YT, Chang HL, Shyue SK and Hsu SL: Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochem Pharmacol. 70:229–241. 2005.PubMed/NCBI View Article : Google Scholar | |
Lai JM, Chang JT, Wen CL and Hsu SL: Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells. Eur J Pharmacol. 623:1–9. 2009.PubMed/NCBI View Article : Google Scholar | |
Huang FJ, Hsuuw YD and Chan WH: Characterization of apoptosis induced by emodin and related regulatory mechanisms in human neuroblastoma cells. Int J Mol Sci. 14:20139–20156. 2013.PubMed/NCBI View Article : Google Scholar | |
Pooja T and Karunagaran D: Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620. Eur J Pharmacol. 742:55–64. 2014.PubMed/NCBI View Article : Google Scholar | |
Wei WT, Chen H, Ni ZL, Liu HB, Tong HF, Fan L, Liu A, Qiu MX, Liu DL, Guo HC, et al: Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation. Int J Oncol. 39:1381–1390. 2011.PubMed/NCBI View Article : Google Scholar | |
Ren L, Li Z, Dai C, Zhao D, Wang Y, Ma C and Liu C: Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines. Mol Med Rep. 17:4376–4382. 2018.PubMed/NCBI View Article : Google Scholar | |
Zhang J, Wang Q, Wang Q, Guo P, Wang Y, Xing Y, Zhang M, Liu F and Zeng Q: Chrysophanol exhibits anti-cancer activities in lung cancer cell through regulating ROS/HIF-1a/VEGF signaling pathway. Naunyn Schmiedebergs Arch Pharmacol. 393:469–480. 2020.PubMed/NCBI View Article : Google Scholar | |
Park S, Lim W and Song G: Chrysophanol selectively represses breast cancer cell growth by inducing reactive oxygen species production and endoplasmic reticulum stress via AKT and mitogen-activated protein kinase signal pathways. Toxicol Appl Pharmacol. 360:201–211. 2018.PubMed/NCBI View Article : Google Scholar | |
Lu CC, Yang JS, Huang AC, Hsia TC, Chou ST, Kuo CL, Lu HF, Lee TH, Wood WG and Chung JG: Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol Nutr Food Res. 54:967–976. 2010.PubMed/NCBI View Article : Google Scholar | |
Ni CH, Yu CS, Lu HF, Yang JS, Huang HY, Chen PY, Wu SH, Ip SW, Chiang SY, Lin JG and Chung JG: Chrysophanol-induced cell death (necrosis) in human lung cancer A549 cells is mediated through increasing reactive oxygen species and decreasing the level of mitochondrial membrane potential. Environ Toxicol. 29:740–749. 2014.PubMed/NCBI View Article : Google Scholar | |
Lim W, Yang C, Bazer FW and Song G: Chrysophanol induces apoptosis of choriocarcinoma through regulation of ROS and the AKT and ERK1/2 pathways. J Cell Physiol. 232:331–339. 2017.PubMed/NCBI View Article : Google Scholar | |
Choi JS: Chrysophanic acid induces necrosis but not necroptosis in human renal cell carcinoma Caki-2 cells. J Cancer Prev. 21:81–87. 2016.PubMed/NCBI View Article : Google Scholar | |
Wang Z, Tang T, Wang S, Cai T, Tao H, Zhang Q, Qi S and Qi Z: Aloin inhibits the proliferation and migration of gastric cancer cells by regulating NOX2-ROS-mediated pro-survival signal pathways. Drug Des Devel Ther. 14:145–155. 2020.PubMed/NCBI View Article : Google Scholar | |
Tao H, Tang T, Wang S, Wang Z, Ma Y, Cai T, Cheng X, Qi S, Zhang Y and Qi Z: The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1. Drug Des Devel Ther. 13:1221–1231. 2019.PubMed/NCBI View Article : Google Scholar | |
