Open Access

MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α

  • Authors:
    • Nengjing Gong
    • Xiaohuai Yang
    • Xiaoyu Li
    • Yuyu Jiang
    • Cuifang Gu
    • Shasha Ma
    • Qin Gao
    • Xiangyang Cheng
  • View Affiliations

  • Published online on: July 28, 2021     https://doi.org/10.3892/etm.2021.10511
  • Article Number: 1077
  • Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Autophagy and apoptosis are key factors in myocardial ischemia/reperfusion (I/R) injury. MicroRNAs (miRNAs or miRs) participate in occurrence and development of myocardial I/R injury by regulating autophagy and apoptosis. The purpose of the present study was to investigate the role of miR‑590‑3p in the regulation of autophagy and apoptosis in hypoxia/reoxygenation (H/R)‑treated cardiomyocytes. Following 6 h hypoxia and 6 h reoxygenation in primary rat cardiomyocytes, miR‑590‑3p was downregulated. Transfection of miR‑590‑3p mimic inhibited the increased autophagy and apoptosis following H/R treatment. Subsequent experiments demonstrated that miR‑590‑3p regulated induction of autophagy and apoptosis by targeting hypoxia inducible factor (HIF)‑1α. Forced expression of HIF‑1α rescued the protective effect of miR‑590‑3p on H/R‑induced cardiomyocytes. In summary, the present study showed that miR‑590‑3p exhibited a protective effect on H/R‑induced cardiomyocyte injury and may be a novel target for the treatment of myocardial ischemia disease.
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October-2021
Volume 22 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gong N, Yang X, Li X, Jiang Y, Gu C, Ma S, Gao Q and Cheng X: MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α. Exp Ther Med 22: 1077, 2021.
APA
Gong, N., Yang, X., Li, X., Jiang, Y., Gu, C., Ma, S. ... Cheng, X. (2021). MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α. Experimental and Therapeutic Medicine, 22, 1077. https://doi.org/10.3892/etm.2021.10511
MLA
Gong, N., Yang, X., Li, X., Jiang, Y., Gu, C., Ma, S., Gao, Q., Cheng, X."MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α". Experimental and Therapeutic Medicine 22.4 (2021): 1077.
Chicago
Gong, N., Yang, X., Li, X., Jiang, Y., Gu, C., Ma, S., Gao, Q., Cheng, X."MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1077. https://doi.org/10.3892/etm.2021.10511