Neuroendocrine neoplasia and bone (Review)
- Authors:
- Adina Ghemigian
- Mara Carsote
- Florica Sandru
- Razvan-Cosmin Petca
- Ana-Maria Oproiu
- Aida Petca
- Ana Valea
-
Affiliations: Department of Endocrinology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Dermatology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Urology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Plastic and Reconstructive Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Endocrinology, ‘I. Hatieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania - Published online on: August 26, 2021 https://doi.org/10.3892/etm.2021.10653
- Article Number: 1219
This article is mentioned in:
Abstract
Oberndorfer S: Karzinoide tumoren des dünndarms. In: Frankfurter Zeitschrift für Pathologie, pp426-429, 1907. | |
Gill AJ: Why did they change that? Practical implications of the evolving classification of neuroendocrine tumours of the gastrointestinal tract. Histopathology. 78:162–170. 2021.PubMed/NCBI View Article : Google Scholar | |
Guadagno E, D'Avella E, Cappabianca P, Colao A and Del Basso De Caro M: Ki67 in endocrine neoplasms: To count or not to count, this is the question! A systematic review from the English language literature. J Endocrinol Invest. 43:1429–1445. 2020.PubMed/NCBI View Article : Google Scholar | |
Assarzadegan N and Montgomery E: What is new in the 2019 World Health Organization (WHO) classification of tumors of the digestive system: Review of selected updates on neuroendocrine neoplasms, appendiceal tumors, and molecular testing. Arch Pathol Lab Med. 145:664–677. 2021.PubMed/NCBI View Article : Google Scholar | |
Zappalà G, McDonald PG and Cole SW: Tumor dormancy and the neuroendocrine system: An undisclosed connection? Cancer Metastasis Rev. 32:189–200. 2013.PubMed/NCBI View Article : Google Scholar | |
Ramírez-Rentería C, Ferreira-Hermosillo A, Marrero-Rodríguez D, Taniguchi-Ponciano K, Melgar-Manzanilla V and Mercado M: An update on gastroenteropancreatic neuroendocrine neoplasms: From mysteries to paradigm shifts. Arch Med Res. 51:765–776. 2020.PubMed/NCBI View Article : Google Scholar | |
Klöppel G and La Rosa S: Ki67 labeling index: Assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms. Virchows Arch. 472:341–349. 2018.PubMed/NCBI View Article : Google Scholar | |
Kim JY, Hong SM and Ro JY: Recent updates on grading and classification of neuroendocrine tumors. Ann Diagn Pathol. 29:11–16. 2017.PubMed/NCBI View Article : Google Scholar | |
Chauhan A, Yu Q, Ray N, Farooqui Z, Huang B, Durbin EB, Tucker T, Evers M, Arnold S and Anthony LB: Global burden of neuroendocrine tumors and changing incidence in Kentucky. Oncotarget. 9:19245–19254. 2018.PubMed/NCBI View Article : Google Scholar | |
Sackstein PE, O'Neil DS, Neugut AI, Chabot J and Fojo T: Epidemiologic trends in neuroendocrine tumors: An examination of incidence rates and survival of specific patient subgroups over the past 20 years. Semin Oncol. 45:249–258. 2018.PubMed/NCBI View Article : Google Scholar | |
Riihimäki M, Hemminki A, Sundquist K, Sundquist J and Hemminki K: The epidemiology of metastases in neuroendocrine tumors. Int J Cancer. 139:2679–2686. 2016.PubMed/NCBI View Article : Google Scholar | |
Akimoto J, Fukuhara H, Suda T, Nagai K, Ichikawa M, Fukami S, Kohno M, Matsubayashi J and Nagao T: Clinicopathological analysis in patients with neuroendocrine tumors that metastasized to the brain. BMC Cancer. 16(36)2016.PubMed/NCBI View Article : Google Scholar | |
