Ethylparaben induces subconjunctival fibrosis via the Wnt/β‑catenin signaling pathway

  • Authors:
    • Fengge Liu
    • Xiangfeng Kong
    • Hui Kong
  • View Affiliations

  • Published online on: January 28, 2021     https://doi.org/10.3892/etm.2021.9726
  • Article Number: 295
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Abstract

The aim of the present study was to explore the etiology of subconjunctival fibrosis (SCF) induced by ethylparaben, the most prevalent preservative in Chinese eye drops. Ethylparaben was administered to the left eyes of male Sprague‑Dawley rats in the experimental group twice daily for 1 month, whereas the control group received PBS. Experimental group rats displayed a mild promotion in density of fibroblasts and a tighter deposition of collagen in the bulbar subepithelial connective tissue compared with the control group. Furthermore, the present findings revealed that extracellular matrix expression was promoted in murine bulbar conjunctival tissues in the experimental group. In primary conjunctival fibroblasts, expression of ECM triggered by ethylparaben was suppressed by XAV‑939. Furthermore, stimulation of the Wnt/β‑catenin axis triggered by ethylparaben was impaired by XAV‑939. In conclusion, SCF triggered by ethylparaben results from extra ECM generation of conjunctival fibroblasts via the Wnt/β‑catenin axis.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu F, Kong X and Kong H: Ethylparaben induces subconjunctival fibrosis via the Wnt/β‑catenin signaling pathway. Exp Ther Med 21: 295, 2021
APA
Liu, F., Kong, X., & Kong, H. (2021). Ethylparaben induces subconjunctival fibrosis via the Wnt/β‑catenin signaling pathway. Experimental and Therapeutic Medicine, 21, 295. https://doi.org/10.3892/etm.2021.9726
MLA
Liu, F., Kong, X., Kong, H."Ethylparaben induces subconjunctival fibrosis via the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 21.4 (2021): 295.
Chicago
Liu, F., Kong, X., Kong, H."Ethylparaben induces subconjunctival fibrosis via the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 21, no. 4 (2021): 295. https://doi.org/10.3892/etm.2021.9726