Sun R, Zhai R, Ma C and Miao W: Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway. Cancer Med. 9:1141–1151. 2020.PubMed/NCBI View Article : Google Scholar | |
Wan L, Zhang L, Fan K and Wang J: Aloin promotes A549 cell apoptosis via the reactive oxygen species-mitogen activated protein kinase signaling pathway and p53 phosphorylation. Mol Med Rep. 16:5759–5768. 2017.PubMed/NCBI View Article : Google Scholar | |
Pan Q, Pan H, Lou H, Xu Y and Tian L: Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo. Cancer Cell Int. 13(69)2013.PubMed/NCBI View Article : Google Scholar | |
Ma Y, Tang T, Sheng L, Wang Z, Tao H, Zhang Q, Zhang Y and Qi Z: Aloin suppresses lipopolysaccharide-induced inflammation by inhibiting JAK1-STAT1/3 activation and ROS production in RAW264.7 cells. Int J Mol Med. 42:1925–1934. 2018.PubMed/NCBI View Article : Google Scholar | |
Jiang K, Guo S, Yang C, Yang J, Chen Y, Shaukat A, Zhao G, Wu H and Deng G: Barbaloin protects against lipopolysaccharide (LPS)-induced acute lung injury by inhibiting the ROS-mediated PI3K/AKT/NF-κB pathway. Int Immunopharmacol. 64:140–150. 2018.PubMed/NCBI View Article : Google Scholar | |
Luo X, Zhang H, Wei X, Shi M, Fan P, Xie W, Zhang Y and Xu N: Aloin suppresses lipopolysaccharide-induced inflammatory response and apoptosis by inhibiting the activation of NF-κB. Molecules. 23(517)2018.PubMed/NCBI View Article : Google Scholar | |
Du Y, Qian B, Gao L, Tan P, Chen H, Wang A, Zheng T, Pu S, Xia X and Fu W: Aloin preconditioning attenuates hepatic ischemia/reperfusion injury via inhibiting TLR4/MyD88/NF-κB signal pathway in vivo and in vitro. Oxid Med Cell Longev. 2019(3765898)2019.PubMed/NCBI View Article : Google Scholar | |
Zhang LQ, Lv RW, Qu XD, Chen XJ, Lu HS and Wang Y: Aloesin suppresses cell growth and metastasis in ovarian cancer SKOV3 cells through the inhibition of the MAPK signaling pathway. Anal Cell Pathol (Amst). 2017(8158254)2017.PubMed/NCBI View Article : Google Scholar | |
Arora R, Sawney S, Saini V, Steffi C, Tiwari M and Saluja D: Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1. Mol Cancer. 15(64)2016.PubMed/NCBI View Article : Google Scholar | |
Turkekul K, Colpan RD, Baykul T, Ozdemir MD and Erdogan S: Esculetin inhibits the survival of human prostate cancer cells by inducing apoptosis and arresting the cell cycle. J Cancer Prev. 23:10–17. 2018.PubMed/NCBI View Article : Google Scholar | |
Wang G, Lu M, Yao Y, Wang J and Li J: Esculetin exerts antitumor effect on human gastric cancer cells through IGF-1/PI3K/Akt signaling pathway. Eur J Pharmacol. 814:207–215. 2017.PubMed/NCBI View Article : Google Scholar | |
Li J, Li S, Wang X and Wang H: Esculetin induces apoptosis of SMMC-7721 cells through IGF-1/PI3K/Akt-mediated mitochondrial pathways. Can J Physiol Pharmacol. 95:787–794. 2017.PubMed/NCBI View Article : Google Scholar | |
Wang X, Huang S, Xin X, Ren Y, Weng G and Wang P: The antitumor activity of umbelliferone in human renal cell carcinoma via regulation of the p110γ catalytic subunit of PI3Kγ. Acta Pharm. 69:111–119. 2019.PubMed/NCBI View Article : Google Scholar | |
Zhang G, Xu Y and Zhou HF: Esculetin inhibits proliferation, invasion, and migration of laryngeal cancer in vitro and in vivo by inhibiting Janus kinas (JAK)-signal transducer and activator of transcription-3 (STAT3) activation. Med Sci Monit. 25:7853–7863. 2019.PubMed/NCBI View Article : Google Scholar | |