Cives M, Quaresmini D, Rizzo FM, Felici C, D'Oronzo S, Simone V and Silvestris F: Osteotropism of neuroendocrine tumors: Role of the CXCL12/ CXCR4 pathway in promoting EMT in vitro. Oncotarget. 8:22534–22549. 2017.PubMed/NCBI View Article : Google Scholar | |
Cives M, Pellè E, Rinzivillo M, Prosperi D, Tucci M, Silvestris F and Panzuto F: Bone metastases in neuroendocrine tumors: Molecular parhogenesis and implications in clinical practice. Neuroendocrinology. 111:207–216. 2021.PubMed/NCBI View Article : Google Scholar | |
Harvey NC, McCloskey EV, Mitchell PJ, Dawson-Hughes B, Pierroz DD, Reginster JY, Rizzoli R, Cooper C and Kanis JA: Mind the (treatment) gap: A global perspective on current and future strategies for prevention of fragility fractures. Osteoporos Int. 28:1507–1529. 2017.PubMed/NCBI View Article : Google Scholar | |
Liu J, Curtis EM, Cooper C and Harvey NC: State of the art in osteoporosis risk assessment and treatment. J Endocrinol Invest. 42:1149–1164. 2019.PubMed/NCBI View Article : Google Scholar | |
Kanis JA, Svedbom A, Harvey N and McCloskey EV: The osteoporosis treatment gap. J Bone Miner Res. 29:1926–1928. 2014.PubMed/NCBI View Article : Google Scholar | |
International Osteoporosis Foundation: https://www.osteoporosis.foundation/. Accessed April 1, 2021. | |
Clynes MA, Harvey NC, Curtis EM, Fuggle NR, Dennison EM and Cooper C: The epidemiology of osteoporosis. Br Med Bull. 133:105–117. 2020.PubMed/NCBI View Article : Google Scholar | |
Curtis EM, Woolford S, Holmes C, Cooper C and Harvey NC: General and specific considerations as to why osteoporosis-related care is often suboptimal. Curr Osteoporos Rep. 18:38–46. 2020.PubMed/NCBI View Article : Google Scholar | |
Barton DW, Behrend CJ and Carmouche JJ: Rates of osteoporosis screening and treatment following vertebral fracture. Spine J. 19:411–417. 2019.PubMed/NCBI View Article : Google Scholar | |
Söreskog E, Borgström F, Shepstone L, Clarke S, Cooper C, Harvey I, Harvey NC, Howe A, Johansson H, Marshall T, et al: Long-term cost-effectiveness of screening for fracture risk in a UK primary care setting: the SCOOP study. Osteoporos Int. 31:1499–1506. 2020.PubMed/NCBI View Article : Google Scholar | |
Zamborsky R, Svec A, Kokavec M and Galbavy S: Bone metastases in neuroendocrine tumors. Bratisl Lek Listy. 118:529–534. 2017.PubMed/NCBI View Article : Google Scholar | |
Koizumi M, Gokita T and Toda K: Impending atypical femoral fracture in patients with medullary thyroid cancer with skeletal metastasis treated with long-term bisphosphonate and denosumab. Clin Nucl Med. 42:463–464. 2017.PubMed/NCBI View Article : Google Scholar | |
Carsote M, Valea A, Dumitru N, Terzea D, Petrova E, Albu S, Buruiana A and Ghemigian A: Metastases in daily endocrine practice. Arch Balk Med Union. 51:476–480. 2016. | |
Rizzo FM, Vesely C, Childs A, Marafioti T, Khan MS, Mandair D, Cives M, Ensell L, Lowe H, Akarca AU, et al: Circulating tumour cells and their association with bone metastases in patients with neuroendocrine tumours. Br J Cancer. 120:294–300. 2019.PubMed/NCBI View Article : Google Scholar | |
Zheng Z, Chen C, Jiang L, Zhou X, Dai X, Song Y and Li Y: Incidence and risk factors of gastrointestinal neuroendocrine neoplasm metastasis in liver, lung, bone, and brain: A population-based study. Cancer Med. 8:7288–7298. 2019.PubMed/NCBI View Article : Google Scholar | |
