Open Access

Role of m6A in osteoporosis, arthritis and osteosarcoma (Review)

  • Authors:
    • Yibo Hu
    • Xiaohui Zhao
  • View Affiliations

  • Published online on: June 30, 2021     https://doi.org/10.3892/etm.2021.10358
  • Article Number: 926
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

RNA modification is a type of post‑transcriptional modification that regulates important cellular pathways, such as the processing and metabolism of RNA. The most abundant form of methylation modification is RNA N6‑methyladenine (m6A), which plays various post‑transcriptional regulatory roles in cellular biological functions, including cell differentiation, embryonic development and disease occurrence. Bones play a pivotal role in the skeletal system as they support and protect muscles and other organs, facilitate movement and ensure haematopoiesis. The development and remodelling of bones require a delicate and accurate regulation of gene expression by epigenetic mechanisms that involve modifications of histone, DNA and RNA. The present review discusses the enzymes and proteins involved in mRNA m6A methylation modification and summarises current research progress and the mechanisms of mRNA m6A methylation in common orthopaedic diseases, including osteoporosis, arthritis and osteosarcoma.
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September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hu Y and Zhao X: Role of m6A in osteoporosis, arthritis and osteosarcoma (Review). Exp Ther Med 22: 926, 2021.
APA
Hu, Y., & Zhao, X. (2021). Role of m6A in osteoporosis, arthritis and osteosarcoma (Review). Experimental and Therapeutic Medicine, 22, 926. https://doi.org/10.3892/etm.2021.10358
MLA
Hu, Y., Zhao, X."Role of m6A in osteoporosis, arthritis and osteosarcoma (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 926.
Chicago
Hu, Y., Zhao, X."Role of m6A in osteoporosis, arthritis and osteosarcoma (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 926. https://doi.org/10.3892/etm.2021.10358