Vijayalakshmi A and Sindhu G: Umbelliferone arrest cell cycle at G0/G1 phase and induces apoptosis in human oral carcinoma (KB) cells possibly via oxidative DNA damage. Biomed Pharmacother. 92:661–671. 2017.PubMed/NCBI View Article : Google Scholar | |
Lv SX and Qiao X: Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. Biochem Biophys Res Commun. 496:1047–1054. 2018.PubMed/NCBI View Article : Google Scholar | |
Girish TK, Kumar KA and Prasada Rao UJS: C-Glycosylated flavonoids from black gram husk: Protection against DNA and erythrocytes from oxidative damage and their cytotoxic effect on HeLa cells. Toxicol Rep. 3:652–663. 2016.PubMed/NCBI View Article : Google Scholar | |
Lv H, Yu Z, Zheng Y, Wang L, Qin X, Cheng G and Ci X: Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-κB and activating HO-1/Nrf2 pathways. Int J Biol Sci. 12:72–86. 2016.PubMed/NCBI View Article : Google Scholar | |
Stegh AH: Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils. Expert Opin Ther Targets. 16:67–83. 2012.PubMed/NCBI View Article : Google Scholar | |
Hosseini MS, Hosseini F, Ahmadi A, Mozafari M and Amjadi I: Antiproliferative activity of Hypericum perforatum, Achillea millefolium, and Aloe vera in interaction with the prostatic activity of CD82. Rep Biochem Mol Biol. 8:260–268. 2019.PubMed/NCBI | |
Majumder R, Parida P, Paul S and Basak P: In vitro and in silico study of Aloe vera leaf extract against human breast cancer. Nat Prod Res. 34:2363–2366. 2020.PubMed/NCBI View Article : Google Scholar | |
Leng H, Pu L, Xu L, Shi X, Ji J and Chen K: Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF-α-induced HaCaT cell proliferation and the underlying mechanism in psoriasis. Mol Med Rep. 18:3537–3543. 2018.PubMed/NCBI View Article : Google Scholar | |
Ozenver N, Saeed M, Demirezer LO and Efferth T: Aloe-emodin as drug candidate for cancer therapy. Oncotarget. 9:17770–17796. 2018.PubMed/NCBI View Article : Google Scholar | |
Liu C: Inhibition of mechanical stress-induced hypertrophic scar inflammation by emodin. Mol Med Rep. 11:4087–4092. 2015.PubMed/NCBI View Article : Google Scholar | |
Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC and Liu DL: Antitumor activity of emodin against pancreatic cancer depends on its dual role: Promotion of apoptosis and suppression of angiogenesis. PLoS One. 7(e42146)2012.PubMed/NCBI View Article : Google Scholar | |
Youn DH, Park J, Kim HL, Jung Y, Kang J, Jeong MY, Sethi G, Seok Ahn K and Um JY: Chrysophanic acid reduces testosterone-induced benign prostatic hyperplasia in rats by suppressing 5α-reductase and extracellular signal-regulated kinase. Oncotarget. 8:9500–9512. 2017.PubMed/NCBI View Article : Google Scholar | |
Lee IC and Bae JS: Suppressive effects of aloin on polyphosphate-mediated vascular inflammatory responses. J Asian Nat Prod Res. 23:89–99. 2021.PubMed/NCBI View Article : Google Scholar | |
Lee IC and Bae JS: Inhibitory effects of aloin on TGFBIp-mediated septic responses. J Asian Nat Prod Res. 23:189–203. 2021.PubMed/NCBI View Article : Google Scholar | |
Barnum KJ and O'Connell MJ: Cell cycle regulation by checkpoints. Methods Mol Biol. 1170:29–40. 2014.PubMed/NCBI View Article : Google Scholar | |