Van Loon K, Zhang L, Keiser J, Carrasco C, Glass K, Ramirez MT, Bobiak S, Nakakura EK, Venook AP, Shah MH and Bergsland EK: Bone metastases and skeletal-related events from neuroendocrine tumors. Endocr Connect. 4:9–17. 2015.PubMed/NCBI View Article : Google Scholar | |
Hori T, Yasuda T, Suzuki K, Kanamori M and Kimura T: Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature. Oncol Lett. 3:1105–1108. 2012.PubMed/NCBI View Article : Google Scholar | |
Trikalinos NA, Tan BR, Amin M, Liu J, Govindan R and Morgensztern D: Effect of metastatic site on survival in patients with neuroendocrine neoplasms (NENs). An analysis of SEER data from 2010 to 2014. BMC Endocr Disord. 20(44)2020.PubMed/NCBI View Article : Google Scholar | |
Wang S and Zhang J, Liu S and Zhang J: The prognostic analysis of different metastatic patterns in pancreatic neuroendocrine tumors patients: A population based analysis. Medicine (Baltimore). 98(e17773)2019.PubMed/NCBI View Article : Google Scholar | |
Deleval N, Pesque L, Dieudonné A, Viry F, Hentic O, Lebtahi R, Ruszniewski P and de Mestier L: Prognostic impact of bone metastases detected by 18F-DOPA PET in patients with metastatic midgut neuroendocrine tumors. Eur Radiol. 31:4166–4174. 2021.PubMed/NCBI View Article : Google Scholar | |
Altieri B, Di Dato C, Modica R, Bottiglieri F, Di Sarno A, Pittaway JFH, Martini C, Faggiano A and Colao A: Bone metabolism and vitamin D implication in gastroenteropancreatic neuroendocrine tumors. Nutrients. 12(1021)2020.PubMed/NCBI View Article : Google Scholar | |
Sen Gupta P, Grozinsky-Glasberg S, Drake WM, Akker SA, Perry L, Grossman AB and Druce MR: Are serotonin metabolite levels related to bone mineral density in patients with neuroendocrine tumours? Clin Endocrinol (Oxf). 80:246–252. 2014.PubMed/NCBI View Article : Google Scholar | |
Jacobson A and Cunningham JL: Connective tissue growth factor in tumor pathogenesis. Fibrogenesis Tissue Repair. 5 (Suppl 1)(S8)2012.PubMed/NCBI View Article : Google Scholar | |
Migut AE, Kaur H and Avritscher R: Neuroendocrine tumors: Imaging of treatment and follow-up. Radiol Clin North Am. 58:1161–1171. 2020.PubMed/NCBI View Article : Google Scholar | |
Galgano SJ, Sharbidre K and Morgan DE: Multimodality imaging of neuroendocrine tumors. Radiol Clin North Am. 58:1147–1159. 2020.PubMed/NCBI View Article : Google Scholar | |
Albu SE, Geleriu A, Carsote M, Mihai A, Vasiliu C and Poiana C: The vitamin D status in menopausal women. Arch Balk MedUnion. 50:275–277. 2015. | |
Khashayar P, Meybodi HA, Amoabediny G and Larijani B: Biochemical markers of bone turnover and their role in osteoporosis diagnosis: A narrative review. Recent Pat Endocr Metab Immune Drug Discov. 9:79–89. 2015.PubMed/NCBI View Article : Google Scholar | |
Centre for Metabolic Bone Diseases, University of Sheffield, UK: FRAX® Fracture Risk Assessment Tool: https://www.sheffield.ac.uk/FRAX/tool.aspx?country=9. Accessed April 1, 2021. | |
Carsote M, Radu O, Dumitrascu A, Terzea D, Valea A and Ghemigian A: Bone and menopause: Threshold of intervention. Rom Med J. 63:233–236. 2016. | |
Sandru F, Carsote M, Albu SE, Valea A, Petca A and Dumitrascu MC: Glucagonoma: From skin lesions to the neuroendocrine component (Review). Exp Ther Med. 20:3389–3393. 2020.PubMed/NCBI View Article : Google Scholar | |
Byun J, Kim SH, Jeong HS, Rhee Y, Lee WJ and Kang CM: ACTH-producing neuroendocrine tumor of the pancreas: A case report and literature review. Ann Hepatobiliary Pancreat Surg. 21:61–65. 2017.PubMed/NCBI View Article : Google Scholar | |
