Open Access

Hypersensitivity reactions to monoclonal antibodies: Classification and treatment approach (Review)

  • Authors:
    • Irena Pintea
    • Carina Petricau
    • Dinu Dumitrascu
    • Adriana Muntean
    • Daniel Constantin Branisteanu
    • Daciana Elena Branisteanu
    • Diana Deleanu
  • View Affiliations

  • Published online on: July 3, 2021     https://doi.org/10.3892/etm.2021.10381
  • Article Number: 949
  • Copyright: © Pintea et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present paper aims to review the topic of adverse reactions to biological agents, in terms of the incriminating mechanisms and therapeutic approach. As a result of immunomodulatory therapy, the last decade has achieved spectacular results in the targeted treatment of inflammatory, autoimmune, and neoplastic diseases, to name a few. The widespread use of biological agents is, however, associated with an increase in the number of observed adverse drug reactions ranging from local erythema to systemic reactions, including life‑threatening immunologically mediated events, which justifies the need for a deeper understanding of this subject. Rapid desensitization to biological agents emerges as a treatment strategy for anaphylactic (immediate or delayed) hypersensitivity reactions as well as for severe infusion reactions. Drug desensitization is the administration of progressively increasing doses of the specific preparation until reaching the therapeutic dose in order to induce immunological tolerance and is indicated when the drugs are indispensable to the therapeutic regimen of individuals with hypersensitivity reactions to the preparation, with no reasonable alternatives.
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September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Pintea I, Petricau C, Dumitrascu D, Muntean A, Branisteanu DC, Branisteanu DE and Deleanu D: Hypersensitivity reactions to monoclonal antibodies: Classification and treatment approach (Review). Exp Ther Med 22: 949, 2021.
APA
Pintea, I., Petricau, C., Dumitrascu, D., Muntean, A., Branisteanu, D.C., Branisteanu, D.E., & Deleanu, D. (2021). Hypersensitivity reactions to monoclonal antibodies: Classification and treatment approach (Review). Experimental and Therapeutic Medicine, 22, 949. https://doi.org/10.3892/etm.2021.10381
MLA
Pintea, I., Petricau, C., Dumitrascu, D., Muntean, A., Branisteanu, D. C., Branisteanu, D. E., Deleanu, D."Hypersensitivity reactions to monoclonal antibodies: Classification and treatment approach (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 949.
Chicago
Pintea, I., Petricau, C., Dumitrascu, D., Muntean, A., Branisteanu, D. C., Branisteanu, D. E., Deleanu, D."Hypersensitivity reactions to monoclonal antibodies: Classification and treatment approach (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 949. https://doi.org/10.3892/etm.2021.10381