Poon RY: Cell cycle control: A system of interlinking oscillators. Methods Mol Biol. 1342:3–19. 2016.PubMed/NCBI View Article : Google Scholar | |
Zhang J, Guo L, Zhang Q, Liu K and Dong Z: Aloe emodin suppresses EGF-induced neoplastic cell transformation by inhibiting the ERK/MSK1 and AKT/GSK3β signaling pathways. Mol Med Rep. 18:5215–5220. 2018.PubMed/NCBI View Article : Google Scholar | |
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY and Lin H: Emodin and Aloe-emodin suppress breast cancer cell proliferation through ER α inhibition. Evid Based Complement Alternat Med. 2013(376123)2013.PubMed/NCBI View Article : Google Scholar | |
Lee KY, Park JH, Chung MH, Park YI, Kim KW, Lee YJ and Lee SK: Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells. Biochem Mol Biol Int. 41:285–292. 1997.PubMed/NCBI View Article : Google Scholar | |
Fan X, Du H, Sun Y, Jiang J, Wang Z, Yin W, Fan K and Li H: Suppression of the Wnt signaling pathway may contribute to the inhibition of proliferation of human hepatocellular carcinoma SMMC-7721 cells by esculetin. Oncol Lett. 14:1731–1736. 2017.PubMed/NCBI View Article : Google Scholar | |
Xing W, Guo W, Zou CH, Fu TT, Li XY, Zhu M, Qi JH, Song J, Dong CH, Li Z, et al: Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway. J Dermatol Sci. 79:101–109. 2015.PubMed/NCBI View Article : Google Scholar | |
Altomare DA and Testa JR: Perturbations of the AKT signaling pathway in human cancer. Oncogene. 24:7455–7464. 2005.PubMed/NCBI View Article : Google Scholar | |
Manning BD and Toker A: AKT/PKB Signaling: Navigating the network. Cell. 169:381–405. 2017.PubMed/NCBI View Article : Google Scholar | |
Madhunapantula SV, Mosca PJ and Robertson GP: The Akt signaling pathway: An emerging therapeutic target in malignant melanoma. Cancer Biol Ther. 12:1032–1049. 2011.PubMed/NCBI View Article : Google Scholar | |
Nakanishi K, Sakamoto M, Yamasaki S, Todo S and Hirohashi S: Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma. Cancer. 103:307–312. 2005.PubMed/NCBI View Article : Google Scholar | |
Kunter I, Erdal E, Nart D, Yilmaz F, Karademir S, Sagol O and Atabey N: Active form of AKT controls cell proliferation and response to apoptosis in hepatocellular carcinoma. Oncol Rep. 31:573–580. 2014.PubMed/NCBI View Article : Google Scholar | |
Kim MS, Park MJ, Kim SJ, Lee CH, Yoo H, Shin SH, Song ES and Lee SH: Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells. Int J Oncol. 27:839–846. 2005.PubMed/NCBI | |
Deng M, Xue YJ, Xu LR, Wang QW, Wei J, Ke XQ, Wang JC and Chen XD: Chrysophanol suppresses hypoxia-induced epithelial-mesenchymal transition in colorectal cancer cells. Anat Rec (Hoboken). 302:1561–1570. 2019.PubMed/NCBI View Article : Google Scholar | |
Lee MS, Cha EY, Sul JY, Song IS and Kim JY: Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 25:833–837. 2011.PubMed/NCBI View Article : Google Scholar | |
Pencik J, Pham HT, Schmoellerl J, Javaheri T, Schlederer M, Culig Z, Merkel O, Moriggl R, Grebien F and Kenner L: JAK-STAT signaling in cancer: From cytokines to non-coding genome. Cytokine. 87:26–36. 2016.PubMed/NCBI View Article : Google Scholar | |