Sandru F, Carsote M, Dumitrascu MC, Albu SE and Valea A: Glucocorticoids and trabecular bone score. J Med Life. 13:449–453. 2020.PubMed/NCBI View Article : Google Scholar | |
Kannivelu A, Loke KS, Kok TY, Osmany SY, Ali SZ, Suat-Jin L and Ng DC: The role of PET/CT in the evaluation of skeletal metastases. Semin Musculoskelet Radiol. 18:149–165. 2014.PubMed/NCBI View Article : Google Scholar | |
Adkins J and Lu Y: Diffuse bone metastases in pancreatic neuroendocrine tumor shown on octreoscan. Clin Nucl Med. 44:257–258. 2019.PubMed/NCBI View Article : Google Scholar | |
Gauthé M, Testart Dardel N, Ruiz Santiago F, Ohnona J, Nataf V, Montravers F and Talbot JN: Vertebral metastases from neuroendocrine tumours: How to avoid false positives on 68Ga-DOTA-TOC PET using CT pattern analysis? Eur Radiol. 28:3943–3952. 2018.PubMed/NCBI View Article : Google Scholar | |
Lim KHJ, Raja H, D'Arienzo P, Barriuso J, McNamara MG, Hubner RA, Mansoor W, Valle JW and Lamarca A: Identification of areas for improvement in the management of bone metastases in patients with neuroendocrine neoplasms. Neuroendocrinology. 110:688–696. 2020.PubMed/NCBI View Article : Google Scholar | |
Altieri B, Di Dato C, Martini C, Sciammarella C, Di Sarno A, Colao A and Faggiano A: NIKE Group. Bone metastases in neuroendocrine neoplasms: From pathogenesis to clinical management. Cancers (Basel). 11(1332)2019.PubMed/NCBI View Article : Google Scholar | |
Alexandraki KI, Pizanias M, Uri I, Thomas D, Page T, Kolomodi D, Low CS, Adesanya O, Tsoli M, Gross DJ, et al: The prognosis and management of neuroendocrine neoplasms-related metastatic bone disease: Lessons from clinical practice. Endocrine. 64:690–701. 2019.PubMed/NCBI View Article : Google Scholar | |
Zhang M, Zhao P, Shi X, Zhao A, Zhang L and Zhou L: Clinicopathological features and prognosis of gastroenteropancreatic neuroendocrine neoplasms in a Chinese population: A large, retrospective single-centre study. BMC Endocr Disord. 17(39)2017.PubMed/NCBI View Article : Google Scholar | |
Helbig G, Straczyńska-Niemiec A, Szewczyk I, Nowicka E, Bierzyńska-Macyszyn G and Kyrcz-Krzemień S: Unexpected cause of anemia: Metastasis of neuroendocrine tumor to the bone marrow. Pol Arch Med Wewn. 124:635–636. 2014.PubMed/NCBI | |
Valea A, Carsote M, Ghervan C and Georgescu C: Glycemic profile in patients with acromegaly treated with somatostatin analogue. J Med Life. 8:82–86. 2015.PubMed/NCBI | |
Lamarca A, Elliott E, Barriuso J, Backen A, McNamara MG, Hubner R and Valle JW: Chemotherapy for advanced non-pancreatic well-differentiated neuroendocrine tumours of the gastrointestinal tract, a systematic review and meta-analys: A lost cause? Cancer Treat Rev. 44:26–41. 2016.PubMed/NCBI View Article : Google Scholar | |
Poiană C, Carşote M, Ardeleanu C, Terzea D, Avramescu ET, Neamţu MC and Miulescu RD: The value of the immunohistochemistry in a case of gastric neuroendocrine tumor and thyroid metastasis. Rom J Morphol Embryol. 52:187–192. 2011.PubMed/NCBI | |
Watts NB: Postmenopausal osteoporosis: A clinical review. J Womens Health (Larchmt). 27:1093–1096. 2018.PubMed/NCBI View Article : Google Scholar | |
Misiorowski W: Osteoporosis in men. Prz Menopauzalny. 16:70–73. 2017.PubMed/NCBI View Article : Google Scholar | |
Cortellini A, Bozzetti F, Palumbo P, Brocco D, Di Marino P, Tinari N, De Tursi M, Agostinelli V, Patruno L, Valdesi C, et al: Weighing the role of skeletal muscle mass and muscle density in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: A multicenter real-life study. Sci Rep. 10(1456)2020.PubMed/NCBI View Article : Google Scholar | |