Verhoeven Y, Tilborghs S, Jacobs J, De Waele J, Quatannens D, Deben C, Prenen H, Pauwels P, Trinh XB, Wouters A, et al: The potential and controversy of targeting STAT family members in cancer. Semin Cancer Biol. 60:41–56. 2020.PubMed/NCBI View Article : Google Scholar | |
Hin Tang JJ, Hao Thng DK, Lim JJ and Toh TB: JAK/STAT signaling in hepatocellular carcinoma. Hepat Oncol. 7(HEP18)2020.PubMed/NCBI View Article : Google Scholar | |
Harrison DA: The Jak/STAT pathway. Cold Spring Harb Perspect Biol. 4(a011205)2012.PubMed/NCBI View Article : Google Scholar | |
Kiu H and Nicholson SE: Biology and significance of the JAK/STAT signalling pathways. Growth Factors. 30:88–106. 2012.PubMed/NCBI View Article : Google Scholar | |
Lee W, Yang S, Lee C, Park EK, Kim KM, Ku SK and Bae JS: Aloin reduces inflammatory gene iNOS via inhibition activity and p-STAT-1 and NF-κB. Food Chem Toxicol. 126:67–71. 2019.PubMed/NCBI View Article : Google Scholar | |
Lin H, Honglang L, Weifeng L, Junmin C, Jiantao Y and Junjing G: The mechanism of alopolysaccharide protecting ulceralive colitis. Biomed Pharmacother. 88:145–150. 2017.PubMed/NCBI View Article : Google Scholar | |
Guo YJ, Pan WW, Liu SB, Shen ZF, Xu Y and Hu LL: ERK/MAPK signalling pathway and tumorigenesis. Exp Ther Med. 19:1997–2007. 2020.PubMed/NCBI View Article : Google Scholar | |
McCain J: The MAPK (ERK) pathway: Investigational combinations for the treatment of BRAF- mutated metastatic melanoma. P T. 38:96–108. 2013.PubMed/NCBI | |
Zhang W and Liu HT: MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 12:9–18. 2002.PubMed/NCBI View Article : Google Scholar | |
Li P, Kong J, Chen Z, Huang S, Lv G, Wei B, Wei J, Jing K, Quan J and Chu J: Aloin promotes osteogenesis of bone-marrow-derived mesenchymal stem cells via the ERK1/2-dependent Runx2 signaling pathway. J Nat Med. 73:104–113. 2019.PubMed/NCBI View Article : Google Scholar | |
Zhong J, Wang F, Wang Z, Shen C, Zheng Y, Ma F, Zhu T, Chen L, Tang Q and Zhu J: Aloin attenuates cognitive impairment and inflammation induced by d-galactose via down-regulating ERK, p38 and NF-κB signaling pathway. Int Immunopharmacol. 72:48–54. 2019.PubMed/NCBI View Article : Google Scholar | |
Wahedi HM, Jeong M, Chae JK, Do SG, Yoon H and Kim SY: Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. Phytomedicine. 28:19–26. 2017.PubMed/NCBI View Article : Google Scholar | |
Wagner EF and Nebreda ÁR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 9:537–549. 2009.PubMed/NCBI View Article : Google Scholar | |
Zhou YY, Li Y, Jiang WQ and Zhou LF: MAPK/JNK signalling: A potential autophagy regulation pathway. Biosci Rep. 35(e00199)2015.PubMed/NCBI View Article : Google Scholar | |
Chen Q, Li KT, Tian S, Yu TH, Yu LH, Lin HD and Bai DQ: Photodynamic therapy mediated by aloe-emodin inhibited angiogenesis and cell metastasis through activating MAPK signaling pathway on HUVECs. Technol Cancer Res Treat. 17(1533033818785512)2018.PubMed/NCBI View Article : Google Scholar | |
Yin JT, Wan B, Liu DD, Wan SX, Fu HY, Wan Y, Zhang H and Chen Y: Emodin alleviates lung injury in rats with sepsis. J Surg Res. 202:308–314. 2016.PubMed/NCBI View Article : Google Scholar | |
Lee W, Jeong GS, Baek MC, Ku SK and Bae JS: Renal protective effects of aloin in a mouse model of sepsis. Food Chem Toxicol. 132(110651)2019.PubMed/NCBI View Article : Google Scholar | |
Penn JW, Grobbelaar AO and Rolfe KJ: The role of the TGF-β family in wound healing, burns and scarring: A review. Int J Burns Trauma. 2:18–28. 2012.PubMed/NCBI | |
Barrientos S, Stojadinovic O, Golinko MS, Brem H and Tomic-Canic M: Growth factors and cytokines in wound healing. Wound Repair Regen. 16:585–601. 2008.PubMed/NCBI View Article : Google Scholar | |
Creeden J, Ong S, Gillman C, Atkinson R, Stanbery L, Dworkin L and Nemunaitis J: The Role of TGFβ in Clinical Cancer Response. Clin Oncol Res. 2020:1–8. 2020. | |
Chaudhury A and Howe PH: The tale of transforming growth factor-beta (TGFbeta) signaling: A soigné enigma. IUBMB Life. 61:929–939. 2009.PubMed/NCBI View Article : Google Scholar | |
Calone I and Souchelnytskyi S: Inhibition of TGFβ signaling and its implications in anticancer treatments. Exp Oncol. 34:9–16. 2012.PubMed/NCBI | |
Hormozi M, Assaei R and Boroujeni MB: The effect of Aloe vera on the expression of wound healing factors (TGFβ1 and bFGF) in mouse embryonic fibroblast cell: In vitro study. Biomed Pharmacother. 88:610–616. 2017.PubMed/NCBI View Article : Google Scholar | |
Takzaree N, Hadjiakhondi A, Hassanzadeh G, Rouini MR, Manayi A and Zolbin MM: Transforming growth factor-β (TGF-β) activation in cutaneous wounds after topical application of Aloe vera gel. Can J Physiol Pharmacol. 94:1285–1290. 2016.PubMed/NCBI View Article : Google Scholar | |
Zhang LJ, Huang XJ, Shi XD, Chen HH, Cui SW and Nie SP: Protective effect of three glucomannans from different plants against DSS induced colitis in female BALB/c mice. Food Funct. 10:1928–1939. 2019.PubMed/NCBI View Article : Google Scholar | |
Klaus A and Birchmeier W: Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 8:387–398. 2008.PubMed/NCBI View Article : Google Scholar | |
MacDonald BT, Tamai K and He X: Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell. 17:9–26. 2009.PubMed/NCBI View Article : Google Scholar | |
Komiya Y and Habas R: Wnt signal transduction pathways. Organogenesis. 4:68–75. 2008.PubMed/NCBI View Article : Google Scholar | |
Peng C, Zhang W, Shen X, Yuan Y, Li Y, Zhang W and Yao M: Post-transcriptional regulation activity through alternative splicing involved in the effects of Aloe vera on the Wnt/β-catenin and Notch pathways in colorectal cancer cells. J Pharmacol Sci. 143:148–155. 2020.PubMed/NCBI View Article : Google Scholar | |
Peng C, Zhang W, Dai C, Li W, Shen X, Yuan Y, Yan L, Zhang W and Yao M: Study of the aqueous extract of Aloe vera and its two active components on the Wnt/β-catenin and Notch signaling pathways in colorectal cancer cells. J Ethnopharmacol. 243(112092)2019.PubMed/NCBI View Article : Google Scholar | |
Nishida N, Yano H, Nishida T, Kamura T and Kojiro M: Angiogenesis in cancer. Vasc Health Risk Manag. 2:213–219. 2006.PubMed/NCBI View Article : Google Scholar | |
Kerbel RS: Tumor angiogenesis. N Engl J Med. 358:2039–2049. 2008.PubMed/NCBI View Article : Google Scholar | |
Kocik J, Bałan BJ, Zdanowski R, Jung L, Skopińska-Rózewska E and Skopiński P: Feeding mice with Aloe vera gel diminishes L-1 sarcoma-induced early neovascular response and tumor growth. Cent Eur J Immunol. 39:14–18. 2014.PubMed/NCBI View Article : Google Scholar | |
Prakoso YA and Kurniasih : The effects of Aloe vera cream on the expression of CD4+ and CD8+ lymphocytes in skin wound healing. J Trop Med. 2018(6218303)2018.PubMed/NCBI View Article : Google Scholar | |