Fernández-Sala X, Barceló-Vidal J, Tusquets I and Conde-Estévez D: Effectiveness and safety of a novel dexamethasone mouthwash formulation in managing stomatitis in cancer patients. Farm Hosp. 45:41–44. 2020.PubMed/NCBI View Article : Google Scholar | |
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, et al: Clinical features of neuroendocrine prostate cancer. Eur J Cancer. 121:7–18. 2019.PubMed/NCBI View Article : Google Scholar | |
Clement DS, Tesselaar ME, van Leerdam ME, Srirajaskanthan R and Ramage JK: Nutritional and vitamin status in patients with neuroendocrine neoplasms. World J Gastroenterol. 25:1171–1184. 2019.PubMed/NCBI View Article : Google Scholar | |
Kędzierska L, Madej-Michniewicz A, Marczuk N, Dołęgowska B, Starzyńska T and Błogowski W: Clinical significance of various growth factors in patients with different gastric neoplasms. Am J Transl Res. 12:118–129. 2020.PubMed/NCBI | |
Ranade R and Basu S: Metabolic bone disease in the context of metastatic neuroendocrine tumor: Differentiation from skeletal metastasis, the molecular PET-CT imaging features, and exploring the possible etiopathologies including parathyroid adenoma (MEN1) and paraneoplastic humoral hypercalcemia of malignancy due to PTHrP hypersecretion. World J Nucl Med. 16:62–67. 2017.PubMed/NCBI View Article : Google Scholar | |
Iliesiu A, Ungureanu IA, Petca A, Constantin MM, Petca RC, Sandru F, Constantin T and Dumitrascu MC: Paraganglioma presenting as a mesenteric cystic mass: A case report. Exp Ther Med. 20:2489–2492. 2020.PubMed/NCBI View Article : Google Scholar | |
Valea A, Morar A, Ghemigian A, Petrova E, Tupea C, Popescu M, Dumitru N and Carsote M: Diagnosis of neurofibromatosis type 1-related pheocromocytoma after stroke and myocardical infarction. Rom Med J. 67:420–424. 2020. | |
Aygun N and Uludag M: Pheochromocytoma and paraganglioma: From epidemiology to clinical findings. Sisli Etfal Hastan Tip Bul. 54:159–168. 2020.PubMed/NCBI View Article : Google Scholar | |
Sandru F, Dumitrascu MC, Albu SE, Carsote M and Valea A: Osteoporosis and adrenal incidentaloma: To be or not to be? Rom J Med Pract. 14:381–384. 2019. | |
Jimenez P, Tatsui C, Jessop A, Thosani S and Jimenez C: Treatment for malignant pheochromocytomas and paragangliomas: 5 Years of progress. Curr Oncol Rep. 19(83)2017.PubMed/NCBI View Article : Google Scholar | |
Ilanchezhian M, Jha A, Pacak K and Del Rivero J: Emerging treatments for advanced/metastatic pheochromocytoma and paraganglioma. Curr Treat Options Oncol. 21(85)2020.PubMed/NCBI View Article : Google Scholar | |
Rider AJ, Walsh A, Sollenberger EL, Dryden SC, DeAngelis KD, Weir AB III and Fowler BT: Orbital pheochromocytoma metastasis in 2 patients with known pheochromocytoma. Ophthalmic Plast Reconstr Surg. 35:e131–e134. 2019.PubMed/NCBI View Article : Google Scholar | |
Rahpeyma A and Khajehahmadi S: Pheochromocytoma metastasing to the jaw: Review of the literature and new case. Indian J Surg Oncol. 11:433–437. 2020.PubMed/NCBI View Article : Google Scholar | |
Fadiga L, Saraiva J, Paiva I and Carrilho F: Thoracic spine metastasis presenting 18 years after complete resection of a phaeochromocytoma. BMJ Case Rep. 12(e229621)2019.PubMed/NCBI View Article : Google Scholar | |
Jang Khan NA, Ullah S, Siddiqui HU and Karim A: Spinal cord compression by metastatic thoracic spine paraganglioma. J Ayub Med Coll Abbottabad. 28:617–619. 2016.PubMed/NCBI | |
Ayala-Ramirez M, Palmer JL, Hofmann MC, de la Cruz M, Moon BS, Waguespack SG, Habra MA and Jimenez C: Bone metastases and skeletal-related events in patients with malignant pheochromocytoma and sympathetic paraganglioma. J Clin Endocrinol Metab. 98:1492–1497. 2013.PubMed/NCBI View Article : Google Scholar | |
Huang CT, Yang WC and Lin SF: Multiple endocrine neoplasia type 2A. Kaohsiung J Med Sci. 28:341–344. 2012.PubMed/NCBI View Article : Google Scholar | |
Gravel G, Leboulleux S, Tselikas L, Fassio F, Berraf M, Berdelou A, Ba B, Hescot S, Hadoux J, Schlumberger M, et al: Prevention of serious skeletal-related events by interventional radiology techniques in patients with malignant paraganglioma and pheochromocytoma. Endocrine. 59:547–554. 2018.PubMed/NCBI View Article : Google Scholar | |
Athimulam S and Bancos I: Evaluation of bone health in patients with adrenal tumors. Curr Opin Endocrinol Diabetes Obes. 26:125–132. 2019.PubMed/NCBI View Article : Google Scholar | |
Kim BJ, Kwak MK, Kim JS, Lee SH and Koh JM: Higher sympathetic activity as a risk factor for skeletal deterioration in pheochromocytoma. Bone. 116:1–7. 2018.PubMed/NCBI View Article : Google Scholar | |
Yokomoto-Umakoshi M, Umakoshi H, Fukumoto T, Matsuda Y, Nagata H, Ogata M, Kawate H, Miyazawa T, Sakamoto R and Ogawa Y: Q-AND-A study group. Pheochromocytoma and paraganglioma: An emerging cause of secondary osteoporosis. Bone. 133(115221)2020.PubMed/NCBI View Article : Google Scholar | |
Yokomoto-Umakoshi M, Umakoshi H, Sakamoto R, Fukumoto T, Ogata M, Nakano Y, Iwahashi N, Kaneko H, Mizoguchi N, Hattori A, et al: Role of deteriorated bone quality in the development of osteoporosis in pheochromocytoma and paraganglioma. Bone. 142(115607)2021.PubMed/NCBI View Article : Google Scholar | |
Yokomoto-Umakoshi M, Umakoshi H, Ogata M, Fukumoto T, Matsuda Y, Miyazawa T, Sakamoto R and Ogawa Y: Q-AND-A study group. Coexistence of osteoporosis and atherosclerosis in pheochromocytoma: New insights into its long-term management. Osteoporos Int. 31:2151–2160. 2020.PubMed/NCBI View Article : Google Scholar | |
Poiana C, Radoi V, Carsote M and Bilezikian JP: New clues that may link osteoporosis to the circulating lipid profile. Bone Res. 1:260–266. 2013.PubMed/NCBI View Article : Google Scholar | |
Jackuliak P, Kužma M, Killinger Z and Payer J: Good long-term glycemic compensation is associated with better trabecular bone score in postmenopausal women with type 2 diabetes. Physiol Res. 68 (Suppl 2):S149–S156. 2019.PubMed/NCBI View Article : Google Scholar | |
Webb SM and Valassi E: Morbidity of Cushing's syndrome and impact of treatment. Endocrinol Metab Clin North Am. 47:299–311. 2018.PubMed/NCBI View Article : Google Scholar | |
Dumitrascu MC, Stanescu AMA, Bejan C, Sandru F, Toader DO, Radavoi DG, Cotirlet A, Judea Pusta CT and Diaconu CC: Obesity and its implications on stress urinary incontinence. Rev Chim. 70:3660–3662. 2019. | |
Young J, Haissaguerre M, Viera-Pinto O, Chabre O, Baudin E and Tabarin A: Management of endocrine disease: Cushing's syndrome due to ectopic ACTH secretion: An expert operational opinion. Eur J Endocrinol. 182:R29–R58. 2020.PubMed/NCBI View Article : Google Scholar | |
Grigoryan S, Avram AM and Turcu AF: Functional imaging in ectopic Cushing syndrome. Curr Opin Endocrinol Diabetes Obes. 27:146–154. 2020.PubMed/NCBI View Article : Google Scholar | |
Kyriacou A, Stepien KM and Issa B: Urinary steroid metabolites in a case of florid ectopic Cushing's syndrome and clinical correlations. Hormones (Athens). 15:540–547. 2016.PubMed/NCBI View Article : Google Scholar | |