Negahdari S, Galehdari H, Kesmati M, Rezaie A and Shariati G: Wound healing activity of extracts and formulations of Aloe vera, henna, Adiantum capillus-veneris, and myrrh on mouse dermal fibroblast cells. Int J Prev Med. 8(18)2017.PubMed/NCBI View Article : Google Scholar | |
Lin LX, Wang P, Wang YT, Huang Y, Jiang L and Wang XM: Aloe vera and Vitis vinifera improve wound healing in an in vivo rat burn wound model. Mol Med Rep. 13:1070–1076. 2016.PubMed/NCBI View Article : Google Scholar | |
Chen YK, Xu YK, Zhang H, Yin JT, Fan X, Liu DD, Fu HY and Wan B: Emodin alleviates jejunum injury in rats with sepsis by inhibiting inflammation response. Biomed Pharmacother. 84:1001–1007. 2016.PubMed/NCBI View Article : Google Scholar | |
Songsiripradubboon S, Kladkaew S, Trairatvorakul C, Sangvanich P, Soontornvipart K, Banlunara W and Thunyakitpisal P: Stimulation of dentin regeneration by using acemannan in teeth with lipopolysaccharide-induced pulp inflammation. J Endod. 43:1097–1103. 2017.PubMed/NCBI View Article : Google Scholar | |
Jettanacheawchankit S, Sasithanasate S, Sangvanich P, Banlunara W and Thunyakitpisal P: Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing. J Pharmacol Sci. 109:525–531. 2009.PubMed/NCBI View Article : Google Scholar | |
Rosen RD and Sapra A: TNM Classification. In: StatPearls - [Internet]. StatPearls Publishing, Treasure Island, FL, 2021. https://www.ncbi.nlm.nih.gov/books/NBK553187/. Accessed February 23, 2021. | |
Krakhmal NV, Zavyalova MV, Denisov EV, Vtorushin SV and Perelmuter VM: Cancer invasion: Patterns and mechanisms. Acta Naturae. 7:17–28. 2015.PubMed/NCBI | |
Feng J, Huang C, Wren JD, Wang DW, Yan J, Zhang J, Sun Y, Han X and Zhang XA: Tetraspanin CD82: A suppressor of solid tumors and a modulator of membrane heterogeneity. Cancer Metastasis Rev. 34:619–633. 2015.PubMed/NCBI View Article : Google Scholar | |
Prabhu VV and Devaraj SN: KAI1/CD82, metastasis suppressor gene as a therapeutic target for non-small-cell lung carcinoma. J Environ Pathol Toxicol Oncol. 36:269–275. 2017.PubMed/NCBI View Article : Google Scholar | |
Wang X and Lin Y: Tumor necrosis factor and cancer, buddies or foes? Acta Pharmacol Sin. 29:1275–1288. 2008.PubMed/NCBI View Article : Google Scholar | |
van Horssen R, Ten Hagen TL and Eggermont AM: TNF-alpha in cancer treatment: Molecular insights, antitumor effects, and clinical utility. Oncologist. 11:397–408. 2006.PubMed/NCBI View Article : Google Scholar | |
Montfort A, Colacios C, Levade T, Andrieu-Abadie N, Meyer N and Ségui B: The TNF paradox in cancer progression and immunotherapy. Front Immunol. 10(1818)2019.PubMed/NCBI View Article : Google Scholar | |
Katsuyama K, Shichiri M, Marumo F and Hirata Y: NO inhibits cytokine-induced iNOS expression and NF-kappaB activation by interfering with phosphorylation and degradation of IkappaB-alpha. Arterioscler Thromb Vasc Biol. 18:1796–1802. 1998.PubMed/NCBI View Article : Google Scholar | |
Holbrook J, Lara-Reyna S, Jarosz-Griffiths H and McDermott M: Tumour necrosis factor signalling in health and disease. F1000Res. 8(F1000 Faculty Rev-111)2019.PubMed/NCBI View Article : Google Scholar | |