Hayes AR and Grossman AB: The ectopic adrenocorticotropic hormone syndrome: Rarely easy, always challenging. Endocrinol Metab Clin North Am. 47:409–425. 2018.PubMed/NCBI View Article : Google Scholar | |
Șandru F, Dumitrașcu MC, Albu SE, Carsote M and Valea A: Obesity and osteoporotic fractures. Rom J Mil Med. 123:166–171. 2020. | |
Carsote M, Preda SA, Mitroi M, Camen A and Radu L: Serum osteocalcin, P1NP, alkaline phosphase, and crosslaps in humans: The relationship with body mass index. Rev Chim. 70:1615–1618. 2019. | |
Broersen LHA, van Haalen FM, Kienitz T, Biermasz NR, Strasburger CJ, Dekkers OM and Pereira AM: Sex Differences in presentation but not in outcome for ACTH-dependent Cushing's syndrome. Front Endocrinol (Lausanne). 10(580)2019. | |
Vinolas H, Grouthier V, Mehsen-Cetre N, Boisson A, Winzenrieth R, Schaeverbeke T, Mesguich C, Bordenave L and Tabarin A: Assessment of vertebral microarchitecture in overt and mild Cushing's syndrome using trabecular bone score. Clin Endocrinol (Oxf). 89:148–154. 2018.PubMed/NCBI View Article : Google Scholar | |
Valassi E, Santos A, Yaneva M, Tóth M, Strasburger CJ, Chanson P, Wass JA, Chabre O, Pfeifer M, Feelders RA, et al: The European registry on Cushing's syndrome: 2-Year experience. Baseline demographic and clinical characteristics. Eur J Endocrinol. 165:383–392. 2011.PubMed/NCBI View Article : Google Scholar | |
Rashid F, Riccio SA, Munk PL, Malfair D and Heran MK: Vertebroplasty for vertebral compression fractures secondary to Cushing's syndrome induced by an ACTH-producing bronchial carcinoid tumour. Singapore Med J. 50:e147–e150. 2009.PubMed/NCBI | |
Coe SG, Tan WW and Fox TP: Cushing's syndrome due to ectopic adrenocorticotropic hormone production secondary to hepatic carcinoid: Diagnosis, treatment, and improved quality of life. J Gen Intern Med. 23:875–878. 2008.PubMed/NCBI View Article : Google Scholar | |
Neary NM, Lopez-Chavez A, Abel BS, Boyce AM, Schaub N, Kwong K, Stratakis CA, Moran CA, Giaccone G and Nieman LK: Neuroendocrine ACTH-producing tumor of the thymus-experience with 12 patients over 25 years. J Clin Endocrinol Metab. 97:2223–2230. 2012.PubMed/NCBI View Article : Google Scholar | |
Gut P: Liver metastases in gastroenteropancreatic neuroendocrine tumours-treatment methods. Prz Gastroenterol. 15:207–214. 2020.PubMed/NCBI View Article : Google Scholar | |
Carsote M, Petrova EN, Radu O, Goldstein A, Ghemigian A and Valea A: Serotonin: Beyond menopause: Rom J Med Pract (Pract Med). 11:270–272. 2016. | |
Szajer J, Yung G, Russo R and Mansberg R: Adrenocorticotropic hormone-secreting neuroendocrine tumor of the rectum demonstrated on 68Ga-DOTATATE and 18F-FDG PET imaging. Clin Nucl Med. 42:773–775. 2017.PubMed/NCBI View Article : Google Scholar | |
Angarita FA, Rodríguez JL, Meek E, Sánchez JO, Tawil M and Torregrosa L: Locally-advanced primary neuroendocrine carcinoma of the breast: Case report and review of the literature. World J Surg Oncol. 11(128)2013.PubMed/NCBI View Article : Google Scholar | |
Banerjee SS and Eyden B: Divergent differentiation in malignant melanomas: A review. Histopathology. 52:119–129. 2008.PubMed/NCBI View Article : Google Scholar | |
Poiană C, Neamţu MC, Avramescu ET, Carşote M, Trifănescu R, Terzea D, Neamţu OM and Dănciulescu Miulescu R: The dedifferentiation of neuroendocrine tumor metastases: Myth or reality? Rom J Morphol Embryol. 54:201–203. 2013.PubMed/NCBI | |