Luo S, Deng X, Liu Q, Pan Z, Zhao Z, Zhou L and Luo X: Emodin ameliorates ulcerative colitis by the flagellin-TLR5 dependent pathway in mice. Int Immunopharmacol. 59:269–275. 2018.PubMed/NCBI View Article : Google Scholar | |
Hamiza OO, Rehman MU, Khan R, Tahir M, Khan AQ, Lateef A and Sultana S: Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats. Hum Exp Toxicol. 33:148–163. 2014.PubMed/NCBI View Article : Google Scholar | |
Habeeb F, Stables G, Bradbury F, Nong S, Cameron P, Plevin R and Ferro VA: The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. Methods. 42:388–393. 2007.PubMed/NCBI View Article : Google Scholar | |
Duansak D, Somboonwong J and Patumraj S: Effects of Aloe vera on leukocyte adhesion and TNF-alpha and IL-6 levels in burn wounded rats. Clin Hemorheol Microcirc. 29:239–246. 2003.PubMed/NCBI | |
Chen Y, Feng B, Yuan Y, Hu J, Zhao W, Jiang H, Li W, Fan Z and Du Z: Aloe emodin reduces cardiac inflammation induced by a high-fat diet through the TLR4 signaling pathway. Mediators Inflamm. 2020(6318520)2020.PubMed/NCBI View Article : Google Scholar | |
Deshmane SL, Kremlev S, Amini S and Sawaya BE: Monocyte chemoattractant protein-1 (MCP-1): An overview. J Interf Cytokine Res. 29:313–326. 2009.PubMed/NCBI View Article : Google Scholar | |
Pengjam Y, Madhyastha H, Madhyastha R, Yamaguchi Y, Nakajima Y and Maruyama M: NF-κB pathway inhibition by anthrocyclic glycoside aloin is key event in preventing osteoclastogenesis in RAW264.7 cells. Phytomedicine. 23:417–428. 2016.PubMed/NCBI View Article : Google Scholar | |
Hu JJ, Wang H, Pan CW and Lin MX: Isovitexin alleviates liver injury induced by lipopolysaccharide/D-galactosamine by activating Nrf2 and inhibiting NF-κB activation. Microb Pathog. 119:86–92. 2018.PubMed/NCBI View Article : Google Scholar | |
Im SA, Oh ST, Song S, Kim MR, Kim DS, Woo SS, Jo TH, Park YI and Lee CK: Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity. Int Immunopharmacol. 5:271–279. 2005.PubMed/NCBI View Article : Google Scholar | |
Thunyakitpisal P, Ruangpornvisuti V, Kengkwasing P, Chokboribal J and Sangvanich P: Acemannan increases NF-κB/DNA binding and IL-6/-8 expression by selectively binding Toll-like receptor-5 in human gingival fibroblasts. Carbohydr Polym. 161:149–157. 2017.PubMed/NCBI View Article : Google Scholar | |
Pugh N, Ross SA, ElSohly MA and Pasco DS: Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J Agric Food Chem. 49:1030–1034. 2001.PubMed/NCBI View Article : Google Scholar | |
Karaca K, Sharma JM and Nordgren R: Nitric oxide production by chicken macrophages activated by Acemannan, a complex carbohydrate extracted from Aloe vera. Int J Immunopharmacol. 17:183–188. 1995.PubMed/NCBI View Article : Google Scholar | |
Lee JK, Lee MK, Yun YP, Kim Y, Kim JS, Kim YS, Kim K, Han SS and Lee CK: Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells. Int Immunopharmacol. 1:1275–1284. 2001.PubMed/NCBI View Article : Google Scholar | |
Zhang L and Tizard IR: Activation of a mouse macrophage cell line by acemannan: The major carbohydrate fraction from Aloe vera gel. Immunopharmacology. 35:119–128. 1996.PubMed/NCBI View Article : Google Scholar | |
Liu S, Zhang X and Wang J: Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses. Int Immunopharmacol. 83(106437)2020.PubMed/NCBI View Article : Google Scholar |