Dumas M, Laly P, Gottlieb J, Vercellino L, Paycha F, Bagot M, Baroudjian B, Madelaine I, Basset-Seguin N, Eftekhari P, et al: Osteopenia and fractures associated with long-term therapy with MEK inhibitors. Melanoma Res. 28:641–644. 2018.PubMed/NCBI View Article : Google Scholar | |
Lee YK, Lee EG, Kim HY, Lee Y, Lee SM, Suh DC, Yoo JI and Lee S: Osteoporotic fractures of the spine, hip, and other locations after adjuvant endocrine therapy with aromatase inhibitors in breast cancer patients: A meta-analysis. J Korean Med Sci. 35(e403)2020.PubMed/NCBI View Article : Google Scholar | |
Li Y and Simonds WF: Endocrine neoplasms in familial syndromes of hyperparathyroidism. Endocr Relat Cancer. 23:R229–R247. 2016.PubMed/NCBI View Article : Google Scholar | |
Miulescu R, Balaban DV, Sandru F and Jinga M: Cutaneous manifestations in pancreatic diseases-A review. J Clin Med. 9(2611)2020.PubMed/NCBI View Article : Google Scholar | |
Slouma M, Abbes M, Dhahri R, Litaiem N, Gueddiche N, Mansouri N, Msekni I, Gharsallah I, Metoui L and Louzir B: Multiple endocrine neoplasia type 1 revealed by a hip pathologic fracture. Clin Rheumatol. 40:775–782. 2021.PubMed/NCBI View Article : Google Scholar | |
Herath M, Parameswaran V, Thompson M, Williams M and Burgess J: Paediatric and young adult manifestations and outcomes of multiple endocrine neoplasia type 1. Clin Endocrinol (Oxf). 91:633–638. 2019.PubMed/NCBI View Article : Google Scholar | |
Mele C, Mencarelli M, Caputo M, Mai S, Pagano L, Aimaretti G, Scacchi M, Falchetti A and Marzullo P: Phenotypes associated with MEN1 syndrome: A focus on genotype-phenotype correlations. Front Endocrinol (Lausanne). 11(591501)2020.PubMed/NCBI View Article : Google Scholar | |
Sandru F, Carsote M, Valea A, Albu SE, Petca RC and Dumitrascu MC: Somatostatinoma: Beyond neurofibromatosis type 1 (review). Exp Ther Med. 20:3383–3388. 2020.PubMed/NCBI View Article : Google Scholar | |
Shah S and George KJ: The association of spinal deformity with dural ectasia in neurofibromatosis type 1. Br J Neurosurgery. 33:620–623. 2019.PubMed/NCBI View Article : Google Scholar | |
Prudhomme L, Delleci C, Trimouille A, Chateil JF, Prodhomme O, Goizet C and Van Gils J: Severe thoracic and spinal bone abnormalities in neurofibromatosis type 1. Eur J Med Genet. 63(103815)2020.PubMed/NCBI View Article : Google Scholar | |
Eads JR, Reidy-Lagunes D, Soares HP, Chan JA, Anthony LB, Halfdanarson TR, Naraev BG, Wolin EM, Halperin DM, Li D, et al: Differential diagnosis of diarrhea in patients with neuroendocrine tumors. Pancreas. 49:1123–1130. 2020.PubMed/NCBI View Article : Google Scholar | |
Michalowska M, Znorko B, Kaminski T, Oksztulska-Kolanek E and Pawlak D: New insights into tryptophan and its metabolites in the regulation of bone metabolism. J Physiol Pharmacol. 66:779–791. 2015.PubMed/NCBI | |
Al Saedi A, Sharma S, Summers MA, Nurgali K and Duque G: The multiple faces of tryptophan in bone biology. Exp Gerontol. 129(110778)2020.PubMed/NCBI View Article : Google Scholar | |
Khanassov V, Hu J, Reeves D and van Marwijk H: Selective serotonin reuptake inhibitor and selective serotonin and norepinephrine reuptake inhibitor use and risk of fractures in adults: A systematic review and meta-analysis. Int J Geriatr Psychiatry. 33:1688–1708. 2018.PubMed/NCBI View Article : Google Scholar | |
Banskota S, Ghia JE and Khan WI: Serotonin in the gut: Blessing or a curse. Biochimie. 161:56–64. 2019.PubMed/NCBI View Article : Google Scholar |